A densely packed urban area with numerous buildings and a prominent tower on a hill.

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Oct 2 - Oct 4
In two weeks
Oct 9 - Oct 11

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Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,007 reviews)
"Great hotel to stay in! Staff was super friendly!"
United States
Isabel
The price is ￥17,364
￥19,494 total
Oct 11 - Oct 12
Wyndham Guayaquil Puerto Santa Ana
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

2. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (65 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ￥16,844
￥17,001 total
Sep 28 - Sep 29
River View suites Puerto Santa Ana gye
A cocktail on a marble table with a pool in the background.

3. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (165 reviews)
"The pool was enjoyable but going during the day so the water isn’t as cold."
United States
Julio
The price is ￥6,969
￥7,126 total
Sep 28 - Sep 29
Hotel Patrimonial by Greenfield
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

4. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (147 reviews)
"Great place historical. Good service n breakfast. Great location"
United States
Mary Grant
The price is ￥9,062
￥10,153 total
Oct 27 - Oct 28
Mansión del Río
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

5. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (413 reviews)
"👍"
United States
Washington
The price is ￥9,909
￥10,066 total
Sep 28 - Sep 29
Hotel Ramada
A hotel room with a bed, a nightstand, a desk, a chair, and a window with curtains.

6. Hotel Las Peñas

Hotel Las Peñas
3.0 star property
Rocafuerte, 1.8 km from Puerto Santa Ana
8.4 out of 10, Very good, (124 reviews)
"Great location, kind staff, would recommend"
United States
Melida
The price is ￥3,694
￥3,851 total
Oct 1 - Oct 2
Hotel Las Peñas
An aerial view of a hotel with a swimming pool surrounded by lush greenery and a decorative garden.

7. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,011 reviews)
"Nice breakfast setup the pool was fantastic and the room very spacious location was perfect next to everything"
United States
Edwin
The price is ￥12,003
￥13,439 total
Oct 26 - Oct 27
Grand Hotel Guayaquil, Centro Histórico.

8. DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 3 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (661 reviews)
"The hotel was very nice and a very helpful staff. Easy on the eyes too."
Canada
Jeff
The price is ￥5,662
￥5,819 total
Sep 28 - Sep 29
DC Suites Aeropuerto
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

9. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (956 reviews)
"There’s a restaurant downstairs. Try the Encocado de camarón. Best food ever!"
United States
Marlaynna
The price is ￥10,179
￥11,433 total
Oct 4 - Oct 5
Hotel Palace Guayaquil
An outdoor cafe with tables and chairs, surrounded by trees and buildings.

10. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
7.6 out of 10, Good, (10 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is ￥7,785
￥7,942 total
Sep 28 - Sep 29
Fortune Hotel
A buffet setup with various food items, a modern chandelier, and a patterned floor.

11. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (341 reviews)
"Clean, safe & secure facilities with friendly and accommodating staff. Rooms were decent size/layout, with very comfortable bedding, The food at the hotel is a little pricey but excellent, as is the location - steps away from other outstanding local restaurants."
United States
Carmen
The price is ￥9,909
￥11,136 total
Oct 2 - Oct 3
Ibis Styles El Malecon Guayaquil
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

12. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,002 reviews)
"Great Location!"
United States
Gustavo
The price is ￥14,470
￥16,310 total
Oct 4 - Oct 5
Oro Verde Guayaquil
A hotel room with two beds, a TV, a painting, and a desk.

13. Hotel GH Alexander

Hotel GH Alexander
3.5 star property
Rocafuerte, 2.1 km from Puerto Santa Ana
8.8 out of 10, Excellent, (49 reviews)
"Breakfast was amazing! I loved everything about it!"
United States
Josue
The price is ￥4,316
￥4,473 total
Oct 13 - Oct 14
Hotel GH Alexander
A hotel with a modern facade, featuring a prominent vertical light installation.

14. Hotel Sada

Hotel Sada
3.0 star property
1.5 km from Puerto Santa Ana
9.8 out of 10, Exceptional, (12 reviews)
"Habitación limpia, personal amable, y desayuno fresco. "
Mexico
Ligia
The price is ￥6,710
￥6,867 total
Oct 28 - Oct 29
Hotel Sada
A neatly made bed with a heart-shaped arrangement of red roses, a champagne bucket, and two wine glasses on a tray.

15. San Francisco Apart Hotel

San Francisco Apart Hotel
3.0 star property
La Atarazana, 1.4 km from Puerto Santa Ana
6.4 out of 10, (25 reviews)
"Nice place, nice amenities, nice staff, we'll back! "
United States
Giovanny
The price is ￥5,505
￥5,662 total
Sep 28 - Sep 29
San Francisco Apart Hotel
A modern hotel room with a bed, bedside table, and a desk with a chair.

16. Hotel Varadero Internacional

Hotel Varadero Internacional
3.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
8.2 out of 10, Very good, (83 reviews)
"Overall a good place to stay and close to most destinations."
United States
Daniel
The price is ￥3,964
￥4,121 total
Sep 28 - Sep 29
Hotel Varadero Internacional
A couple in bed with a tray of breakfast including toast, fruit, and juice.

17. The Park Hotel

The Park Hotel
2.5 star property
Rocafuerte, 2 km from Puerto Santa Ana
8.4 out of 10, Very good, (44 reviews)
"I really enjoyed the location of the property and friendliness of the staff!"
Canada
Isaiah
The price is ￥8,007
￥8,808 total
Oct 26 - Oct 27
The Park Hotel
A modern lobby with large windows, a staircase, and comfortable seating areas.

18. Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil
5.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (128 reviews)
"Good staff...great location"
United States
ALBERTO
The price is ￥12,031
￥15,382 total
Oct 4 - Oct 5
Doubletree By Hilton Guayaquil
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

19. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ￥52,846
￥58,799 total
Oct 9 - Oct 10
Hotel Río Guayas by Art Hotels Ecuador
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

20. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,000 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ￥12,582
￥14,076 total
Oct 3 - Oct 4
Courtyard by Marriott Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A densely packed hillside cityscape with colorful buildings and a prominent tower against a sunset sky.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to Alban Borja Commercial Center or San Marino Mall.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

Top Puerto Santa Ana Hotel Reviews

Wyndham Garden Guayaquil

Wyndham Garden Guayaquil

10/10 Excellent
"Excelente desayuno"
Beatriz 1-night trip
Posted 3 hours ago
Wyndham Garden Guayaquil

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 89 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.