Find hotels in Santa Maria, Guayaquil

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Jan 30 - Jan 31
Tomorrow
Jan 31 - Feb 1
This weekend
Jan 30 - Feb 1
Next weekend
Feb 6 - Feb 8

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Maria hotels

Outdoor spa tub

Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana, 7.5 km from Santa Maria
9.4 out of 10, Exceptional, (104 reviews)
"The property was very clean and well maintained. Lots of security. The building is on the riverfront with many excellent restaurants within a few steps. Vibrant night life which was unfortunately very noisy when trying to sleep. Within walking distance to many attractions."
United States
Carolyn
The price is ￥15,989
￥16,142 total
Feb 12 - Feb 13
Luxury Suites Riverfront GYE
Rooftop terrace

River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana, 7.6 km from Santa Maria
8.8 out of 10, Excellent, (46 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ￥12,267
￥12,420 total
Feb 1 - Feb 2
River View suites Puerto Santa Ana gye
Lobby lounge

Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 7.8 km from Santa Maria
8.8 out of 10, Excellent, (136 reviews)
"Breakfast was good. I enjoyed my scrambled eggs and toast "
United States
Caitlin
The price is ￥9,097
￥10,160 total
Feb 1 - Feb 2
Mansión del Río
Reception

Hostal California Inn

Hostal California Inn
3.0 star property
7.4 km from Santa Maria
8.6 out of 10, Excellent, (8 reviews)
"Me encantó, es muy cómoda, la habitación super amplia y limpia Si duda volveré "
Mexico
Anita
Hostal California Inn
Exterior

Hotel La Ria Durán

Hotel La Ria Durán
3.0 star property
9.8 km from Santa Maria
7.4 out of 10, Good, (20 reviews)
"Muy buena experiencia"
Ecuador
HERNAN
The price is ￥7,351
￥7,351 total
Feb 1 - Feb 2
Hotel La Ria Durán
2 bars/lounges, lobby lounge

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana, 7.5 km from Santa Maria
9.2 out of 10, Wonderful, (1,000 reviews)
"Clean rooms,great staff and very good food"
Canada
Abel Patricio
The price is ￥15,300
￥17,213 total
Feb 17 - Feb 18
Wyndham Guayaquil Puerto Santa Ana
Comfort Apartment, Kitchenette

Guayacan Apart Hotel

Guayacan Apart Hotel
2.0 star property
Downtown Guayaquil, 7.6 km from Santa Maria
The price is ￥6,126
￥6,126 total
Feb 1 - Feb 2
Guayacan Apart Hotel
Interior

Murali Hostal Guayaquil

Murali Hostal Guayaquil
3.0 star property
Simón Bolívar, 5.2 km from Santa Maria
7.0 out of 10, Good, (41 reviews)
"The hotel was clean. I never figured out the hot water, so took cold shower. Don't know if there wasn't any hot water or I didn't wait long enough for it to be hot. Hotel staff not very friendly. Breakfast was scrambled egg w/ white toast and coffee. Milk for coffee was curdled. We paid $66. The hotel didn't have our reservation, so I was glad to have reservation printed out from internet. The cost of rooms at the desk was slightly higher. It was not worth the $66.00 paid, but it was not...
United States
Anonymous traveler
Murali Hostal Guayaquil
Daily buffet breakfast (USD 19 per person)

Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel
5.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (617 reviews)
"Very nice place to stay ! "
United States
Diana
The price is ￥13,784
￥15,545 total
Feb 1 - Feb 2
Sheraton Guayaquil Hotel
Property grounds

Hostal Macaw

Hostal Macaw
3.0 star property
Kennedy, 4.6 km from Santa Maria
10.0 out of 10, Exceptional, (9 reviews)
"Wonderful hosts and felt like home "
United States
Tina
The price is ￥10,699
￥10,852 total
Feb 1 - Feb 2
Hostal Macaw
Terrace/patio

Hotel del Parque

Hotel del Parque
4.5 star property
7 km from Santa Maria
9.8 out of 10, Exceptional, (109 reviews)
"Friendly staff. We arrived very early and they were ablemto accommodate an early check-in. The hotel is beautiful "
Canada
Victor
The price is ￥48,547
￥53,402 total
Feb 6 - Feb 7
Hotel del Parque
Economy Double Room | In-room safe, free WiFi

