Find 4 Star Hotels in Southern Indiana from ￥15,714

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Check availability on Southern Indiana 4 Star Hotels

Tonight
Dec 27 - Dec 28
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Dec 28 - Dec 29
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Jan 2 - Jan 4
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Jan 9 - Jan 11

Our top choices for Southern Indiana 4-star hotels

4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (3898)
"Great place to stay! "
United States
Rochelle
The price is ￥20,871
￥24,557 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Galt House Hotel Trademark Collection by Wyndham
Sauna, body treatments, aromatherapy, hot stone massages
Omni Louisville Hotel

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1745)
"This is a beautiful hotel in a great location. Very kind staff and helpful with directions."
United States
Bonnie
The price is ￥26,179
￥30,803 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Omni Louisville Hotel
Dinner served
Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1125)
"Staff was courteous, hotel was beautiful and clean, and breakfast was amazing!"
United States
Shunskis
The price is ￥19,130
￥22,508 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Embassy Suites Louisville Downtown
Lobby
The Brown Hotel

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1162)
"Fantastic place to stay in Louisville."
United States
Nathaniel
The Brown Hotel
Hypo-allergenic bedding, in-room safe, desk, laptop workspace
Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1019)
"Great location and accommodations."
United States
Steve
The price is ￥19,884
￥23,396 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hotel Genevieve part of JdV by Hyatt
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1002)
"Staff was very kind, the art was fantastic, location was perfect to explore Whiskey Row, and we had a gorgeous room. Loved our time away there!"
United States
Tammy
The price is ￥21,763
￥26,387 total
includes taxes & fees
Jan 1 - Jan 2, 2026
21c Museum Hotel Louisville
Breakfast, lunch and dinner served
Hyatt Regency Louisville

Hyatt Regency Louisville

Hyatt Regency Louisville
4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1001)
"Enjoyed our stay "
United States
Jedediah
The price is ￥19,884
￥23,396 total
includes taxes & fees
Dec 29 - Dec 30
Hyatt Regency Louisville
Deluxe Single Room, 1 King Bed, River View | View from room
The Grady

The Grady

The Grady
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1006)
"Such an amazing hotel...restaurant is delicious! "
United States
Craig
The price is ￥22,687
￥26,693 total
includes taxes & fees
Jan 3 - Jan 4, 2026
The Grady
Restaurant
Louisville Marriott Downtown

Louisville Marriott Downtown

Louisville Marriott Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1000)
"Very nice hotel. Great stay!"
United States
Brad
The price is ￥26,257
￥30,894 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Louisville Marriott Downtown
Exterior
Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (428)
"Great location. Great restraunt, great staff. Pleasurable experience!"
United States
Harrison
The price is ￥27,420
￥32,262 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hotel Distil, Autograph Collection
View from room
DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville
4.0 star property
Downtown Evansville
8.6 out of 10, Excellent, (1001)
"The staff were extremely friendly "
United States
Jill
The price is ￥15,278
￥17,569 total
includes taxes & fees
Jan 4 - Jan 5, 2026
DoubleTree by Hilton Evansville
Exterior
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (58)
"Amazing property! Best hotel in Louisville! Will be staying there again!"
United States
Norman
The price is ￥26,357
￥31,011 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Lobby
Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
4.0 star property
Downtown Louisville
8.6 out of 10, Excellent, (1003)
"Excellent location and a great lobby bar with a top notch bourbon selection. "
United States
vincent
The price is ￥22,518
￥26,495 total
includes taxes & fees
Dec 30 - Dec 31
Seelbach Hilton Louisville Downtown
Signature Suite, 1 Queen Bed, Non Smoking | Premium bedding, down comforters, memory foam beds
Stellar Suites

Stellar Suites

Stellar Suites
4.5 star property
Downtown Louisville
9.6 out of 10, Exceptional, (117)
"Clean and great location "
United States
Greg
The price is ￥16,256
￥27,046 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Stellar Suites
Deluxe Room, 1 King Bed (Culbertson Suite) | Balcony
The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
4.0 star property
New Albany
9.8 out of 10, Exceptional, (649)
"Awesome place to stay! "
United States
Richard
The price is ￥13,907
￥15,714 total
includes taxes & fees
Dec 29 - Dec 30
The Pepin Mansion Historic B&B
Seasonal outdoor pool
CozySuites at Nulu

CozySuites at Nulu

CozySuites at Nulu
4.0 star property
Downtown Louisville
8.2 out of 10, Very Good, (26)
"The unit was clean, all communications were timely, the property has all the amenities, and NULU is very walkable. A perfect stay! My only regret is that I wasn't able to extend the stay. Highly recommended if you're in the Louisville area "
United States
William
The price is ￥9,371
￥29,050 total
includes taxes & fees
Jan 25 - Jan 26, 2026
CozySuites at Nulu
BBQ/picnic area
stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville
4.0 star property
Clarksville
9.8 out of 10, Exceptional, (43)
"Excellent stay. One of my favorite hotels in the area. They never disappoint "
United States
Julia
The price is ￥22,862
￥25,834 total
includes taxes & fees
Jan 1 - Jan 2, 2026
stayAPT Suites Louisville North-Clarksville
Full-size fridge, microwave, oven, stovetop
The Reserve on Main

The Reserve on Main

The Reserve on Main
4.0 star property
Downtown Louisville
10.0 out of 10, Exceptional, (1)
"Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. "
Canada
georgios
The price is ￥25,834
￥37,815 total
includes taxes & fees
Dec 30 - Dec 31
The Reserve on Main
Exterior detail
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
4.0 star property
Sellersburg
9.4 out of 10, Exceptional, (10)
"Very nice house in a nice neighborhood, spacious home environmental, felt more that at home there,"
United States
Tammy
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
Lounge
Holiday Inn Evansville Airport

Holiday Inn Evansville Airport

Holiday Inn Evansville Airport
4.0 star property
Evansville
8.0 out of 10, Very Good, (604)
"Nice hotel but it doesn’t have a fridge in the room or microwave."
United States
Anonymous traveler
Holiday Inn Evansville Airport
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Learn more about Southern Indiana

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Belle of Louisville featuring a bay or harbor and a ferry as well as a small group of people

Top Southern Indiana Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Southern Indiana?
Based on reviews by our guests, Galt House Hotel Trademark Collection by Wyndham is among the best 4-star hotels in Southern Indiana. Situated in Louisville, it includes massage services and beauty services. Hyatt Regency Louisville is another sought-after option here. Also with a 4-star rating and offering premium bedding and designer toiletries, you're sure to have a comfortable stay.
How much does it cost to stay in a 4-star hotel in Southern Indiana?
To book a 4-star hotel in Southern Indiana that's within your budget, take advantage of Expedia's handy filters. Take a look at what's available during your preferred dates and use our pricing filter to set your limit. You can also sort your results by the most budget-friendly option first.

  • Search for the lowest price from ￥15,714

What's the difference between 5-star and 4-star hotels in Southern Indiana?
Give yourself the luxury treatment during your Southern Indiana escape by checking in to a 4-star hotel. As well as featuring upmarket surroundings, these properties are typically packed with amenities such as large beds, bathrobes and plenty more. A 5-star hotel will go the extra mile to make your stay an even more indulgent and memorable one. 24-hour concierge assistance, luxurious spas and world-class dining are a few of the exclusive services and conveniences you'll likely be able to enjoy.