The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds

Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

mario

￥44,230 total

includes taxes & fees

Jun 9 - Jun 10

Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Michael

￥45,485 total

includes taxes & fees

Jun 10 - Jun 11

The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Markus

￥43,022 total

includes taxes & fees

Jun 28 - Jun 29

Queen with Pool View | Minibar, in-room safe, individually decorated, individually furnished

Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Olha

￥26,821 total

includes taxes & fees

Jun 7 - Jun 8

The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Julian

￥64,580 total

includes taxes & fees

Jun 9 - Jun 10

The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Lucy

￥38,424 total

includes taxes & fees

Jun 9 - Jun 10

Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Matthew

￥29,304 total

includes taxes & fees

Jun 18 - Jun 19

11 Gecko's Garden - Adults Only | Premium bedding, pillowtop beds, individually decorated

Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Akhenaton

￥34,395 total

includes taxes & fees

Jun 8 - Jun 9

Deluxe Suite, 1 King Bed, Private Pool | View from room

H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Elizabeth

￥70,024 total

includes taxes & fees

Jun 8 - Jun 9

L'Habitation Guest House

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Megan

￥25,022 total

includes taxes & fees

Jun 8 - Jun 9

Cigar House King Suite w/ Poolside porch | Balcony view

Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Troy

￥31,202 total

includes taxes & fees

Jun 9 - Jun 10

Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

gerald

￥30,261 total

includes taxes & fees

Jun 8 - Jun 9

Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Robert

￥42,303 total

includes taxes & fees

Jun 8 - Jun 9

Outdoor pool, open 8:00 AM to 10:00 PM, sun loungers

Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Nanci

￥36,669 total

includes taxes & fees

Jun 29 - Jun 30

Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Jill

￥66,424 total

includes taxes & fees

Jun 21 - Jun 22

The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Kim

￥27,631 total

includes taxes & fees

Jun 10 - Jun 11

3 outdoor pools, a heated pool, sun loungers

Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Lori

￥35,221 total

includes taxes & fees

Jun 10 - Jun 11

Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

BOBBY J.

￥54,668 total

includes taxes & fees

Jun 21 - Jun 22

Paradise Inn Key West - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Paul

￥27,474 total

includes taxes & fees

Jun 15 - Jun 16

Westwinds Inn

Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary

michael

￥33,211 total

includes taxes & fees

Jun 9 - Jun 10

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Star rating	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,005 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,005 reviews	View
The Gardens Hotel	4.0 star property	9.8 Exceptional 1,001 reviews	View
Simonton Court Historic Inn & Cottages	2.5 star property	9.8 Exceptional 975 reviews	View
The Marquesa Hotel	3.5 star property	9.8 Exceptional 1,000 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

La Concha Key West, Autograph Collection

10/10 Excellent

"The staff was extraordinary! The best vacation and hospitality! And a lovely property and location. I will be back!!"

Pegasus International Hotel

10/10 Excellent

"We had a wonderful stay at this hotel in Key West. The property was clean, well-maintained, and the staff was friendly and accommodating throughout our visit. The location on Duval Street was perfect—everything was within walking distance, including restaurants, shops, attractions, and nightlife. The hotel provided a comfortable and relaxing atmosphere while still being right in the heart of all the action. We enjoyed being able to explore Key West on foot without needing a car. Overall, this was a great place to stay, and we would definitely recommend it to anyone looking for a convenient, clean, and enjoyable Key West experience."

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Our room was cozy and clean. The pool was nice and had towels and sunscreen for guests to use. The property was beautiful and so calming. The happy hour from 5:00 to 7:00 was fun and enjoyable. The free coffee and water was a great perk. The breakfast looked delicious and was well maintained. We didn't use the hot tub. It was quite warm without it but it looked very clean and fun to enjoy."

Opal Key Resort & Marina, Key West

10/10 Excellent

"Opal key was an amazing place to stay. The entire staff were friendly and helpful. My wife and I were celebrating our 31st wedding anniversary and we kinda felt a little spoiled by the amenities and service. If there was a negative we couldn’t get the room temperature down to where we like it. But that could have been due to the outside heat. Overall we thoroughly enjoyed our stay and will definitely stay again!"

Pier House Resort & Spa

10/10 Excellent

"My wife and I went down there for a four night stay and had a wonderful experience! We stayed in an ocean view room, which was absolutely beautiful. The staff was very friendly and helpful. The location could not have been better, and it is in walking distance to pretty much everything. The resort has its own private pool and beach, which was such a unique bonus. We were also very impressed by how intentional the resort is about wheelchair accessibility. My mother-in-law has ALS and is in a wheelchair, so we are already planning a trip to bringing her to this resort. We give it five stars!"

Southernmost Beach Resort and Guesthouses

6/10 Okay

"Look, we had a nice time. I put "OK" for your survey questions which may seem like we didn't enjoy. But, it would be hard to put "Good" for your survey answers. The beach was unusable due to dead, smelly seaweed that permeated the main pool, overall exterior (stairs, pool area, etc.) rooster poop, cigarette butts, etc. I particularly did not like the $65 resort fee per day. That was a surprise expense!"

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

4.4/5 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1537 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Caribbean House is one of the top choices for your stay based on our traveler data, and this B&B offers free breakfast and private balconies. Other good choices close by include La Concha Key West, Autograph Collection and Southernmost Beach Resort and Guesthouses.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1537 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Burlesque Theater, and Key West Film Society if you're interested in local theater.

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Our top choices for Florida Keys National Marine Sanctuary hotels

Almond Tree Inn Hotel - Adults Only

Orchid Key Inn - Adults Only

The Gardens Hotel

Simonton Court Historic Inn & Cottages

The Marquesa Hotel

The Conch House Heritage Inn

Douglas House - Adults Only

Tropical Inn

H2O Suites - Adults Only

L'Habitation Guest House

Island City House Hotel

Duval House

Marrero's Guest Mansion

Ella's Cottages - Key West Historic Inns

Santa Maria Suites

The Grand Guesthouse

Ambrosia Key West

Southernmost House - Adult Exclusive

Paradise Inn Key West - Adults Only

Westwinds Inn

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

La Concha Key West, Autograph Collection

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

Frequently asked questions

Explore a world of travel with Expedia