Malecon Guesthouse

Malecon Guesthouse
3.0 star property
River City, 7.9 km from Santa Maria
The price is ￥2,144
￥3,829 total
Feb 1 - Feb 2
Malecon Guesthouse
Executive Suite, Kitchenette, City View | Private kitchen | Microwave, electric kettle, griddle, cookware/dishes/utensils

Suitesecu Rentals Guayaquil

Suitesecu Rentals Guayaquil
4.5 star property
Garzota, 5.1 km from Santa Maria
9.0 out of 10, Wonderful, (10 reviews)
"You can walk to the airport."
United States
Digna
Suitesecu Rentals Guayaquil
Reception

TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.0 out of 10, Wonderful, (1,001 reviews)
"Excellent location, service, room and property. "
United States
Angela
The price is ￥12,252
￥13,860 total
Feb 1 - Feb 2
TRYP by Wyndham Guayaquil Airport
Children's activities

Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 6.9 km from Santa Maria
9.4 out of 10, Exceptional, (1,003 reviews)
"Nice hotel with great breakfast and dining"
United States
Eulalia
The price is ￥12,252
￥13,860 total
Feb 1 - Feb 2
Oro Verde Guayaquil
Indoor pool, open 8:00 AM to 10 PM, sun loungers

Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 7.9 km from Santa Maria
8.0 out of 10, Very Good, (389 reviews)
"Great customer service, very kind staff, amazing location"
Canada
Maria Lorena
Hotel Ramada
Restaurant

Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 7.9 km from Santa Maria
10.0 out of 10, Exceptional, (3 reviews)
"The staff was very friendly and helpful. The hotel is new and modern, it is a good place to relax and work. "
United States
Richard
The price is ￥59,728
￥66,352 total
Feb 3 - Feb 4
Hotel Río Guayas by Art Hotels Ecuador
Junior Suite, 1 Double Bed, Kitchenette | Premium bedding, free WiFi, bed sheets

San Francisco Apart Hotel

San Francisco Apart Hotel
3.0 star property
La Atarazana, 6 km from Santa Maria
6.2 out of 10, (23 reviews)
"Receptionist was very helpful finding us delivery food on arrival."
United States
William
The price is ￥5,225
￥5,378 total
Feb 1 - Feb 2
San Francisco Apart Hotel
Ecotours

Fortune Hotel

Fortune Hotel
3.0 star property
River City, 7.7 km from Santa Maria
8.0 out of 10, Very Good, (7 reviews)
"Very bad Hotel. Not using Expedia again. "
United States
Bryan
The price is ￥7,581
￥7,734 total
Feb 1 - Feb 2
Fortune Hotel
Deluxe Loft | Living area | 65-inch LCD TV with digital channels, Netflix, heated floors

PRAGA APARTMENTS

PRAGA APARTMENTS
4.0 star property
Urdesa, 4.2 km from Santa Maria
9.0 out of 10, Wonderful, (15 reviews)
"Great place to stay at "
United States
Eric
PRAGA APARTMENTS
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like San Francisco Square and Central Market while you're in town.

Puerto Santa Ana

Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and Numa Pompilio Llona Street while you're exploring Puerto Santa Ana and the surrounding neighborhoods.

Bolívar

While Bolívar isn't home to many top sights, Malecon Mall and Civic Center are some notable places to visit nearby.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

Top Santa Maria Hotel Reviews

Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

10/10 Excellent
"Clean walking distance from airport. Great staff, good food "
Jacob 1-night trip
Posted 2 days ago
Holiday Inn Guayaquil Airport by IHG

Frequently asked questions

What is Santa Maria like?
Travelers are sure to enjoy a stay in Guayaquil's Santa Maria neighborhood.
If I need to cancel my hotel reservation in Santa Maria, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then filter by "fully refundable" to get the best options available in Santa Maria.
Where can I learn more about changing or cancelling my trip to Santa Maria?
For more information about changing or cancelling your trip to Santa Maria, go to https://www.expedia.com/service/.
What can I see and do in this Guayaquil neighborhood?
Salón de Eventos Rubi, City Mall, and Guayaquil Parrot are just a few of the places to visit in and around Santa Maria. La Rotonda Shopping Center and Santa Ana Port are also worth a visit when you're out sightseeing in Guayaquil.