Find hotels in Santo Tomé from ￥1,729

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Jul 18 - Jul 19
Tomorrow
Jul 19 - Jul 20
This weekend
Jul 18 - Jul 20
Next weekend
Jul 25 - Jul 27

Filter by

Guest rating
Guest rating
Star rating

Compare 133 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Santo Tomé

Head to Getulio Vargas Museum and Joao Goulart Museum—just two of the sights around Santo Tomé.

See all hotels in Santo Tomé

Top Santo Tomé Hotel Reviews

Frequently asked questions

What's the best place to stay in Santo Tomé?

Based on our traveler data, Condado Hotel Casino Santo Tomé is one of the top choices for your stay. This hotel offers a casino and free breakfast. Picturesque House with Views of the Uruguay River is another good choice for your visit. See all available top hotels, or vacation rentals in Santo Tomé.

What's the top vacation rental that Santo Tomé has to offer?

Picturesque House with Views of the Uruguay River: This Santo Tomé vacation home rental comes with air-conditioning so you can feel at home during your trip. See all vacation rentals in Santo Tomé.

If I need to cancel my hotel reservation in Santo Tomé, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santo Tomé.

Where can I learn more about changing or cancelling my trip to Santo Tomé?

For more details about updating your trip to Santo Tomé or cancelling it, click here.

What are some accommodations with pools in Santo Tomé?

Condado Hotel Casino Santo Tomé: Features a restaurant, a seasonal outdoor pool, and a bar. View all hotels with pools in Santo Tomé.

What is staying in Santo Tomé like?

Visitors to Santo Tomé are sure to find plenty to explore and enjoy. In Santo Tomé, there are 2 hotels and other accommodations to choose from. Find out more about Santo Tomé.

What should I see while I'm in Santo Tomé?

Places to visit in the wider area include Joao Goulart Museum and Getulio Vargas Museum. Check out what more to see and do in Expedia's Santo Tomé guide.

What's the weather like in Santo Tomé?

The hottest months are usually January and February with an average temp of 78°F, while the coldest months are July and June with an average of 60°F. The rainiest months in Santo Tomé are October, November, March, and January, with each month seeing an average of 8 inches of rainfall.