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Compare 197 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 star property
9.0 out of 10, Wonderful, 289 reviews
"Hotel is great. Service is better. Rooms by the pool, which should be the centerpiece of the property, are a bit dated. Bed was just ok. Comfortable enough but not great. "
The price is ¥21,328
per night
Jul 6 - Jul 7
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Hotel LP Equipetrol
3.5 star property
8.2 out of 10, Very Good, 186 reviews
"The property is good. My only problem was the wifi which in my room was very poor and in other areas very slow."
The price is ¥10,687
per night
Jun 16 - Jun 17
Hotel LP Equipetrol
Marriott Santa Cruz de la Sierra Hotel
5.0 star property
8.8 out of 10, Excellent, 151 reviews
"Clean comfortable room and beds. Nice fitness center. Small pool and hot tub could be hotter. Munimal vegan options at restaurant but lots of other places nearby. "
The price is ¥16,058
per night
Jul 6 - Jul 7
Marriott Santa Cruz de la Sierra Hotel
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Camino Real Hotel
4.5 star property
8.8 out of 10, Excellent, 329 reviews
"Nice hotel and nice area around. Many restaurants. Walkable "
The price is ¥20,105
per night
Jun 16 - Jun 17
Camino Real Hotel
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
9.2 out of 10, Wonderful, 196 reviews
"It’s an awesome place. Location couldn’t be better. Restaurants, cafes, shopping all within walking distance. Neighborhoods to walk around a get to know. Easy transportation to historic downtown and very reasonable cost. "
The price is ¥13,267
per night
Jun 22 - Jun 23
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
TRYP by Wyndham Santa Cruz
4.0 star property
9.4 out of 10, Exceptional, 82 reviews
"Great location, lobby was nice but room itself had very thin walls and door. Only drawbacks. A bit odd was the hallway lights were on movement detection mode so it was odd to step out of the elevator to a completely dark hallway "
The price is ¥10,530
per night
Jun 29 - Jun 30
TRYP by Wyndham Santa Cruz
Hotel G
3.5 star property
7.8 out of 10, Good, 89 reviews
"Everything was great. Only down side was the construction being infront of the hotel. But the location is good area. "
The price is ¥7,258
per night
Jun 16 - Jun 17
Hotel G
Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
9.2 out of 10, Wonderful, 60 reviews
"Great service. Very nice and accommodating staffs "
The price is ¥7,368
per night
Jun 26 - Jun 27
Premium Suites Deluxe Aparthotel Equipetrol
Novotel Santa Cruz De La Sierra
5.0 star property
9.2 out of 10, Wonderful, 64 reviews
"Nice hotel, clean, modern and very comfortable. Nice view. The best option for a solo traveler or business trip in Santa Cruz"
The price is ¥14,898
per night
Jun 29 - Jun 30
Novotel Santa Cruz De La Sierra
Sun Hotel
3.5 star property
8.4 out of 10, Very Good, 249 reviews
"Great place"
The price is ¥16,937
per night
Jun 22 - Jun 23
Sun Hotel
Ibis Santa Cruz DE LA Sierra
3.0 star property
9.8 out of 10, Exceptional, 27 reviews
"I had a great stay at this hotel. It has a good location, within reasonable walking distance to the old town or the restaurant area, though Uber is very easy and cheap. The hotel is good, modern and clean . The ambience is very quiet , I would have liked a more interesting and lively vibe. The room was very spacious and comfortable. The only downside was that my room did not have a mini-fridge. The front desk staff was very helpful and kind. "
The price is ¥9,330
per night
Jul 1 - Jul 2
Ibis Santa Cruz DE LA Sierra
Fiori Apartment
3.5 star property
9.2 out of 10, Wonderful, 73 reviews
"Front desk clerk was very friendly and handful."
The price is ¥5,633
per night
Jun 18 - Jun 19
Fiori Apartment
Hotel Cortez
3.5 star property
9.2 out of 10, Wonderful, 74 reviews
"Super good hotel!"
The price is ¥16,662
per night
Jun 22 - Jun 23
Hotel Cortez
Swissôtel Santa Cruz De La Sierra
4.5 star property
9.0 out of 10, Wonderful, 41 reviews
"Good"
The price is ¥14,788
per night
Jun 22 - Jun 23
Swissôtel Santa Cruz De La Sierra
Hotel LP Santa Cruz Centro
3.0 star property
7.8 out of 10, Good, 275 reviews
"Clean, friendly staff"
The price is ¥9,315
per night
Jun 22 - Jun 23
Hotel LP Santa Cruz Centro
Hostal Killa
3.0 star property
The price is ¥3,457
per night
Jun 15 - Jun 16
Hostal Killa
HOTEL OSHO
3.5 star property
8.6 out of 10, Excellent, 18 reviews
"I like his service "
The price is ¥10,954
per night
Jun 25 - Jun 26
HOTEL OSHO
Delfines Collection Hotel By Mercure
3.5 star property
8.4 out of 10, Very Good, 23 reviews
"Buena ubicación. Personal amable. Lugar tranquilo. Habitaciones confortables. "
The price is ¥6,055
per night
Jun 21 - Jun 22
Delfines Collection Hotel By Mercure
Alojamiento Oasis
2.5 star property
6.4 out of 10, 5 reviews
"Nadie fue cordial. Había mucho ruido "
The price is ¥2,195
per night
Jun 21 - Jun 22
Alojamiento Oasis
Equipetrol Suites Apart Hotel
2.5 star property
6.0 out of 10, 2 reviews
"Habian bichos en la habitacion, sabanas con manchas, en general no muy bueno."
The price is ¥6,754
per night
Jun 24 - Jun 25
Equipetrol Suites Apart Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Cruz attractions

