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Check availability on Southern Indiana 4 Star Hotels

Our top choices for Southern Indiana 4-star hotels

4 restaurants, breakfast, lunch, dinner served; American cuisine

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,080 reviews)
"Rooms were clean and staff were friendly! "
United States
Amy
The price is ￥23,827
￥28,035 total
includes taxes & fees
Mar 19 - Mar 20
Galt House Hotel Trademark Collection by Wyndham
3 bars/lounges, cocktail bar, lobby lounge

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1,775 reviews)
"Amazing stay! "
United States
Erin
The price is ￥30,419
￥35,791 total
includes taxes & fees
Mar 19 - Mar 20
Omni Louisville Hotel
Reception

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1,159 reviews)
"Great room and breakfast. Close to several nice restaurants."
United States
Crystal
The price is ￥17,519
￥20,613 total
includes taxes & fees
Mar 8 - Mar 9
Embassy Suites Louisville Downtown
Interior

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,191 reviews)
"Beautiful old hotel with a fantastic bar in the lobby"
United States
Karen
The Brown Hotel
Terrace/patio

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1,040 reviews)
"Spotless room and courteous staff "
United States
Mary
The price is ￥20,615
￥24,256 total
includes taxes & fees
Feb 26 - Feb 27
Hotel Genevieve part of JdV by Hyatt
Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,006 reviews)
"Great room, super kind staff"
United States
Rachel
The price is ￥27,333
￥32,925 total
includes taxes & fees
Feb 17 - Feb 18
21c Museum Hotel Louisville
Lobby

Hyatt Regency Louisville

Hyatt Regency Louisville
4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1,002 reviews)
"Everything was just excellent on the day I stayed."
United States
Peggy
The price is ￥22,600
￥26,591 total
includes taxes & fees
Feb 28 - Mar 1
Hyatt Regency Louisville
Lobby

The Grady

The Grady
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,002 reviews)
"Such an amazing hotel...restaurant is delicious! "
United States
Craig
The price is ￥56,194
￥66,119 total
includes taxes & fees
Mar 7 - Mar 8
The Grady
Exterior

Louisville Marriott Downtown

Louisville Marriott Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1,000 reviews)
"Very nice hotel. Great stay!"
United States
Brad
The price is ￥31,387
￥36,929 total
includes taxes & fees
Mar 15 - Mar 16
Louisville Marriott Downtown
Terrace/patio

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (445 reviews)
"Exceptionally handsome hotel design, extraordinary restaurant and service, fantastic location. "
United States
Carol
The price is ￥29,723
￥34,973 total
includes taxes & fees
Mar 8 - Mar 9
Hotel Distil, Autograph Collection
Lobby

DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville
4.0 star property
Downtown Evansville
8.6 out of 10, Excellent, (1,004 reviews)
"The staff were extremely friendly "
United States
Jill
The price is ￥14,900
￥17,135 total
includes taxes & fees
Feb 22 - Feb 23
DoubleTree by Hilton Evansville
Exterior

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (72 reviews)
"i love this place"
United States
THANH
The price is ￥27,973
￥32,912 total
includes taxes & fees
Feb 28 - Mar 1
Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Exterior

Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
4.0 star property
Downtown Louisville
8.6 out of 10, Excellent, (1,002 reviews)
"The area was congested but the motel was good. "
United States
Byrd
The price is ￥22,618
￥26,612 total
includes taxes & fees
Feb 26 - Feb 27
Seelbach Hilton Louisville Downtown
Lounge

Stellar Suites

Stellar Suites
4.5 star property
Downtown Louisville
9.6 out of 10, Exceptional, (121 reviews)
"The check-in process was simple and easy, the room was spotless and had so many amenities. "
United States
Grace
The price is ￥17,657
￥28,471 total
includes taxes & fees
Mar 3 - Mar 4
Stellar Suites
Property entrance

The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
4.0 star property
New Albany
9.8 out of 10, Exceptional, (665 reviews)
"The room was fantastic. Great location. Breakfast was excellent!! Mimi, the innkeeper, was gracious and very helpful with restaurant recommendations. Truly enjoyed my stay. "
United States
Kimberly
The price is ￥13,563
￥15,326 total
includes taxes & fees
Feb 18 - Feb 19
The Pepin Mansion Historic B&B
Seasonal outdoor pool

CozySuites at Nulu

CozySuites at Nulu
4.0 star property
Downtown Louisville
8.0 out of 10, Very Good, (27 reviews)
"The unit was clean, all communications were timely, the property has all the amenities, and NULU is very walkable. A perfect stay! My only regret is that I wasn't able to extend the stay. Highly recommended if you're in the Louisville area "
United States
William
The price is ￥10,009
￥29,342 total
includes taxes & fees
Mar 17 - Mar 18
CozySuites at Nulu
Exterior

stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville
4.0 star property
Clarksville
9.8 out of 10, Exceptional, (46 reviews)
"room very good i love hotel ❤️"
United States
Kartar
stayAPT Suites Louisville North-Clarksville
32-inch Smart TV with cable channels

The Reserve on Main

The Reserve on Main
4.0 star property
Downtown Louisville
10.0 out of 10, Exceptional, (1 review)
"Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. "
Canada
georgios
The price is ￥25,196
￥36,881 total
includes taxes & fees
Feb 18 - Feb 19
The Reserve on Main
Family House, Multiple Beds | Private kitchen | Fridge, microwave, oven, stovetop

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
4.0 star property
Sellersburg
9.4 out of 10, Exceptional, (10 reviews)
"Very nice house in a nice neighborhood, spacious home environmental, felt more that at home there,"
United States
Tammy
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
Lounge

Holiday Inn Evansville Airport

Holiday Inn Evansville Airport
4.0 star property
Evansville
8.0 out of 10, Very Good, (604 reviews)
"Nice hotel but it doesn’t have a fridge in the room or microwave."
United States
Anonymous traveler
Holiday Inn Evansville Airport
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Learn more about Southern Indiana

Live music, casinos, and top sights like KFC Yum Center—discover it all in Southern Indiana.

See all hotels in Southern Indiana
Belle of Louisville featuring a bay or harbor and a ferry as well as a small group of people

Top Southern Indiana Hotel Reviews

DoubleTree by Hilton Evansville

DoubleTree by Hilton Evansville

10/10 Excellent
"Didnt eat breakfast. "
Steven 1-night trip
Posted 2 months ago
DoubleTree by Hilton Evansville

Frequently asked questions

What are the best 4-star hotels in Southern Indiana?
Based on reviews by our guests, Galt House Hotel Trademark Collection by Wyndham is among the best 4-star hotels in Southern Indiana. Situated in Louisville, it includes massage services and beauty services. Hyatt Regency Louisville is another sought-after option here. Also with a 4-star rating and offering premium bedding and designer toiletries, you're sure to have a comfortable stay.
How much does it cost to stay in a 4-star hotel in Southern Indiana?
To book a 4-star hotel in Southern Indiana that's within your budget, take advantage of Expedia's handy filters. Take a look at what's available during your preferred dates and use our pricing filter to set your limit. You can also sort your results by the most budget-friendly option first.

  • Search for the lowest price from ￥15,326

What's the difference between 5-star and 4-star hotels in Southern Indiana?
Give yourself the luxury treatment during your Southern Indiana escape by checking in to a 4-star hotel. As well as featuring upmarket surroundings, these properties are typically packed with amenities such as large beds, bathrobes and plenty more. A 5-star hotel will go the extra mile to make your stay an even more indulgent and memorable one. 24-hour concierge assistance, luxurious spas and world-class dining are a few of the exclusive services and conveniences you'll likely be able to enjoy.