Des Moines Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Our top choices for Des Moines vacation rentals

10.0 out of 10, Exceptional, (2)
"Cozy, had everything we needed, convenient "
United States
Jordan S.
The price is ¥12,505
¥34,815 total
includes taxes & fees
Dec 29 - Dec 30
Cozy Cottage Near Downtown Walkable to Dining and Boutique Shopping

Apartment in Downtown Des Moines

Spacious Studio Unit in Des Moines
9.0 out of 10, Wonderful, (2)
"We really enjoyed our stay at this cute little Studio in Des Moines. The location is great - right next to the Capital and Interstate. Will be back again soon :)"
United States
Amber V.
The price is ¥7,797
¥21,000 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Spacious Studio Unit in Des Moines
10.0 out of 10, Exceptional, (2)
"The place was located right next door to Drake which made doing a campus visit easily walkable and so were restaurants. Found parking on the street nearby and didn’t have to move the car until checkout. "
United States
Thomas
The price is ¥8,280
¥27,613 total
includes taxes & fees
Dec 28 - Dec 29
Sleepover: Impressive Studio and Gym - Des Moines

Apartment in Downtown Des Moines

Cozy 2B1B w/ Coffee, Wi-Fi & Free Parking
9.0 out of 10, Wonderful, (11)
"Great location. Second stay in 2025. Hosts are kind and gracious. Clean unit as described, quiet neighborhood and great downtown location. "
United States
William C.
The price is ¥11,912
¥30,827 total
includes taxes & fees
Dec 28 - Dec 29
Cozy 2B1B w/ Coffee, Wi-Fi & Free Parking
10.0 out of 10, Exceptional, (2)
"Clean and quiet for our stay. "
United States
Jackie
The price is ¥9,684
¥29,186 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Sleepover: Attractive Studio and Gym - Des Moines

Apartment in Downtown Des Moines

Quiet Studio on Grand Near Hospitals!
8.6 out of 10, Excellent, (10)
"Pretty nice spot"
United States
Alberto P.
The price is ¥7,033
¥148,210 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Quiet Studio on Grand Near Hospitals!
2.0 star property
10.0 out of 10, Exceptional, (1)
"Awesome !!"
United States
Heather
The price is ¥7,797
¥21,850 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Chic Des Moines 1BR with Amenities & Prime Location
2.0 star property
9.8 out of 10, Exceptional, (8)
"Was a great place to stay with my girlfriends for a concert at the Casey's center - very walkable & close to many bars and food places. Liked the games in community room in the basement! Would definitely stay again. "
United States
Angela
The price is ¥11,384
¥28,545 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Skyline Serenity 2BR/2BA with Stunning City Views
10.0 out of 10, Exceptional, (1)
"Convenient to Sherman Hill and downtown. Quiet. "
United States
Abby H.
The price is ¥11,087
¥30,757 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Sleepover: Charming 1BD/1BA - Downtown Des Moines

Aparthotel in Downtown Des Moines

Kasa Downtown Des Moines
4.0 star property
9.2 out of 10, Wonderful, (111)
"Excellent stay! Very clean apartment and safe building."
United States
Bill
The price is ¥14,596
¥26,826 total
includes taxes & fees
Dec 28 - Dec 29
Kasa Downtown Des Moines

Apartment in Downtown Des Moines

Urban Jungle Retreat (417)
9.4 out of 10, Exceptional, (9)
"Very comfortable and convenient for a single traveler. "
United States
Jessica H.
The price is ¥7,797
¥21,850 total
includes taxes & fees
Dec 28 - Dec 29
Urban Jungle Retreat (417)
10.0 out of 10, Exceptional, (2)
"No issues, everything went very smoothly. Second tv in bedroom is nice if you like watching TV in bed"
United States
Kevin B.
The price is ¥10,136
¥26,100 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Modern Comfort Meets Affordable Luxury – Your Perfect Stay Awaits!

