An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Santee Vacation Rentals

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Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Santee vacation rentals

A spacious living room with a large sofa, two coffee tables, and a potted plant.

1. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (47 reviews)
"Comfortable home with fenced in yard for dogs is a plus. The house had everything needed for a stay. Furniture was comfy. House is an hour drive from congaree NP. Many opportunities nearby to connect with nature."
United States
Jessica C.
The price is ￥15,435
￥48,679 total
includes taxes & fees
Nov 11 - Nov 12
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
A covered patio with outdoor furniture, a view of a lake, and a sunset.

2. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
9.0 out of 10, Wonderful, (8 reviews)
"We had a wonderful stay. Couldn't have asked for better location. It was beautiful, close to everything and perfect for our family."
United States
Michelle H.
The price is ￥29,699
￥73,100 total
includes taxes & fees
Nov 5 - Nov 6
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
A multi-story residential building with balconies, a stone retaining wall, and a wooden deck.

3. Lake Marion Condo, Boat Slip Included, Pet Friendly

Lake Marion Condo, Boat Slip Included, Pet Friendly
Santee
10.0 out of 10, Exceptional, (1 review)
"My husband, son and I booked a relatively last-minute weekend trip. Gabriel was great, and fast about answering my questions. The unit was easy to find and gain entry to. It is very clean, quiet, and accessible to the water; a very short walk to the on-prem docks and the covered porch is very nice. We had an enjoyable stay and liked the area."
United States
Katie A.
The price is ￥27,631
￥51,877 total
includes taxes & fees
Nov 6 - Nov 7
Lake Marion Condo, Boat Slip Included, Pet Friendly
A wicker outdoor seating area with cushioned chairs and a matching ottoman on a porch.

4. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (16 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
The price is ￥36,315
￥76,413 total
includes taxes & fees
Nov 15 - Nov 16
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
A tent with a view of a lake and boats, a wooden chair, and a potted plant.

5. Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (103 reviews)
"Love it"
United States
Mark
The price is ￥11,706
￥13,467 total
includes taxes & fees
Nov 5 - Nov 6
Bells Marina & Resort
A covered outdoor seating area with a view of a dock and boats, wooden furniture, and string lights.

6. Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
Summerton
8.8 out of 10, Excellent, (41 reviews)
"Great place to stay on the lake! "
United States
Troy S.
The price is ￥12,789
￥25,062 total
includes taxes & fees
Nov 11 - Nov 12
Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
A kitchen with wooden cabinets, a built-in dishwasher, a sink, and a ceiling fan.

7. Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
9.8 out of 10, Exceptional, (37 reviews)
"The place was excellent. The bed was really nice and comfortable. I'd definitely stay again."
United States
Joseph
The price is ￥12,079
￥24,276 total
includes taxes & fees
Nov 5 - Nov 6
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
A compact living space with a kitchen, dining area, and a small seating area.

8. Country living lake style near Santee

Country living lake style near Santee
Summerton
10.0 out of 10, Exceptional, (47 reviews)
"Very convenient to the lake."
United States
John P.
The price is ￥17,210
￥34,876 total
includes taxes & fees
Nov 8 - Nov 9
Country living lake style near Santee
A wooden cabin with a porch, a bench, and a potted plant.

9. Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.

Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.
Summerton
10.0 out of 10, Exceptional, (3 reviews)
"This was first VRBO and it was exactly as planned and expected ! Thank you Ronald !"
United States
Jeff B.
The price is ￥22,594
￥43,131 total
includes taxes & fees
Nov 10 - Nov 11
Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.
A wooden cabin with a porch and picnic table in a wooded area.

10. Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Rimini
8.2 out of 10, Very good, (17 reviews)
"Great place to stay. "
United States
Scott J.
The price is ￥13,500
￥20,771 total
includes taxes & fees
Nov 17 - Nov 18
Cozy Camping Cabin on Lake Marion near Congaree Nat Park
A modern kitchen with stainless steel appliances, white cabinetry, and a wooden floor.

11. Quiet 1-bedroom apartment in charming Elloree, SC

Quiet 1-bedroom apartment in charming Elloree, SC
Elloree
The price is ￥19,736
￥29,618 total
includes taxes & fees
Nov 13 - Nov 14
Quiet 1-bedroom apartment in charming Elloree, SC
A small cabin with a fire pit, outdoor seating, and string lights.

12. Cabin at the lake in Rimini, SC

Cabin at the lake in Rimini, SC
Rimini
7.4 out of 10, Good, (8 reviews)
"Great view, excellent communication with the owners, relaxing, peaceful. "
United States
Christie
The price is ￥12,647
￥20,172 total
includes taxes & fees
Nov 5 - Nov 6
Cabin at the lake in Rimini, SC
A bedroom with a bed, a chair, a TV, a ceiling fan, and a painting on the wall.

