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Oct 30 - Nov 1
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Nov 6 - Nov 8

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Our top choices for Santa Maria hotels

A hot tub surrounded by palm trees and a brick wall, with a metal railing in the foreground.

1. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 4.8 km from Santa Maria
9.2 out of 10, Wonderful, (1,001 reviews)
"Best hotel and great location food amazing"
United States
Giselle
The price is ￥12,053
￥13,495 total
Nov 6 - Nov 7
Wyndham Garden Guayaquil
A person sitting by a window with a towel on their head, reading a magazine.

2. Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
5.5 km from Santa Maria
9.6 out of 10, Exceptional, (1,000 reviews)
"As close to the airport as you would want to be. No noise, and the pool and hot tube is great after a long travel time."
United States
Frederick
The price is ￥15,914
￥17,899 total
Nov 27 - Nov 28
Holiday Inn Guayaquil Airport by IHG
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

3. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 4.9 km from Santa Maria
9.0 out of 10, Wonderful, (1,001 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ￥12,613
￥14,111 total
Nov 1 - Nov 2
Courtyard by Marriott Guayaquil
A reception desk with a marble top and a modern light fixture above it.

4. TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 4.9 km from Santa Maria
9.0 out of 10, Wonderful, (1,001 reviews)
"Convenient near airport."
United States
MIGUEL A.
The price is ￥14,189
￥16,002 total
Nov 15 - Nov 16
TRYP by Wyndham Guayaquil Airport
A high-rise hotel interior with multiple floors, large windows, and modern lighting fixtures.

5. Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 4.2 km from Santa Maria
8.8 out of 10, Excellent, (1,000 reviews)
"I made the reservation 30 minutes before my arrival through a 3rd party and everything went smoothly. Room was clean and The staff was very professional."
United States
Eduardo
The price is ￥15,411
￥17,346 total
Nov 22 - Nov 23
Hilton Colon Guayaquil
A modern living room with a sectional sofa, a yellow armchair, and a wooden coffee table.

6. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 4.9 km from Santa Maria
9.2 out of 10, Wonderful, (756 reviews)
"Very helpful and accommodating airport shuttle service."
United States
Jerry
The price is ￥13,401
￥15,135 total
Nov 2 - Nov 3
Radisson Hotel Guayaquil
An outdoor seating area with wicker chairs and a table, a glass wall with a reflection, and hanging orange lights.

7. Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport
4.0 star property
Garzota, 4.9 km from Santa Maria
8.6 out of 10, Excellent, (291 reviews)
"The staff was very nice and helpful, the room was very clean along with their good smelling towels. Area seemed very safe."
United States
Diana
The price is ￥9,474
￥10,658 total
Nov 1 - Nov 2
Hotel Puerto Pacifico Guayaquil Airport
An outdoor patio with wicker furniture, a stone wall, and a water feature.

8. Hotel Marcelius

Hotel Marcelius
3.5 star property
Kennedy, 4.7 km from Santa Maria
8.4 out of 10, Very good, (265 reviews)
"Clean, comfortable room, quite, nice staff. Parking lot small, limited and uncomfortable"
Canada
Filippo
The price is ￥9,222
￥10,405 total
Nov 13 - Nov 14
Hotel Marcelius
A rooftop pool with lounge chairs and umbrellas, surrounded by greenery and a multi-level parking garage in the background.

9. Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel
5.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (694 reviews)
"Clean room, nice hotel"
United States
John
The price is ￥15,252
￥17,171 total
Nov 27 - Nov 28
Sheraton Guayaquil Hotel
Property entrance

10. DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 5.2 km from Santa Maria
9.0 out of 10, Wonderful, (675 reviews)
"Clean room, staff was nice, air conditioning was really nice to have"
Canada
Estéban
The price is ￥5,676
￥5,834 total
Nov 1 - Nov 2
DC Suites Aeropuerto
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

11. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 6.9 km from Santa Maria
9.6 out of 10, Exceptional, (1,001 reviews)
"Very friendly staff, excellent breakfast, maintained and modern rooms. Was a great stay."
United States
ricardo
The price is ￥14,032
￥15,829 total
Nov 1 - Nov 2
Oro Verde Guayaquil
An indoor swimming pool with a tiled edge, surrounded by lounge chairs and a seating area with tables and chairs.

12. Cedros Inn Boutique Hotel

Cedros Inn Boutique Hotel
3.5 star property
Urdesa, 4.6 km from Santa Maria
8.6 out of 10, Excellent, (96 reviews)
"Staff was very helpful and nice. The property was well kept, and well located"
United States
Jazmin
The price is ￥10,008
￥11,167 total
Nov 1 - Nov 2
Cedros Inn Boutique Hotel
A building with a traditional architectural style, featuring a prominent entrance with a set of stairs leading up to a double door.

13. Luxva Hotel Boutique

Luxva Hotel Boutique
3.0 star property
Urdesa, 4.7 km from Santa Maria
9.4 out of 10, Exceptional, (184 reviews)
"Love the breakfast menu and security."
United States
Marcela
The price is ￥10,294
￥10,452 total
Nov 1 - Nov 2
Luxva Hotel Boutique
A modern living room with a large window, a flat-screen TV, a sofa, and a coffee table.

14. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana, 7.5 km from Santa Maria
9.4 out of 10, Exceptional, (1,003 reviews)
"Love staying at this hotel!"
United States
Isabel
The price is ￥17,311
￥19,436 total
Nov 29 - Nov 30
Wyndham Guayaquil Puerto Santa Ana
A spacious indoor area with multiple seating arrangements, including sofas and chairs, surrounded by potted plants.

15. MundialCity Hotel Guayaquil

MundialCity Hotel Guayaquil
3.0 star property
Simón Bolívar, 5.1 km from Santa Maria
8.4 out of 10, Very good, (175 reviews)
"Nice place, good price, close to the airport..always stay there the night before a flight."
United States
John
The price is ￥6,768
￥6,926 total
Nov 13 - Nov 14
MundialCity Hotel Guayaquil
A modern hotel with a white facade, large glass windows, and a green sign indicating it's a McCutes hotel.

16. MC Suites

MC Suites
3.5 star property
Kennedy, 4.4 km from Santa Maria
8.4 out of 10, Very good, (145 reviews)
"Staff is great and they are pending that you enjoy time in the hotel!"
United States
Sofia
The price is ￥10,216
￥10,374 total
Nov 1 - Nov 2
MC Suites
A rooftop terrace with outdoor seating, a bar area, and potted plants.

17. Harmonie

Harmonie
2.0 star property
Simón Bolívar, 4.8 km from Santa Maria
9.0 out of 10, Wonderful, (110 reviews)
"Clean room nice staff shopping malls near by business is friendly recommend 100%"
United States
Angie
The price is ￥6,811
￥6,811 total
Nov 21 - Nov 22
Harmonie
A pool area with lounge chairs, a waterfall, and tropical plants.

18. Iguanazu Bed & Breakfast

Iguanazu Bed & Breakfast
3.5 star property
3 km from Santa Maria
9.2 out of 10, Wonderful, (49 reviews)
"Breakfasts were excellent. Staff went out of their way to accommodate late arrival. "
Canada
Kimberly
The price is ￥15,953
￥17,706 total
Nov 12 - Nov 13
Iguanazu Bed & Breakfast
A compact kitchen with a stainless steel refrigerator, a built-in oven, and a window with a view of buildings.

19. Suitesecu Rentals Guayaquil

Suitesecu Rentals Guayaquil
4.5 star property
Garzota, 5.1 km from Santa Maria
9.4 out of 10, Exceptional, (23 reviews)
"Great for 1 night in Guayaquil before a morning flight."
Canada
Charles-Olivier
The price is ￥4,131
￥5,155 total
Nov 8 - Nov 9
Suitesecu Rentals Guayaquil
A hotel room with a bed, a green sofa, a dining table with chairs, and a small table with a laptop and a vase.

20. Hotel Air Suites

Hotel Air Suites
2.5 star property
Simón Bolívar, 5.1 km from Santa Maria
7.0 out of 10, Good, (233 reviews)
"Great hospitality and welcoming staff."
United States
Alexander
The price is ￥6,503
￥7,153 total
Nov 1 - Nov 2
Hotel Air Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Santa Maria

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A hot tub surrounded by palm trees and a brick wall, with a metal railing in the foreground.
Wyndham Garden Guayaquil
3.5 star property
9.2
Wonderful
1,001 reviews
View
A person sitting by a window with a towel on their head, reading a magazine.
Holiday Inn Guayaquil Airport by IHG
3.5 star property
9.6
Exceptional
1,000 reviews
View
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.
Courtyard by Marriott Guayaquil
3.5 star property
9.0
Wonderful
1,001 reviews
View
A modern living room with a sectional sofa, a yellow armchair, and a wooden coffee table.
Radisson Hotel Guayaquil
5.0 star property
9.2
Wonderful
756 reviews
View
A reception desk with a marble top and a modern light fixture above it.
TRYP by Wyndham Guayaquil Airport
4.5 star property
9.0
Wonderful
1,001 reviews
View

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A densely packed urban area with numerous buildings and a prominent tower on a hill.

Puerto Santa Ana

Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and Numa Pompilio Llona Street while you're exploring Puerto Santa Ana and the surrounding neighborhoods.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

Top Santa Maria Hotel Reviews

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

8/10 Good
"Todo bien"
Felipe 2-night trip
Posted 4 hours ago
Wyndham Guayaquil Puerto Santa Ana

Frequently asked questions

What is Santa Maria like?
Travelers are sure to enjoy a stay in Guayaquil's Santa Maria neighborhood.
If I need to cancel my hotel reservation in Santa Maria, will I receive a refund?
Yes, the majority of hotel bookings are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then filter by "fully refundable" to get the best options available in Santa Maria.
Where can I learn more about changing or cancelling my trip to Santa Maria?
For more information about changing or cancelling your trip to Santa Maria, go to https://www.expedia.com/service/.
What can I see and do in this Guayaquil neighborhood?
Salón de Eventos Rubi, City Mall, and Guayaquil Parrot are just a few of the places to visit in and around Santa Maria. La Rotonda Shopping Center and Churute Mangroves Ecological Reserve are also worth a visit when you're out sightseeing in Guayaquil.