A beach with palm trees, people relaxing on chairs, and colorful kayaks.

Find 4 Star Hotels in Florida Keys from ¥34,275

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Florida Keys 4 Star Hotels

Next weekend
In two weeks

Our top choices for Florida Keys 4-star hotels

Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
4.0 star property
Key Largo
8.6 out of 10, Excellent, (1,118 reviews)
"Great stay over Spring Break. Beautiful place!"
United States
Angela
The price is ¥48,499
¥63,477 total
includes taxes & fees
Jul 1 - Jul 2
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Amara Cay Resort

Amara Cay Resort
4.0 star property
Matecumbe
8.8 out of 10, Excellent, (1,285 reviews)
"Good place to stay, very friendly staff and great breakfast!"
United Kingdom
Christos
The price is ¥28,328
¥43,697 total
includes taxes & fees
Jul 21 - Jul 22
Amara Cay Resort

Reefhouse Resort & Marina

Reefhouse Resort & Marina
4.5 star property
Key Largo
9.4 out of 10, Exceptional, (1,475 reviews)
"We loved this place! The view, the access to everything, the food, would definitely stay here again!"
United States
Thomas
The price is ¥38,656
¥49,959 total
includes taxes & fees
Jul 12 - Jul 13
Reefhouse Resort & Marina

Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
9.0 out of 10, Wonderful, (1,007 reviews)
"Our favorite hotel in the FL Keys"
United States
Jose
The price is ¥49,007
¥64,050 total
includes taxes & fees
Jul 16 - Jul 17
Playa Largo Resort & Spa, Autograph Collection

Islander Resort

Islander Resort
4.0 star property
Matecumbe
9.4 out of 10, Exceptional, (1,063 reviews)
"Beautiful rooms and resort."
United States
Neha
The price is ¥42,311
¥58,517 total
includes taxes & fees
Jul 22 - Jul 23
Islander Resort

Hawks Cay Resort

Hawks Cay Resort
4.0 star property
Marathon
8.2 out of 10, Very Good, (1,002 reviews)
"Perfect for our family, staff was amazing and the property is beautiful"
United States
Kathryne
The price is ¥31,837
¥48,250 total
includes taxes & fees
Jul 19 - Jul 20
Hawks Cay Resort

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
4.0 star property
Marathon
8.6 out of 10, Excellent, (1,163 reviews)
"Amazing location and super pet friendly!"
United States
Thalia
The price is ¥25,057
¥34,275 total
includes taxes & fees
Jul 13 - Jul 14
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
4.0 star property
Marathon
8.8 out of 10, Excellent, (1,002 reviews)
"Fantastic place, great atmosphere, peaceful, fantastic staff and the view was great!"
United States
Michael J
The price is ¥40,612
¥56,154 total
includes taxes & fees
Jul 5 - Jul 6
Tranquility Bay Beachfront Hotel and Resort

La Siesta Resort & Villas

La Siesta Resort & Villas
4.0 star property
Matecumbe
8.6 out of 10, Excellent, (1,004 reviews)
"Our families really enjoyed our stay there new favorite"
United States
Marc
The price is ¥28,213
¥43,568 total
includes taxes & fees
Jul 1 - Jul 2
La Siesta Resort & Villas

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
4.0 star property
Islamorada
9.0 out of 10, Wonderful, (220 reviews)
"Room was beautiful, just as pictured on the website. It is a lovely place."
United States
CATHY
The price is ¥49,355
¥67,352 total
includes taxes & fees
Jul 16 - Jul 17
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Villas At Hawks Cay Resort

Villas At Hawks Cay Resort
4.0 star property
Marathon
8.2 out of 10, Very Good, (212 reviews)
"We had a great stay."
United States
Elise
The price is ¥125,349
¥151,026 total
includes taxes & fees
Jun 29 - Jun 30
Villas At Hawks Cay Resort

Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club
4.0 star property
Marathon
9.4 out of 10, Exceptional, (463 reviews)
"Great location, beautiful room with sea view balcony. Would stay again"
United Kingdom
Katherine
The price is ¥30,416
¥41,981 total
includes taxes & fees
Jun 29 - Jun 30
Grassy Flats Resort & Beach Club

The Islands of Islamorada

The Islands of Islamorada
4.0 star property
Matecumbe
9.6 out of 10, Exceptional, (76 reviews)
"What a wonderful venue for our last 2 nights in the Keys. This place is a hidden gem. The entire staff, especially Edith, the bartender, were fantastic."
United States
Michael
The price is ¥103,352
¥125,187 total
includes taxes & fees
Jul 6 - Jul 7
The Islands of Islamorada

The Reef at Marathon, Florida Keys

The Reef at Marathon, Florida Keys
4.0 star property
Marathon
9.2 out of 10, Wonderful, (33 reviews)
"Beautiful place and accessible to a nearby beach and restaurants. "
United States
Thomas
The Reef at Marathon, Florida Keys

Marlin Bay Resort & Marina

Marlin Bay Resort & Marina
4.5 star property
Marathon
10.0 out of 10, Exceptional, (3 reviews)
"Wonderful vacation!"
United States
Chardell
Marlin Bay Resort & Marina

Waterfront Luxury Villa

Waterfront Luxury Villa
4.0 star property
Marathon Shores
Waterfront Luxury Villa

Florida Keys Getaway w/ Stunning Ocean Views

Florida Keys Getaway w/ Stunning Ocean Views
4.0 star property
Long Key
Florida Keys Getaway w/ Stunning Ocean Views
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Florida Keys.
Still don't see what you're looking for?
See all properties in Florida Keys.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

A beach with palm trees, people relaxing on chairs, and colorful kayaks.

Top Florida Keys Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Florida Keys?
You'll discover a variety of 4-star hotels in Florida Keys, including in Key Largo. Playa Largo Resort & Spa, Autograph Collection is a customer favorite in this city that offers a tennis court and a sauna. Another stay that rates highly with travelers is Bakers Cay Resort Key Largo, Curio Collection by Hilton. Dining romance packages and private picnic options help make it their preferred choice.
How much does it cost to stay in a 4-star hotel in Florida Keys?
To find a 4-star hotel in Florida Keys that fits your budget, take advantage of Expedia's handy search filters. Take a look at the availability during your vacation dates and use our pricing filter to set your maximum rate. You can also sort your results by the most affordable retreat first.

  • Search for the lowest price from ¥48,038

What's the difference between 5-star and 4-star hotels in Florida Keys?
Offering a welcoming traveler experience and upmarket décor, 4-star hotels are an excellent option for your Florida Keys getaway. These types of accommodations generally feature loads of useful amenities that make it easy to unpack and relax — think pillowtop mattresses, pools and restaurants. Or live the high life at a 5-star hotel designed to spoil you with high-end perks and amenities. Concierge assistance, premium toiletries and fine dining are typically included at these deluxe properties.