Find Resorts & Hotels with Spas in Panama Canal Zone

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Panama Canal Zone Resorts & Hotels with Spas

Next weekend
In two weeks

Our top choices for Panama Canal Zone hotels with a spa

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino
4.0 star property
Tocumen
8.6 out of 10, Excellent, (1848)
"Better than expected: Location, transportation to and from airport, pool area tropical and comfortable. "
United States
Marty
The price is ¥19,579
¥21,537 total
includes taxes & fees
Dec 30 - Dec 31
Riande Aeropuerto Hotel & Casino

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (644)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is ¥35,111
¥38,623 total
includes taxes & fees
Jan 25 - Jan 26, 2026
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
5.0 star property
Veracruz
8.0 out of 10, Very Good, (1000)
"Great place and location, excellent food choices! "
United States
Francisco
The price is ¥37,063
¥40,770 total
includes taxes & fees
Jan 7 - Jan 8, 2026
The Westin Playa Bonita Panama

SAND DIAMOND HOTEL

SAND DIAMOND HOTEL
3.0 star property
Colon
8.6 out of 10, Excellent, (214)
"Great hotel"
United States
DIANA
The price is ¥18,632
¥20,495 total
includes taxes & fees
Dec 29 - Dec 30
SAND DIAMOND HOTEL

Radisson Colon 2,000 Hotel & Casino

Radisson Colon 2,000 Hotel & Casino
4.0 star property
Barrio Sur
8.2 out of 10, Very Good, (829)
"Check in was very speedy and welcoming . Javier at the front desk was easy to understand and friendly . Room was nice and bed was comfortable ."
United States
SEAN
The price is ¥15,767
¥17,344 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Radisson Colon 2,000 Hotel & Casino

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1003)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is ¥49,946
¥54,940 total
includes taxes & fees
Jan 3 - Jan 4, 2026
JW Marriott Panama

Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (567)
"Amazing hotel , location , staff and amenities . Clean, elegant , great service. "
United States
Nicole
The price is ¥57,226
¥62,949 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Sofitel Legend Casco Viejo, Panama City

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2141)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is ¥16,901
¥18,591 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Plaza Paitilla Inn Hotel

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (996)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is ¥20,996
¥23,096 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Sheraton Grand Panama

Hyatt Regency Panama City

Hyatt Regency Panama City
4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (139)
"Great hotel fair price"
United States
Santiago
The price is ¥24,542
¥26,996 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Hyatt Regency Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Panama Canal Zone

Top Panama Canal Zone attractions for a relaxing vacation

In the Panama Canal Zone, travelers seeking hotels with spas will find a mix of relaxation and adventure. Start your journey at the Miraflores Locks, where you can witness massive ships navigate through the iconic canal; the visitor center offers an immersive experience that highlights the engineering marvel's history. For nature enthusiasts, the Soberanía National Park is a short drive away, featuring lush rainforests and diverse wildlife, perfect for hiking and birdwatching. After an active day, unwind at a luxury spa hotel in the vibrant Albrook area, where you can enjoy treatments that incorporate local ingredients like cacao and coffee. Don't miss the opportunity to explore the Panama Canal Railway, a scenic train ride that offers stunning views of the canal and surrounding landscapes. Finally, indulge in some retail therapy at the Albrook Mall, one of the largest shopping centers in Latin America, where you can find everything from local crafts to high-end brands. Staying in Albrook not only provides convenient access to these attractions but also ensures a pampered experience with attentive service at your hotel, making it a perfect base for your adventures.

Top Panama Canal Zone Hotel Reviews