13. Country Resting Spot just off I95. 12 miles west on hwy 6.

Country Resting Spot just off I95. 12 miles west on hwy 6.
Elloree
9.4 out of 10, Exceptional, (25 reviews)
"Everyone was pleased and said they would stay here again."
United States
Tom B.
The price is ￥16,974
￥24,822 total
includes taxes & fees
Nov 5 - Nov 6
Country Resting Spot just off I95. 12 miles west on hwy 6.
A living room with a sofa, two armchairs, a coffee table, and a lamp.

14. Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
The price is ￥19,736
￥29,268 total
includes taxes & fees
Nov 6 - Nov 7
Modern apartment overlooking historic downtown Elloree, SC.
A wooden deck with a white sofa, a wooden serving tray with snacks, and a pitcher of lemonade.

15. Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (165 reviews)
"Great place to stay on our trip!"
United States
Thomas G.
The price is ￥17,763
￥30,936 total
includes taxes & fees
Nov 9 - Nov 10
Pet friendly country cottage with large fenced-in yard & horses on property
A kitchen with dark blue cabinets, a granite countertop, stainless steel sink, and a microwave.

16. Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Holly Hill
10.0 out of 10, Exceptional, (17 reviews)
"Great stay!"
United States
Hayden S.
The price is ￥19,736
￥24,010 total
includes taxes & fees
Nov 5 - Nov 6
Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
A wooden cabin with a red garage, outdoor seating area, and a deck.

17. Sweet Marion - Dock + Boat Ramp + Hot Tub!

Sweet Marion - Dock + Boat Ramp + Hot Tub!
Summerton
8.8 out of 10, Excellent, (26 reviews)
"Nice comfortable place to stay"
United States
Dylan H.
The price is ￥24,576
￥88,662 total
includes taxes & fees
Nov 8 - Nov 9
Sweet Marion - Dock + Boat Ramp + Hot Tub!
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a gas stove.

18. Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.2 out of 10, Wonderful, (5 reviews)
"A great home and very peaceful!! The host is very friendly and very easy to work with. I recommend this home for a stay 100 percent!!We plan on staying there again when we are in the area, such a great value!!"
United States
Troy K.
The price is ￥23,447
￥42,327 total
includes taxes & fees
Nov 5 - Nov 6
Beautiful brick home w/ large porch and 3 bedrooms
Living area

19. Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Summerton
10.0 out of 10, Exceptional, (2 reviews)
"Nice and private. Very quiet and relaxing. Nice to just sit on the front porch with the sunrise."
United States
Bryant T.
The price is ￥34,736
￥79,918 total
includes taxes & fees
Nov 30 - Dec 1
Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
A living room with a beige sofa, a patterned armchair, a coffee table, and a blue door with a stained glass window.

20. Turtle Cove - Lake Living on Lake Marion

Turtle Cove - Lake Living on Lake Marion
Summerton
10.0 out of 10, Exceptional, (1 review)
"Great quiet and cozy home with a nice backyard and porch with the easy water access by dock. Really enjoyed our stay."
United States
Judith H.
The price is ￥25,551
￥79,066 total
includes taxes & fees
Nov 5 - Nov 6
Turtle Cove - Lake Living on Lake Marion
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santee Hotel Reviews

SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

10/10 Excellent
"Nice new mattress, comfy bed... decent bathroom with nice products... clean and very affordable"
Tina 1-night trip
Posted 9 hours ago
SureStay Hotel by Best Western Manning

Find out more about Santee

Search for holiday rentals in Santee on Expedia! You can easily find your home rentals, villas, holiday apartments in Santee using one of the methods below:

  • View our selection of featured holiday rentals in Santee
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Look no further and take a look at our great range of rental properties in Santee!

Frequently asked questions

Can I find vacation rentals in Santee?

Yes, we offer vacation rentals near the most popular points of interest in Santee, or you can select a more remote option if you'd like a relaxing place to stay. Tourists appreciate the top-notch restaurants and coffeehouses in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best vacation home rentals in Santee?

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: This highly rated vacation home rental in Santee is located on a lake and has a patio, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals are there in Santee?

Expedia has 9 vacation rentals for your stay in Santee.

What can I see and do in Santee?

While you're exploring the area, Lake Marion and Taw Caw Creek Park are a couple of picturesque spots to get outside and enjoy nature. Santee Cooper Country Club and Santee State Park are other places to visit while you're in town.

What are vacation rentals like in Santee?

Vacation rentals are private accommodations you can book for several days or more in Santee. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for family gatherings.