Find hotels in Seneca, SC from ¥9,128

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Seneca hotels

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123
2.5 star property
Seneca
8.0 out of 10, Very Good, (668 reviews)
"Good available parking. Room clean. Breakfast was minimal, but good. The tub was slippery and needed a mat. I almost fell a couple of times. I would stay here again."
United States
Denise
The price is ¥11,989
¥14,144 total
includes taxes & fees
Jan 25 - Jan 26
Quality Inn Seneca Clemson Area US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,001 reviews)
"Great place to stay. "
United States
Gene
The price is ¥17,235
¥21,395 total
includes taxes & fees
Jan 19 - Jan 20
Lakeside Lodge Clemson

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (54 reviews)
"Excellent stay."
United States
Beonca
The price is ¥11,962
¥20,117 total
includes taxes & fees
Jan 22 - Jan 23
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 star property
Seneca
9.4 out of 10, Exceptional, (206 reviews)
"Spotless, friendly staff, great location. "
United States
Cari
The price is ¥19,031
¥20,933 total
includes taxes & fees
Jan 24 - Jan 25
Fairfield Inn & Suites Seneca Clemson Univ Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very Good, (645 reviews)
"The stay was amazing "
United States
Tabatha
The price is ¥14,650
¥16,116 total
includes taxes & fees
Jan 26 - Jan 27
Best Western Seneca-Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (724 reviews)
"Room was clean. Quiet place to rest. Lisa at the front desk was very helpful and very nice. "
United States
Teresa
The price is ¥11,023
¥12,125 total
includes taxes & fees
Feb 2 - Feb 3
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (670 reviews)
"Great place to stay"
United States
Jose
The price is ¥18,766
¥20,641 total
includes taxes & fees
Jan 25 - Jan 26
Hampton Inn & Suites Seneca-Clemson Area

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (803 reviews)
"Perfect stay for a weekend. Lots of shopping and restaurants nearby. Clean safe area annd the staff was wonderful!"
United States
Cindy
The price is ¥16,596
¥18,255 total
includes taxes & fees
Jan 25 - Jan 26
Tru by Hilton Seneca Clemson

Hampton Inn Hartwell

Hampton Inn Hartwell
2.5 star property
Hartwell
9.2 out of 10, Wonderful, (347 reviews)
"Great stay!"
United States
Daniel
The price is ¥14,166
¥17,081 total
includes taxes & fees
Jan 30 - Jan 31
Hampton Inn Hartwell

Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson
2.0 star property
Anderson
7.8 out of 10, Good, (1,004 reviews)
"Very nice we'll stay there again"
United States
Michael
The price is ¥9,946
¥11,041 total
includes taxes & fees
Jan 20 - Jan 21
Days Inn by Wyndham Anderson

Quality Inn Clemson near University

Quality Inn Clemson near University
2.5 star property
Anderson
7.0 out of 10, Good, (894 reviews)
"Bueno was "
Mexico
Alejandro
The price is ¥7,802
¥8,660 total
includes taxes & fees
Feb 10 - Feb 11
Quality Inn Clemson near University

Quality Inn & Suites Easley - Greenville

Quality Inn & Suites Easley - Greenville
2.5 star property
Easley
7.0 out of 10, Good, (393 reviews)
"The staff was pleasant and facility was clean."
United States
Eric
The price is ¥8,222
¥9,128 total
includes taxes & fees
Jan 24 - Jan 25
Quality Inn & Suites Easley - Greenville

Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson
2.0 star property
Anderson
8.2 out of 10, Very Good, (1,001 reviews)
"Room was clean, front desk people were very nice. "
United States
Caressa
The price is ¥11,962
¥13,278 total
includes taxes & fees
Jan 19 - Jan 20
Microtel Inn & Suites by Wyndham Anderson/Clemson

Baymont by Wyndham Easley/Greenville

Baymont by Wyndham Easley/Greenville
2.5 star property
Easley
7.4 out of 10, Good, (765 reviews)
"Easy access from the highway lot of restaurants around the hotel and staff is very friendly"
United States
brian
The price is ¥10,673
¥11,847 total
includes taxes & fees
Jan 20 - Jan 21
Baymont by Wyndham Easley/Greenville

Rodeway Inn Anderson North - Clemson

Rodeway Inn Anderson North - Clemson
2.0 star property
Anderson
7.8 out of 10, Good, (321 reviews)
"Room was spotless an the stay was great."
United States
Benito
The price is ¥10,278
¥11,409 total
includes taxes & fees
Jan 20 - Jan 21
Rodeway Inn Anderson North - Clemson

Carolina Camp Cedar

Carolina Camp Cedar
3.5 star property
Pickens
The price is ¥14,134
¥30,203 total
includes taxes & fees
Jan 19 - Jan 20
Carolina Camp Cedar

