A densely packed urban area with numerous buildings and a prominent tower on a hill.

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Check prices for these dates

Next weekend
Jul 3 - Jul 5
In two weeks
Jul 10 - Jul 12

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Our top choices for Puerto Santa Ana hotels

2 bars/lounges, lobby lounge

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Airport transfer and breakfast were great!"
United States
Halima
The price is ￥14,557
￥16,417 total
Jul 12 - Jul 13
Wyndham Guayaquil Puerto Santa Ana
Rooftop terrace

River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (56 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ￥11,531
￥11,693 total
Jun 29 - Jun 30
River View suites Puerto Santa Ana gye
Outdoor spa tub

Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (107 reviews)
"Lots of restaurants nearby"
Canada
kevin
The price is ￥12,778
￥12,940 total
Jun 29 - Jun 30
Luxury Suites Riverfront GYE
Outdoor pool, sun loungers

Iguanazu Bed & Breakfast

Iguanazu Bed & Breakfast
3.5 star property
5.4 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (48 reviews)
"Breakfasts were excellent. Staff went out of their way to accommodate late arrival. "
Canada
Kimberly
The price is ￥18,196
￥20,178 total
Jun 28 - Jun 29
Iguanazu Bed & Breakfast
Living area

NP Hotel & Suites

NP Hotel & Suites
3.0 star property
9.7 km from Puerto Santa Ana
2.0 out of 10, (1 review)
"Deben haber un mejor desayuno, al menos frutas. No es tan bueno como parecía"
United States
Damariz
The price is ￥7,420
￥7,582 total
Jul 5 - Jul 6
NP Hotel & Suites
Terrace/patio

Hotel del Parque

Hotel del Parque
4.5 star property
3.6 km from Puerto Santa Ana
9.8 out of 10, Exceptional, (120 reviews)
"Breakfast excellent"
United States
Priscilla
The price is ￥46,452
￥51,097 total
Jul 5 - Jul 6
Hotel del Parque
Cafe

Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
3.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (1,001 reviews)
"Great place"
Canada
Michael
The price is ￥15,527
￥17,484 total
Jul 11 - Jul 12
Holiday Inn Guayaquil Airport by IHG
Lobby

Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil
5.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (103 reviews)
"Nice business hotel for staying when working abroad"
United States
wagner
The price is ￥12,810
￥14,899 total
Jul 12 - Jul 13
Doubletree By Hilton Guayaquil
Children's activities

Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,004 reviews)
"Great place to stay"
United States
Daniel
The price is ￥13,748
￥15,527 total
Jun 28 - Jun 29
Oro Verde Guayaquil
Lobby

Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 3.2 km from Puerto Santa Ana
8.8 out of 10, Excellent, (932 reviews)
"Excellent stay highly recommended"
United States
Carol
The price is ￥16,578
￥18,640 total
Jul 4 - Jul 5
Hilton Colon Guayaquil
Daily buffet breakfast for a fee

Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel
5.0 star property
Simón Bolívar, 2.9 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (661 reviews)
"Very nice place to stay ! "
United States
Diana
The price is ￥17,791
￥19,974 total
Jun 28 - Jun 29
Sheraton Guayaquil Hotel
Reception

TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,000 reviews)
"Great place to stay, connected to Large Mall with multiple food venue's"
United States
Francis
The price is ￥12,955
￥14,655 total
Jul 12 - Jul 13
TRYP by Wyndham Guayaquil Airport
Terrace/patio

Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport
4.0 star property
Garzota, 3.7 km from Puerto Santa Ana
8.6 out of 10, Excellent, (269 reviews)
"Very clean and comfortable rooms. The staff was very friendly and they're all fluent in English and Spanish. Breakfast in the restaurant was also delicious."
United States
Myna-Maria
The price is ￥9,976
￥11,217 total
Jul 5 - Jul 6
Hotel Puerto Pacifico Guayaquil Airport
Rooftop bar, alfresco dining, open daily

Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,004 reviews)
"The room was really clean and the staff in the lobby were really helpful. Breakfast was good"
United States
Rosa
The price is ￥12,082
￥13,533 total
Jul 3 - Jul 4
Wyndham Garden Guayaquil
Free minibar, in-room safe, soundproofing, iron/ironing board

Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (3 reviews)
"The staff was very friendly and helpful. The hotel is new and modern, it is a good place to relax and work. "
United States
Richard
The price is ￥63,079
￥70,074 total
Jun 29 - Jun 30
Hotel Río Guayas by Art Hotels Ecuador
Lobby lounge

Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (139 reviews)
"Breakfast was good. I enjoyed my scrambled eggs and toast "
United States
Caitlin
The price is ￥9,607
￥10,729 total
Jul 2 - Jul 3
Mansión del Río
Front of property

Luxva Hotel Boutique

Luxva Hotel Boutique
3.0 star property
Urdesa, 3.5 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (181 reviews)
"Love the breakfast menu and security."
United States
Marcela
The price is ￥15,576
￥15,738 total
Jun 28 - Jun 29
Luxva Hotel Boutique
Property entrance

Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (700 reviews)
"Good hotel"
United States
juan pablo
The price is ￥13,748
￥15,527 total
Jun 28 - Jun 29
Radisson Hotel Guayaquil
Lobby

Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,001 reviews)
"Great location!"
United States
Laura
The price is ￥12,939
￥14,476 total
Jul 4 - Jul 5
Courtyard by Marriott Guayaquil
Family House, Private Pool | Living area | Flat-screen TV

Casa con Piscina Privada para Familias

Casa con Piscina Privada para Familias
3.0 star property
15.7 km from Puerto Santa Ana
2.0 out of 10, (2 reviews)
"More cleaning, there was rotten garbage and a bad smell emanated"
United States
Isabel
The price is ￥17,302
￥20,537 total
Jun 30 - Jul 1
Casa con Piscina Privada para Familias
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

An iguana on green grass.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and La Rotonda while you're in town.

A cityscape with colorful buildings, a prominent church, and a hill with residential structures.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or Policentro while you're exploring the area.

Garzota

The restaurants and shopping are a few reasons travelers visit Garzota. Though there aren't many top sights in the neighborhood, you can visit Mall del Sol Shopping Center and City Mall, a few notable attractions nearby.

Bolívar

While Bolívar isn't home to many top sights, Malecon Mall and Sports Federation of Guayas are some notable places to visit nearby.

Top Puerto Santa Ana Hotel Reviews

Hilton Colon Guayaquil

Hilton Colon Guayaquil

10/10 Excellent
"We enjoyed our stay here. The property is clean and there are always people around every day maintaining it in some way. The hotel isn’t renovated though. You can tell it used to be really nice and then it just got older with time. We liked the pool a lot. It was nice and big. The breakfast buffet is good, but it’s really really expensive. It’s definitely not worth what they’re charging, however the alternative (Sal y Pimenta) is very bad. Also over priced with less variety. If I were to do it again, I would probably pre-pay for the breakfast with when I reserved the room because that’s the cheaper option. All that said we would stay here again if we visit Guayaquil. The free shuttle to and from the airport was fantastic."
Eva 5-night trip
Posted 1 hour ago
Hilton Colon Guayaquil

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 80 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Botanical Garden are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Santa Ana Hill and Numa Pompilio Llona Street are a couple of additional sights to visit in Guayaquil.