Find Luxury Hotels in Santa Ana, CA

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Our top choices for Santa Ana luxury hotels

MainStay Suites John Wayne Airport by Choice Hotels

MainStay Suites John Wayne Airport by Choice Hotels
2.5 star property
Santa Ana
8.0 out of 10, Very Good, (1514)
"Great stay"
United States
Ron
The price is ¥13,941
¥15,781 total
includes taxes & fees
Jan 19 - Jan 20, 2026
MainStay Suites John Wayne Airport by Choice Hotels

Best Western Plus Orange County Airport North

Best Western Plus Orange County Airport North
2.5 star property
Santa Ana
8.6 out of 10, Excellent, (1724)
"Everything was clean and Breakfast was great"
United States
Florlyn p
The price is ¥17,049
¥19,265 total
includes taxes & fees
Dec 30 - Dec 31
Best Western Plus Orange County Airport North

Courtyard by Marriott Santa Ana Orange County

Courtyard by Marriott Santa Ana Orange County
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (1001)
"The staff and hotel were fantastic and it was very quiet during my stay"
United States
JAMES
The price is ¥15,360
¥17,386 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Courtyard by Marriott Santa Ana Orange County

La Quinta Inn & Suites by Wyndham Orange County Airport

La Quinta Inn & Suites by Wyndham Orange County Airport
3.0 star property
Santa Ana
7.8 out of 10, Good, (2027)
"My family and I enjoyed our stay. Would book again."
United States
Latausha
The price is ¥16,260
¥18,373 total
includes taxes & fees
Jan 8 - Jan 9, 2026
La Quinta Inn & Suites by Wyndham Orange County Airport

Motel 6 Santa Ana, CA

Motel 6 Santa Ana, CA
2.0 star property
Lyon Street
7.4 out of 10, Good, (1000)
"Staff was nice and room was really clean"
United States
Anelyn
The price is ¥13,308
¥15,508 total
includes taxes & fees
Dec 30 - Dec 31
Motel 6 Santa Ana, CA

City Express by Marriott Santa Ana/Orange County Airport

City Express by Marriott Santa Ana/Orange County Airport
2.5 star property
Santa Ana
7.2 out of 10, Good, (1000)
"O have a great time everything was great thanks I back again "
United States
Silvia
The price is ¥17,473
¥19,779 total
includes taxes & fees
Jan 3 - Jan 4, 2026
City Express by Marriott Santa Ana/Orange County Airport

Courtyard by Marriott Costa Mesa South Coast Metro

Courtyard by Marriott Costa Mesa South Coast Metro
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (1004)
"Ths stay was very nice. Staff super helpful. Breakfast had many choices"
United States
Wendy
The price is ¥20,667
¥23,465 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Courtyard by Marriott Costa Mesa South Coast Metro

Embassy Suites by Hilton Santa Ana Orange County Airport

Embassy Suites by Hilton Santa Ana Orange County Airport
3.5 star property
Santa Ana
6.2 out of 10, (1827)
"The hotel was very clean and the staff was super friendly. "
United States
Steven
The price is ¥15,920
¥18,021 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Embassy Suites by Hilton Santa Ana Orange County Airport

Red Roof Inn Santa Ana

Red Roof Inn Santa Ana
2.0 star property
Santa Ana
6.8 out of 10, (1003)
"Good stay for a night or two"
United States
Jared
The price is ¥14,090
¥15,949 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Red Roof Inn Santa Ana

Hotel Zessa Orange County Airport, a DoubleTree by Hilton

Hotel Zessa Orange County Airport, a DoubleTree by Hilton
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (579)
"Great property in great location. "
United States
Stanislav
The price is ¥19,130
¥21,617 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hotel Zessa Orange County Airport, a DoubleTree by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Santa Ana

Santa Anaand its attractions for luxury travelers

Santa Ana, California, offers a captivating blend of culture and luxury that travelers will appreciate. Start your exploration at the Bowers Museum, where exquisite exhibits showcase Native American art and California history, providing a rich cultural backdrop to your stay. For art enthusiasts, the nearby Orange County Museum of Art features contemporary works that will spark inspiration and conversation. Enjoy a leisurely afternoon at the serene Centennial Park, perfect for a family picnic or a tranquil stroll amidst lush landscapes. If you're seeking shopping and dining, the South Coast Plaza is a must-visit, high-end retailers like Chanel and Gucci, alongside gourmet dining options that will satisfy your culinary cravings. Finally, indulge in a performance at the Segerstrom Center for the Arts, where world-class theatre and music events await. For a luxurious stay, consider the hotels in the South Coast area, where you can enjoy opulent amenities, attentive service, and easy access to these attractions—all while feeling pampered in a vibrant atmosphere.

Find the best luxury hotels and resorts in Santa Ana

For travelers seeking an upscale experience in Santa Ana, California, these luxury hotels provide exceptional amenities and service that cater to travelers.

Hotel Zessa Orange County Airport, a DoubleTree by Hilton

  • Why it's great for a luxury retreat: Hotel Zessa Orange County Airport is an excellent choice for luxury seekers, a popular guest review rating of 8.2. This elegant hotel features designer toiletries and premium bedding, ensuring a plush stay for guests. The on-site concierge is available to assist with arrangements, enhancing the overall experience with personalized service and local insights.
  • Other amenities: Guests can enjoy a relaxing outdoor pool and hot tub, perfect for unwinding after a day of travel. The hotel is conveniently located within a shopping district, allowing guests to indulge in retail therapy right at their doorstep. Additional features include contactless check-in for a seamless arrival experience, accessible parking options, and daily housekeeping to maintain comfort. For those needing to stay connected, the hotel offers fitness facilities nearby and complimentary toiletries to elevate the luxury experience.
  • Nearby attractions: South Coast Plaza - 1.98 miles, Segerstrom Center for the Arts - 1.8 miles, The Observatory - 3.24 miles

Top Santa Ana Hotel Reviews

Frequently asked questions

Are you searching for a great accommodation for your luxury holiday in Santa Ana?
Use Expedia to arrange your flight to John Wayne Airport (SNA) airport or Fullerton, CA (FUL-Fullerton Municipal) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you need to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Santa Ana has to offer. During your visit, you might want to enjoy the beaches and shopping which Santa Ana is known for.
When can I expect good weather in Santa Ana?
Planning for the weather is an important factor for making your trip to Santa Ana a success, especially when you're splurging. The hottest months are usually August and September with an average temp of 74°F, while the coldest months are February and January with an average of 58°F. Average annual precipitation for Santa Ana is 12 inches.
What's there to see and do in Santa Ana?
Take in some sights and attractions while you're in Santa Ana by visiting Old Orange County Courthouse, Bowers Museum, and Santa Ana Zoo. If you have a little extra time during your trip, you might want to make a stop at Discovery Science Center and The Observatory.
How can I get around Santa Ana?
It's easier to get around town in style when you know your options. To see more of the larger area, hop aboard a train at Santa Ana Regional Transportation Center.

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