The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds

Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Jimmy

￥46,145 total

includes taxes & fees

Jun 11 - Jun 12

The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Markus

￥46,668 total

includes taxes & fees

Jul 5 - Jul 6

Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Michael

￥38,532 total

includes taxes & fees

Jun 15 - Jun 16

Queen with Pool View | Minibar, in-room safe, individually decorated, individually furnished

Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Olha

￥29,081 total

includes taxes & fees

Jun 21 - Jun 22

Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Jennifer

￥37,136 total

includes taxes & fees

Jun 11 - Jun 12

Artist House Key West

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

NATHAN

￥31,972 total

includes taxes & fees

Jun 23 - Jun 24

11 Gecko's Garden - Adults Only | Premium bedding, pillowtop beds, individually decorated

Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Akhenaton

￥28,688 total

includes taxes & fees

Jun 10 - Jun 11

Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Matthew

￥24,675 total

includes taxes & fees

Jun 15 - Jun 16

The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Julian

￥64,685 total

includes taxes & fees

Jun 10 - Jun 11

The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Lucy

￥38,486 total

includes taxes & fees

Jun 10 - Jun 11

Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Brinkley

￥35,775 total

includes taxes & fees

Jul 1 - Jul 2

Deluxe Suite, 1 King Bed, Private Pool | View from room

H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Elizabeth

￥70,090 total

includes taxes & fees

Jun 21 - Jun 22

L'Habitation Guest House

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Amy

￥24,163 total

includes taxes & fees

Jun 15 - Jun 16

Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

gerald

￥34,091 total

includes taxes & fees

Jun 11 - Jun 12

Cigar House King Suite w/ Poolside porch | Balcony view

Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Troy

￥30,879 total

includes taxes & fees

Jun 14 - Jun 15

Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Robert

￥43,064 total

includes taxes & fees

Jun 29 - Jun 30

Caribbean House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

Jeff

￥23,069 total

includes taxes & fees

Jun 15 - Jun 16

Outdoor pool, open 8:00 AM to 10:00 PM, sun loungers

Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Nanci

￥33,214 total

includes taxes & fees

Jun 10 - Jun 11

Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

BOBBY J.

￥54,719 total

includes taxes & fees

Jun 22 - Jun 23

3 outdoor pools, a heated pool, sun loungers

Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Lori

￥32,198 total

includes taxes & fees

Jun 14 - Jun 15

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Star rating	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,011 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,008 reviews	View
The Gardens Hotel	4.0 star property	9.8 Exceptional 1,006 reviews	View
Simonton Court Historic Inn & Cottages	2.5 star property	9.8 Exceptional 977 reviews	View
Key West Villas	3.5 star property	9.8 Exceptional 262 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Wicker Guesthouse

4/10 Poor

"I had a room that was back down an outdoor walkway that flooded with about 8 in a of water and there was no other way to the room.I made note with the office and they were not very responsive. I feel the room was a fire has hard because you only had the one way out. Multiply plug in strips in the room with various things plugged in. I was a single traveler, as a single person, don’t let them put you in 208 and forget about you."

La Concha Key West, Autograph Collection

6/10 Okay

"The hotel is in a great location. There were a few issues: I booked a king room But they gave us 2 queen beds plus the internet never worked so no streaming Netflix, prime or tv. They sent engineers to our room several times but never got it to work. I wish there was a hot tub but there isn’t and there are no ice machines, you have to ask front desk for ice whenever needed."

Heron House - Adult Only

8/10 Good

"The property was gorgeous and peaceful. It was close to all of the action, but totally quiet once you turned the corner into Heron House. Breakfast was personally just like I eat at home, so I was happy with everything provided. My room was unbelievable. It was gorgeous and spacious. There was plenty of space for belongings. The air condition was as perfect as it comes, and the room was always nice and cool. I appreciated that there was a functioning sink placed as a kitchenette outside of the bathroom. Now, the downside: all of the plumbing except for the toilet was terrible. There were lightbulbs in the room that needed changing. The lightbulb inside the closet was burned out, but needed to find things. The lamp by the bed was loose from the wall, and the lampshade kept falling off. I think the owners need to do a walk-through and check out these things. That said and done, I would return to Heron House in a heartbeat."

Pegasus International Hotel

10/10 Excellent

"Very clean, nice breakfast, clean pool, quiet outdoor shaded area to chill out. Wonderful Natalia and the rest of the staff were very kind and considerate of every need. There was a guest asked to leave and fined for smoking on the property. THEY DON"T ALLOW DISRESPECTFUL CLIENTS! Stay with Natalia and you will have a great time. "

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

4.4/5 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1535 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Caribbean House is one of the top choices for your stay based on our traveler data, and this B&B offers free breakfast and private balconies. Other good choices close by include La Concha Key West, Autograph Collection and Southernmost Beach Resort and Guesthouses.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1535 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Film Society, and Red Barn Theater if you're interested in local theater.

Explore a world of travel with Expedia

Key West Vacations

Big Pine Key Vacation Rentals

Find hotels near Florida Keys National Marine Sanctuary, Key West from ￥23,069

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Florida Keys National Marine Sanctuary hotels

Almond Tree Inn Hotel - Adults Only

The Gardens Hotel

Orchid Key Inn - Adults Only

Simonton Court Historic Inn & Cottages

Key West Villas

Artist House Key West

Tropical Inn

Douglas House - Adults Only

The Marquesa Hotel

The Conch House Heritage Inn

Coco Plum Inn

H2O Suites - Adults Only

L'Habitation Guest House

Duval House

Island City House Hotel

Marrero's Guest Mansion

Caribbean House

Ella's Cottages - Key West Historic Inns

Southernmost House - Adult Exclusive

Ambrosia Key West

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Wicker Guesthouse

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

Frequently asked questions

Explore a world of travel with Expedia