Apartment in Downtown Des Moines

Your home away from home
9.0 out of 10, Wonderful, (2)
"Had a good stay, the place was very nice. Only thing that was somewhat annoying was the parking situation since we got blocked by the train many times from getting to our car. Otherwise everything was excellent!"
United States
kylee
The price is ¥9,356
¥25,249 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Your home away from home

Apartment in Downtown Des Moines

Stunning Downtown Studio with Rooftop Patio
10.0 out of 10, Exceptional, (2)
"Just as advertised. Great communication and location. Plan to stay again during a future visit to the area."
United States
Ron D.
The price is ¥8,920
¥151,627 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Stunning Downtown Studio with Rooftop Patio
2.0 star property
The price is ¥10,136
¥26,100 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Family-Friendly 2BR with Amenities, WiFi & Parking

Apartment in Downtown Des Moines

Modern Studio - walk to Wells Fargo Arena
9.0 out of 10, Wonderful, (8)
"The location was perfect for the Iowa Events Center. Good apartment, and very clean."
United States
Hugo M.
The price is ¥8,405
¥150,876 total
includes taxes & fees
Dec 28 - Dec 29
Modern Studio - walk to Wells Fargo Arena

Apartment in Downtown Des Moines

Boho Loft / Skyline View / Walk to Arena Events
10.0 out of 10, Exceptional, (6)
"Wonderful location! "
United States
Travis
The price is ¥10,292
¥27,246 total
includes taxes & fees
Dec 29 - Dec 30
Boho Loft / Skyline View / Walk to Arena Events

Vacation Home in Greater South Side

Family & Pet-Friendly 2BR Retreat Near Downtown
10.0 out of 10, Exceptional, (12)
"Great location and had everything we needed! "
United States
Cooper R.
The price is ¥14,035
¥38,773 total
includes taxes & fees
Dec 29 - Dec 30
Family & Pet-Friendly 2BR Retreat Near Downtown

Apartment in Downtown Des Moines

2 BR Dwntwn Apt with Hot Tub
9.0 out of 10, Wonderful, (9)
"It was a great location for Ironman 70.3. Just a little over a mile or so from both Greys lake and the finish line. I would stay there again!! Des Moines was a great experience. "
United States
Rob M.
The price is ¥12,179
¥159,269 total
includes taxes & fees
Dec 28 - Dec 29
2 BR Dwntwn Apt with Hot Tub
10.0 out of 10, Exceptional, (6)
"Very secure quiet stay"
United States
Christine H.
The price is ¥10,772
¥25,978 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Sky Condo - 13th Floor 2br/1ba In Central Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Des Moines Hotel Reviews

Find out more about Des Moines

Search for holiday rentals in Des Moines on Expedia! You can easily find your home rentals, villas, holiday apartments in Des Moines using one of the methods below:

  • View our selection of featured holiday rentals in Des Moines
  • Use the map to find apartments and other holiday homes in the Des Moines neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Des Moines while they last

Look no further and take a look at our great range of rental properties in Des Moines!

Frequently asked questions

Can I find a vacation rental in Des Moines?

Yes, you can find vacation rentals in Des Moines close to Science Center of Iowa, or you can choose a secluded option if you're looking for extra privacy while you relax. Travelers who like culture and the arts give Des Moines high marks for its lively festivals and great live music. Leave some time to check out the acclaimed theater scene and top-notch restaurants during your visit.

What are some of the best vacation home rentals that Des Moines has to offer?

LUXURY GETAWAY! ARCADE, POOL TBL, PING PONG, HOT TUB, DECK! ACCESS TO POOLS!: Visitors give good reviews to this Des Moines vacation home rental, which is located next to a golf course and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. It offers a garden, a selection of games, and a hot tub so you can immerse yourself in your vacation. Some other top choices in Des Moines are AMAZING & A PARTY BARN… HOT TUB, PL TBl, PNG PNG, & ARCADE! ACCESS TO POOLS! and Beautiful home minutes from downtown! .

How many vacation rentals are there in Des Moines?

With 259 Expedia vacation rentals, you're sure to find just the right place for your Des Moines stay.

What’s there to see and do in Des Moines?

Enjoy the outdoors at Greater Des Moines Botanical Garden and John and Mary Pappajohn Sculpture Park, or simply take in cultural attractions like World Food Prize Hall of Laureates and Wooly's. Walnut Street Bridge and Des Moines Civic Center are other places to visit while you're in town.

What’s a vacation rental in Des Moines like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Des Moines. Vacation rentals offer extras such as patios, hot tubs, and fire pits so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can offer a sense of privacy away from shared hotel elevators and busy lobbies while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for small groups.