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Our top choices for San Francisco hotels

Hotel Gran David

Hotel Gran David
3.5 star property
Santiago
8.6 out of 10, Excellent, (375 reviews)
"Clean and pleasant. The restaurant has an excellent menu."
United States
Brenda
Hotel Gran David

HOTEL VISTA LAGO

HOTEL VISTA LAGO
3.0 star property
La Pena
9.4 out of 10, Exceptional, (95 reviews)
"Great atmosphere around the restaurant and pool. We found it very relaxing in an otherwise busy city. Restaurant makes good meals and the service is great."
Canada
Conrad
The price is ¥11,830
¥13,013 total
includes taxes & fees
Feb 26 - Feb 27
HOTEL VISTA LAGO

Hotel Mykonos Panama

Hotel Mykonos Panama
3.5 star property
Nuevo Santiago
8.8 out of 10, Excellent, (552 reviews)
"Everything was nice room, staff, amenities!"
United States
Daniel
The price is ¥13,918
¥15,310 total
includes taxes & fees
Feb 26 - Feb 27
Hotel Mykonos Panama

Hotel Galería

Hotel Galería
3.0 star property
Nuevo Santiago
8.4 out of 10, Very Good, (208 reviews)
"Everything was nice!"
United States
Daniel
The price is ¥10,647
¥11,712 total
includes taxes & fees
Feb 26 - Feb 27
Hotel Galería

Hotel Anachoreo

Hotel Anachoreo
3.0 star property
Santa Fe
9.6 out of 10, Exceptional, (38 reviews)
"Wonderful place at a beautiful stay . I can recommend it totally ! "
United States
Ingmar
Hotel Anachoreo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

What's the best place for a stay in San Francisco?
Hotel Mykonos Panama, located 10.4 mi (16.8 km) from the heart of San Francisco, is a top choice for your stay based on our traveler data. Other good options for your trip to the area are Hotel Gran David and HOTEL VISTA LAGO. See all available top hotels, or vacation rentals in San Francisco.
What are some of the best vacation rentals that San Francisco has to offer?
Cabana Vergara Santa Fe: This vacation home rental outside of San Francisco offers a patio, a garden, and air-conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a coffee maker. See all vacation rentals in San Francisco.
If I need to cancel my hotel reservation in San Francisco, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in San Francisco.
Where can I learn more about changing or cancelling my trip to San Francisco?
To find more details about picking new dates or cancelling your trip to San Francisco, click here.
What is staying in San Francisco like?
Visitors to San Francisco are sure to find plenty to explore and enjoy. There are 17 hotels and other accommodations in the surrounding area. Find out more about San Francisco.
What should I see while I'm in San Francisco?
Places to visit in the wider area include Laguna de La Yeguada, Parque Acuatico Italia Guadalupe Panama, and Catedral of Santiago Apostol. You'll also find Los Pozos Termales and Omar Torrijos Herrera Stadium in the area. Check out what more to see and do in Expedia's San Francisco guide.
What's the weather like in San Francisco?
The hottest months are usually March and April with an average temp of 80°F, while the coldest months are January and December with an average of 77°F. The rainiest months in San Francisco are October, August, June, and November, with each month seeing an average of 18 inches of rainfall.