Find Family Hotels in Santee, SC

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Check availability on Santee Family Hotels

Our top choices for Santee family-friendly hotels

Property amenity
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
2.5 star property
Santee
9.8 out of 10, Exceptional, (1001)
"Clean, friendly staff, new, good value"
United States
Robert
The price is ￥18,845
￥20,918 total
includes taxes & fees
Dec 18 - Dec 19
Fairfield Inn & Suites by Marriott Santee
Exterior
Best Western Plus Santee Inn

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1000)
"Nice rooms and very good breakfast items."
United States
Stephen
The price is ￥18,401
￥20,425 total
includes taxes & fees
Dec 18 - Dec 19
Best Western Plus Santee Inn
Seasonal outdoor pool
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1001)
"Close to the highway with a safe location."
United States
Benjamin
The price is ￥16,018
￥17,780 total
includes taxes & fees
Dec 21 - Dec 22
Comfort Inn & Suites Santee
In-room safe, iron/ironing board, free WiFi, bed sheets
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.0 out of 10, Good, (676)
"The room was very nice. It was newly renovated and I loved the upgrade. The beds were comfortable and warm. We didn’t eat breakfast because we were meeting someone for breakfast. "
United States
Alice
The price is ￥9,566
￥10,619 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Travelodge by Wyndham Santee
Interior
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (37)
"Amazing host, comfy furniture, the fenced in yard was perfect for our fur babies! Hope to stay here again. 1.2 miles away from I-95! "
United States
Lauren B.
The price is ￥14,858
￥50,202 total
includes taxes & fees
Dec 17 - Dec 18
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Outdoor pool, a heated pool
Tranquil Getaways W/Heated Pool and Fishing

Tranquil Getaways W/Heated Pool and Fishing

Tranquil Getaways W/Heated Pool and Fishing
Elloree
8.4 out of 10, Very Good, (6)
"Great property the pool was so fun! Mostly stayed on the property and lounged around for a nice relaxing stay!"
United States
Tori P.
The price is ￥13,957
￥32,899 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Tranquil Getaways W/Heated Pool and Fishing
Desk, iron/ironing board, free WiFi, bed sheets
Econo Lodge Santee

Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (309)
"Check in was easy."
United States
Amy
The price is ￥9,823
￥10,903 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Econo Lodge Santee
Free daily continental breakfast
Peach Tree Inn

Peach Tree Inn

Peach Tree Inn
2.5 star property
St. George
7.2 out of 10, Good, (136)
"Air conditioning very good, check in easy, staff very pleasant"
United States
Linda
Peach Tree Inn
Room, 2 Queen Beds, Accessible, Non Smoking (Efficiency) | Desk, iron/ironing board, free cribs/infant beds, free WiFi
Comfort Inn & Suites Orangeburg

Comfort Inn & Suites Orangeburg

Comfort Inn & Suites Orangeburg
2.5 star property
Orangeburg
8.0 out of 10, Very Good, (549)
"Would recommend this hotel for out of town guest with no hesitation. "
United States
Yvette
The price is ￥14,826
￥16,456 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Comfort Inn & Suites Orangeburg
Lobby
Sleep Inn Orangeburg

Sleep Inn Orangeburg

Sleep Inn Orangeburg
2.5 star property
Orangeburg
7.6 out of 10, Good, (381)
"Courteous staff"
United States
David
The price is ￥11,729
￥13,019 total
includes taxes & fees
Dec 26 - Dec 27
Sleep Inn Orangeburg
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Santee Hotel Reviews

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

10/10 Excellent
"Was able to walk to convenience store and other dinning alternatives. Safe secure building"
Joan 1-night trip
Posted 9 days ago
Holiday Inn Santee by IHG

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Frequently asked questions

What's Santee like for family-friendly vacations?
The welcoming destination of Santee is a great choice if you've been thinking about a vacation with the kids. The excursions, lake views, and golfing are just a few things that make this an attractive vacation spot for families. Arrange a flight into Columbia Metropolitan Airport (CAE), which is located 49 mi (78.8 km) from the city center.
What's the best place to stay for families in Santee?
Fairfield Inn & Suites by Marriott Santee is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Comfort Inn & Suites Santee is another choice for your stay with the kids.
When's the best time to book a family-friendly vacation in Santee?
The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Santee is 55 inches.
What's there to see and do with your family in Santee?
While you and your family are visiting Santee, you might want to check out some kid-friendly attractions such as Santee Indian Mound and Fort Watson Site and Orangeburg County Library Mentor Branch. Make sure you have lots of time for activities like Lake Marion and Taw Caw Creek.