The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds

Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Jimmy

￥48,129 total

includes taxes & fees

Jun 30 - Jul 1

Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Michael

￥45,479 total

includes taxes & fees

Jun 9 - Jun 10

The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Markus

￥46,704 total

includes taxes & fees

Jun 21 - Jun 22

Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Matthew

￥24,695 total

includes taxes & fees

Jun 15 - Jun 16

Queen with Pool View | Minibar, in-room safe, individually decorated, individually furnished

Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Olha

￥29,104 total

includes taxes & fees

Jun 15 - Jun 16

The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Julian

￥64,738 total

includes taxes & fees

Jun 9 - Jun 10

11 Gecko's Garden - Adults Only | Premium bedding, pillowtop beds, individually decorated

Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Akhenaton

￥28,711 total

includes taxes & fees

Jun 9 - Jun 10

The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Lucy

￥38,518 total

includes taxes & fees

Jun 9 - Jun 10

Premium bedding, iron/ironing board, free WiFi, bed sheets

Weatherstation Inn

Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary

A. Elise

￥34,082 total

includes taxes & fees

Jun 10 - Jun 11

Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Brinkley

￥33,333 total

includes taxes & fees

Jun 10 - Jun 11

Deluxe Suite, 1 King Bed, Private Pool | View from room

H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Elizabeth

￥70,148 total

includes taxes & fees

Jun 9 - Jun 10

L'Habitation Guest House

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Amy

￥23,262 total

includes taxes & fees

Jun 9 - Jun 10

Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Robert

￥43,098 total

includes taxes & fees

Jun 9 - Jun 10

Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

gerald

￥29,088 total

includes taxes & fees

Jun 14 - Jun 15

Cigar House King Suite w/ Poolside porch | Balcony view

Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Troy

￥30,904 total

includes taxes & fees

Jun 14 - Jun 15

Outdoor pool, open 8:00 AM to 10:00 PM, sun loungers

Ella's Cottages - Key West Historic Inns

Old Town Key West, 0.9 km from Florida Keys National Marine Sanctuary

Nanci

￥37,565 total

includes taxes & fees

Jun 10 - Jun 11

Caribbean House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

Jeff

￥24,688 total

includes taxes & fees

Jun 10 - Jun 11

Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Jill

￥66,541 total

includes taxes & fees

Jun 21 - Jun 22

Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

BOBBY J.

￥54,765 total

includes taxes & fees

Jun 21 - Jun 22

3 outdoor pools, a heated pool, sun loungers

Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Lori

￥35,306 total

includes taxes & fees

Jun 14 - Jun 15

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Star rating	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,010 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,007 reviews	View
The Gardens Hotel	4.0 star property	9.8 Exceptional 1,003 reviews	View
Douglas House - Adults Only	3.0 star property	9.6 Exceptional 412 reviews	View
Simonton Court Historic Inn & Cottages	2.5 star property	9.8 Exceptional 976 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Heron House - Adult Only

10/10 Excellent

"Perfect location. Perfect hosts. Perfect room. Have recommended this place to everyone we know! Thank you !"

Opal Key Resort & Marina, Key West

10/10 Excellent

"⭐⭐⭐⭐⭐ This is, without a doubt, my favorite hotel. I stay here every time I visit because the service is always outstanding. The staff is friendly and welcoming, the rooms are spotless, the facilities are well maintained, and the location is perfect. They consistently make me feel at home, which is why I keep coming back. Highly recommended in every way! ❤️🤗✨"

La Concha Key West, Autograph Collection

10/10 Excellent

"Not overstating this, it was the most exquisite and splendid hotel experience of my life. The staff, room, amenities were superb and I cannot wait to return to La Concha on my next visit. Thank you to Jennifer, in guest relations for making this a truly memorable experience."

Douglas House - Adults Only

10/10 Excellent

"We booked for convenience of location as a first time visit to Key West and it did not disappoint. This location puts you within walking distance of a multitude of shops, restaraunts and noted landmarks. Staff was very kind and attentive, and small but safe and clean pool area was excellent for relaxation."

Pegasus International Hotel

10/10 Excellent

"We had a wonderful stay at this hotel in Key West. The property was clean, well-maintained, and the staff was friendly and accommodating throughout our visit. The location on Duval Street was perfect—everything was within walking distance, including restaurants, shops, attractions, and nightlife. The hotel provided a comfortable and relaxing atmosphere while still being right in the heart of all the action. We enjoyed being able to explore Key West on foot without needing a car. Overall, this was a great place to stay, and we would definitely recommend it to anyone looking for a convenient, clean, and enjoyable Key West experience."

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

4.4/5 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1537 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Caribbean House is one of the top choices for your stay based on our traveler data, and this B&B offers free breakfast and private balconies. Other good choices close by include La Concha Key West, Autograph Collection and Southernmost Beach Resort and Guesthouses.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1537 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Burlesque Theater, and Key West Film Society if you're interested in local theater.

Explore a world of travel with Expedia

Key West Vacations

Big Pine Key Vacation Rentals

Find hotels near Florida Keys National Marine Sanctuary, Key West from ￥23,262

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Florida Keys National Marine Sanctuary hotels

Almond Tree Inn Hotel - Adults Only

Orchid Key Inn - Adults Only

The Gardens Hotel

Douglas House - Adults Only

Simonton Court Historic Inn & Cottages

The Marquesa Hotel

Tropical Inn

The Conch House Heritage Inn

Weatherstation Inn

Coco Plum Inn

H2O Suites - Adults Only

L'Habitation Guest House

Marrero's Guest Mansion

Duval House

Island City House Hotel

Ella's Cottages - Key West Historic Inns

Caribbean House

Santa Maria Suites

Southernmost House - Adult Exclusive

Ambrosia Key West

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Heron House - Adult Only

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

Frequently asked questions

Explore a world of travel with Expedia