Hilton Garden Inn Anderson

Hilton Garden Inn Anderson
3.0 star property
Anderson
9.0 out of 10, Wonderful, (691 reviews)
"Rooms were clean, staff were friendly, and we had 2 good night’s sleep."
United States
Sadie
The price is ¥16,726
¥18,566 total
includes taxes & fees
Jan 25 - Jan 26
Hilton Garden Inn Anderson

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
2.5 star property
Anderson
9.0 out of 10, Wonderful, (586 reviews)
"It was great. Room was clean and staff was friendly. "
United States
Veronica
The price is ¥16,286
¥18,076 total
includes taxes & fees
Jan 25 - Jan 26
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
2.0 star property
Walhalla
7.6 out of 10, Good, (174 reviews)
"Older hotel with great staff. It was safe and provided a great place for a stop over on the way to TN. I would definitely stay here again. "
United States
Laura
The price is ¥10,079
¥11,237 total
includes taxes & fees
Feb 15 - Feb 16
Rodeway Inn & Suites Walhalla

Americas Best Value Inn Anderson, SC

Americas Best Value Inn Anderson, SC
2.0 star property
Anderson
6.0 out of 10, (155 reviews)
"Nice little motel with friendly owners. Beds were a little too firm and breakfast a bit lacking, but for the price, it was fine. We enjoyed our stay. "
United States
Heather
The price is ¥10,120
¥11,231 total
includes taxes & fees
Jan 20 - Jan 21
Americas Best Value Inn Anderson, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most.

Downtown

Downtown Seneca captures the essence of small-town Southern charm with its well-preserved railroad heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colorful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railroad memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.

Serenity Bay

Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained vacation rentals rather than hotels. While dining options are limited within the neighborhood, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

Pine Ridge Point

Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This neighborhood offers an authentic lakeside living experience without tourist crowds. Vacation rentals range from cozy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.

Indian Oaks

Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious sidewalks while listening to birdsong. Lake Keowee lies just beyond the neighborhood boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.

Stay near popular Seneca attractions

Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

Lake Keowee South Carolina

Top Seneca Hotel Reviews

More cheap stays in Seneca

Frequently asked questions

Where is the best place for a stay in Seneca?
Tru by Hilton Seneca Clemson is ranked highly by Expedia customers. This hotel offers free breakfast and free parking. Traveler reviews also recommend Lakeside Lodge Clemson and Hampton Inn & Suites Seneca-Clemson Area as top choices for your visit. See all available top hotels, or vacation rentals in Seneca.
What's the top vacation rental in Seneca?
Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock: Visitors give good reviews to this Seneca vacation home rental, which is located on a lake and has a patio, a private yard, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Some other homes for rent in Seneca include Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock and Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub. See all vacation rentals in Seneca.
If I need to cancel my hotel reservation in Seneca, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.
Where can I learn more about changing or cancelling my trip to Seneca?
To find more details about updating your trip to Seneca or cancelling it, click here.
What's the best place to stay for a family vacation to Seneca?
Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Attractions in the area like Ultimate Action Sports are also fun for the whole family. Find more child-friendly accommodations in Seneca.
What's the best LGBTQ-friendly place to stay in Seneca?
Hampton Inn & Suites Seneca-Clemson Area is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Tru by Hilton Seneca Clemson is another good choice for your stay. See all available hotels listed as LGBTQ-friendly in Seneca.
What's the best pet-friendly accommodation in Seneca?
Lakeside Lodge Clemson is a top hotel for people traveling with their pets, and offers a restaurant and a seasonal outdoor pool for its human guests. Other good choices to stay with your pet include Days Inn by Wyndham Seneca / Clemson Area and Tru by Hilton Seneca Clemson. See more pet-friendly hotel accommodations in Seneca.
What are some hotels with pools in Seneca?
Lakeside Lodge Clemson: Hotel located near Clemson University. Features free self parking, a seasonal outdoor pool, and complimentary wireless internet access. Quality Inn Seneca Clemson Area US-123 and Hampton Inn & Suites Seneca-Clemson Area are two additional hotels with an onsite pool. View all hotels with pools in Seneca.
What is the best accommodation for staying close to Greenville-Spartanburg International Airport (GSP)?
Wyndham Garden Greenville Airport is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and a restaurant. It's located 3.8 mi (6.1 km) from Greenville-Spartanburg Intl. Airport. Other good options near the airport include Best Western Greenville Airport Inn and Extended Stay America - Greenville - Airport.
What is staying in Seneca like?
Visitors to Seneca are sure to enjoy the sporting events, lakeside setting, and university setting. Welcoming and scenic, this city also attracts tourists with its coffeehouses. In Seneca, there are 289 hotels and other accommodations to choose from. Find out more about Seneca.
What should I do while I'm visiting Seneca?
Cultural venues include The Gauntlet and Oconee Community Theatre. Natural beauty is on display at Keowee Reservoir, Lake Keowee, and Lake Hartwell. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. Check out what more to see and do in Expedia's Seneca guide.
What's the weather like in Seneca?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 46°F. Average annual precipitation for Seneca is 62 inches.

Explore a world of travel with Expedia