Eastern Panama Vacations

Book a Hotel + Flight or Car together to unlock savings

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  • Plan, book, travel with confidence

  • Better together

    Save up to ￥109,000 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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Find the Best Eastern Panama Vacation Packages

Eastern Panama Hotel Deals

Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
The price is ￥73,840 per night from Jul 26 to Jul 27
￥73,840
￥81,261 total
Jul 26 - Jul 27
includes taxes & fees
10/10 Exceptional! (12 reviews)
"This resort is one of those special places you find that redefines a vacation. It is about a 15 minute boat ride from the dock, occupying the back side of Isla Grande and looking out to the Caribbean Sea. We were there during low season in July, and were fortunate enough to be one of just a few visitors ..."

Reviewed on Jul 8, 2026

Ordovician Beach Resort
san blas luxury tour

san blas luxury tour

2 out of 5
guna yala Nusatupo Guna Yala
The price is ￥22,919 per night from Jul 16 to Jul 17
￥22,919
￥25,696 total
Jul 16 - Jul 17
includes taxes & fees
san blas luxury tour
HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
The price is ￥16,007 per night from Jul 14 to Jul 15
￥16,007
￥17,608 total
Jul 14 - Jul 15
includes taxes & fees
HOTEL ISLA GRANDE
See all 194 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Eastern Panama attractions

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.
See properties

Frequently asked questions

How much does an Eastern Panama vacation package cost?
The most affordable Eastern Panama vacation package is , so your dream getaway can become a reality — without breaking the bank. Bundle flights, hotels and car rentals to tailor make a package that matches your traveling style.
How do I get a cheap travel package to Eastern Panama?
Lock in flights that suit your schedule, add a hotel to your booking and watch the savings pile up with an Eastern Panama vacation package. It's as simple as that! From flights and hotels to rental cars and activities, Expedia is where your cheap getaway begins. And with over 550 air carriers and 1,000,000 hotels around the world to choose from, you won't be short of choice.
What are the top hotels in Eastern Panama?
For hotels in San Blas Islands with friendly service and cozy beds, look up Private Over The Water Cabin On San Blas Island and San Blas Private Over - The - Water Cabin. If you plan to explore Narganá as well, you can look forward to a great night's sleep at Paradise Over The Water Cabins In San Blas or San Blas Private Over - The - Water Cabin.
How far in advance should I book my Eastern Panama vacation?
Smart travelers often reserve their seats as early as possible. You can generally look up international fares on Expedia up to 12 months before your intended flight. If you're booking last minute, don't despair. Low prices sometimes occur just weeks prior to departure.
What does an Expedia Eastern Panama travel package include?
Flights, rental cars and hotels, or any combination of the three — it's your choice. Whether you're visiting Eastern Panama with the kids or traveling by yourself, there's a package to fit every style and budget. Once you've made your booking, why not add on a couple of tours or activities?
What should I know before booking an Eastern Panama travel package?
Booking all the parts of your getaway together is an excellent way to save. Combine your car rentals, flights and hotels into a neat little package. But it's not just hotels. Expedia features all types of properties, including vacation rentals like mountain cabins and city apartments. Your choices are almost endless!
Can I choose my airline with an Eastern Panama Expedia vacation package?
Yes — that's the beauty of an Expedia vacation package. You're in charge! We have access to more than 550 airline partners across the globe, so you have loads of choice when planning your Eastern Panama getaway.
If I'm not able to travel, can I cancel my Eastern Panama vacation package?
You can. We realize life doesn't always go to plan, so we're happy to help if you have to make changes to your Eastern Panama vacation package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may charge you a fee if your booking was made more than 24 hours ago. Look up our Customer Service Portal for more information. Also, check your itinerary for the finer details on change fees.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.