Santa Cruz hotels information

Number of reviews
2,220
Accommodation
197 hotels
Lowest Price
¥2,195
Highest Price
¥21,328

Frequently asked questions

What's the best place for a stay in Santa Cruz?

Alfonsina Hotel Boutique by Inboccaluppo is a favorite with Expedia customers. This hotel offers free breakfast and a restaurant. Reviews from our site also recommend TRYP by Wyndham Santa Cruz and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia as top options for your trip. See all available top hotels, or vacation rentals in Santa Cruz.

What's the top vacation rental that Santa Cruz has to offer?

Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Make the most of the private yard in this rental home to help you unwind. Some other homes for rent in Santa Cruz include Mi casa su casa, moderna y chic. and Cozy and independent.
Downtown house JH.
. See all vacation rentals in Santa Cruz.

If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?

Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.

Where can I learn more about changing or cancelling my trip to Santa Cruz?

To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.

What's the best budget-friendly accommodation in Santa Cruz?

Based on our traveler reviews, Hostal Killa is a top choice for a less expensive stay. Other choices for your budget-friendly stay include residencial francia - Hostel and Residencial Ikandire II. View all budget hotels in Santa Cruz.

What's the best accommodation for a family trip to Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a hotel with an outdoor pool and a restaurant, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Camino Real Hotel. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.

What's the best place to stay for a romantic vacation to Santa Cruz?

Buganvillas Hotel Suites & Spa is a favorite 4-star hotel for couples, and features in-room massages and rainfall showerheads. See all romantic hotels in Santa Cruz.

What is the top LGBTQ-friendly accommodation in Santa Cruz?

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santa Cruz.

What's the best pet-friendly hotel in Santa Cruz?

Hotel LP Equipetrol is a top hotel for people traveling with their pets, and offers a restaurant and concierge services for its human guests. Other good options for you and your pet's trip include Ibis Santa Cruz DE LA Sierra and Swissôtel Santa Cruz De La Sierra. See more pet-friendly hotel accommodations in Santa Cruz.

Where is the best place to stay close to Plaza 24 de Septiembre?

Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.

What about the best place to stay near Ventura Mall?

One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.

What's the best luxury accommodation in Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Camino Real Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.

Recent reviews of Santa Cruz hotels
Expedia verified reviews