Find 4 Star Hotels in Florida Keys from ¥24,465
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on Florida Keys 4 Star Hotels
Compare Florida Keys 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Hawks Cay Resort
Hawks Cay Resort
8.0 out of 10, Very Good, (1010)
The price is ¥44,775
¥60,836 total
includes taxes & fees
Sep 28 - Sep 29

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Baker's Cay Resort Key Largo, Curio Collection by Hilton
8.6 out of 10, Excellent, (1028)
The price is ¥39,088
¥52,178 total
includes taxes & fees
Oct 2 - Oct 3

Amara Cay Resort
Amara Cay Resort
8.8 out of 10, Excellent, (1258)
The price is ¥22,762
¥35,487 total
includes taxes & fees
Sep 28 - Sep 29

Islander Resort
Islander Resort
9.2 out of 10, Wonderful, (1019)
The price is ¥26,192
¥39,511 total
includes taxes & fees
Oct 2 - Oct 3

Playa Largo Resort & Spa, Autograph Collection
Playa Largo Resort & Spa, Autograph Collection
9.0 out of 10, Wonderful, (1001)
The price is ¥33,187
¥45,539 total
includes taxes & fees
Oct 2 - Oct 3

Tranquility Bay Beachfront Hotel and Resort
Tranquility Bay Beachfront Hotel and Resort
8.8 out of 10, Excellent, (1002)
The price is ¥35,827
¥49,973 total
includes taxes & fees
Oct 19 - Oct 20

La Siesta Resort & Villas
La Siesta Resort & Villas
8.6 out of 10, Excellent, (1006)
The price is ¥18,261
¥30,423 total
includes taxes & fees
Sep 28 - Sep 29

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
8.8 out of 10, Excellent, (1278)
The price is ¥21,378
¥29,912 total
includes taxes & fees
Oct 2 - Oct 3
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 5-star hotels
Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Florida Keys.

Cheeca Lodge & Spa
81801 Overseas Highway, Mile Marker 82, Marker 82, Islamorada, FL
The price is ¥12,818 per night from Oct 8 to Oct 9
¥12,818
¥24,465 total
Oct 8 - Oct 9
includes taxes & fees
9/10 Wonderful! (1,210 reviews)
Still don't see what you're looking for?
See all properties in Florida Keys.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Florida Keys
Swim with dolphins, snorkel over coral reefs, visit Ernest Hemingway’s home or just relax on a beach and enjoy the balmy climate of this beautiful group of islands.

Top Florida Keys Hotel Reviews

Islander Resort
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Florida Keys Hotels by Star Rating
Stay near popular Florida Keys attractions
- Hotels near Duval Street
- Hotels near Southernmost Point
- Hotels near Smathers Beach
- Hotels near Florida Keys Beaches
- Hotels near John Pennekamp Coral Reef State Park
- Hotels near Sombrero Beach
- Hotels near South Beach
- Hotels near Ernest Hemingway Home and Museum
- Hotels near Fort Zachary Taylor Historic State Park
- Hotels near Jimmy Johnson's Big Chill
- Hotels near Biscayne National Park
- Hotels near Baker's Cay Resort Beach
- Hotels near Seven Mile Bridge
- Hotels near Harry S. Truman Little White House
More Hotel Options in Florida Keys
- Adults Only Resorts & Hotels in Florida Keys
- Adventure Hotels in Florida Keys
- All-inclusive Hotel in Florida Keys
- Beach Hotels in Florida Keys
- Boutique Hotels in Florida Keys
- Business Hotels in Florida Keys
- Casinos in Florida Keys
- Cheap Hotels in Florida Keys
- Family Hotels in Florida Keys
- Gay friendly Hotels in Florida Keys
- Golf Hotels in Florida Keys
- Green Hotels in Florida Keys
- Historic Hotels in Florida Keys
- Hotel Wedding Venues in Florida Keys
- Hotel with a Concierge in Florida Keys
- Hotels with Bars in Florida Keys
- Hotels with Early Check-in in Florida Keys
- Hotels with Free Parking in Florida Keys
- Hotels with Hot Tubs in Florida Keys
- Hotels with Waterslides in Florida Keys
- Hotels with WiFi in Florida Keys
- Hotels with a Pool in Florida Keys
- Hotels with smoking rooms in Florida Keys
- Luxury Hotels in Florida Keys
- Pet-friendly Hotels in Florida Keys
- Resorts & Hotels with Spas in Florida Keys
- Romantic Hotels in Florida Keys
- Scuba Diving in Florida Keys
- Shopping Hotels in Florida Keys
- Ski Hotels in Florida Keys
More Accommodation Types in Florida Keys
- Vacation Homes in Florida Keys
- Condo Rentals in Florida Keys
- Villas in Florida Keys
- Apartments in Florida Keys
- Cottages in Florida Keys
- Aparthotels in Florida Keys
- Resorts in Florida Keys
- RV Parks in Florida Keys
- Houseboats in Florida Keys
- Motels in Florida Keys
- Cabin Rentals in Florida Keys
- Guest Houses in Florida Keys
- Lodges in Florida Keys
- B&B in Florida Keys
Explore more hotels
- Islander Resort
- The Pelican Key Largo Cottages
- Rock Reef Resort
- Waterside Suites & Marina
- Treasure Harbor
- Coconut Cay Resort & Marina
- Bayside Inn Key Largo
- Fairfield Inn & Suites by Marriott Marathon Florida Keys
- Ocean Pointe Suites at Key Largo
- Tranquility Bay Beachfront Hotel and Resort
- Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
- La Siesta Resort & Villas
- Captain Pips Marina & Hideaway
- Yacht Haven Marina
- Lime Tree Bay Resort
- Sunset Inn
- Banana Bay Resort & Marina
More ways to book
Expedia's Latest Trends
Hotels
Flights
Cars
Packages