A large eye sculpture in a park surrounded by trees.

Search Vacation Homes in Northeast Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Nov 13 - Nov 15
In two months
Dec 25 - Dec 27
In three months
Jan 22 - Jan 24
In four months
Feb 19 - Feb 21

Our top choices for Northeast Missouri vacation homes

A modern kitchen with white cabinets, stainless steel appliances, and a wooden floor.

1. Spacious & Modern 2BR Home with Attached Garage

Spacious & Modern 2BR Home with Attached Garage
Quincy
10.0 out of 10, Exceptional, (55 reviews)
"The place was immaculate and beautifully finished. Josh was great to work with, always responded quickly and very attentive. Highly recommend this property!!"
United States
Jeff C.
The price is ￥18,327
￥36,736 total
includes taxes & fees
Nov 16 - Nov 17
Spacious & Modern 2BR Home with Attached Garage
A modern kitchen with stainless steel appliances, a stone accent wall, and a bar area.

2. Aunt Lele's Cozy Cottage

Aunt Lele's Cozy Cottage
Quincy
9.8 out of 10, Exceptional, (47 reviews)
"Perfect place for our family of 5 to enjoy a weekend visiting my wife’s family."
United States
Matt B.
The price is ￥14,219
￥28,813 total
includes taxes & fees
Nov 11 - Nov 12
Aunt Lele's Cozy Cottage
A living room with a brown sofa, a wooden coffee table, a television on a stand, and a bookshelf.

3. Unwind on Vine

Unwind on Vine
Macon
9.6 out of 10, Exceptional, (38 reviews)
"Very clean and comfortable home. Will definitely stay here again."
United States
Russ S.
The price is ￥26,821
￥42,156 total
includes taxes & fees
Nov 28 - Nov 29
Unwind on Vine
A modern kitchen with white cabinets, a stainless steel refrigerator, and a dining area with a wooden table and white chairs.

4. Peaceful, Country Cottage with Open Floor Plan

Peaceful, Country Cottage with Open Floor Plan
Quincy
9.8 out of 10, Exceptional, (227 reviews)
"The cottage was in a quiet location, clean, and with easy access to both Quincy, IL and Hannibal, MO. The property owner was available and easy to contact."
United States
Jodi
The price is ￥20,510
￥38,791 total
includes taxes & fees
Nov 8 - Nov 9
Peaceful, Country Cottage with Open Floor Plan
A room with a brick wall, shelves with plants, a framed painting, and a patterned bench.

5. Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi

Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
Hannibal
9.8 out of 10, Exceptional, (71 reviews)
"Very nice experience, and close to all the historical sites!"
United States
Steve G.
The price is ￥17,537
￥29,407 total
includes taxes & fees
Nov 9 - Nov 10
Historic brick 2-bedroom house in downtown Hannibal with off street parking WiFi
A spacious living area with a leather sofa, a cowhide rug, and a staircase leading to an upper level.

6. Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat

Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat
Bourbon
10.0 out of 10, Exceptional, (4 reviews)
"Very charming lil cabin! It was perfect for a solo trip. I’d love to come back with my husband for a romantic weekend getaway."
United States
Wendy L.
The price is ￥18,891
￥56,886 total
includes taxes & fees
Nov 1 - Nov 2
Unique Tiny Home! Lakefront ~ BBQ Grill ~ Couple's Retreat
A cozy living room with a wooden staircase, a chessboard on a round table, and a lamp on a side table.

7. The John Sydney House - Family and Pet Friendly Historic Home Downtown

The John Sydney House - Family and Pet Friendly Historic Home Downtown
Hannibal
9.6 out of 10, Exceptional, (28 reviews)
"Rooms were clean and the decor was very well done! We loved our stay here and the hosts were responsive to all our needs."
United States
Brian H.
The price is ￥23,462
￥36,357 total
includes taxes & fees
Nov 2 - Nov 3
The John Sydney House - Family and Pet Friendly Historic Home Downtown
A statue in a landscaped garden with a stone wall, surrounded by grass and trees.

8. Vibey home a few blocks from downtown Hannibal

Vibey home a few blocks from downtown Hannibal
Hannibal
9.8 out of 10, Exceptional, (17 reviews)
"Had a great time in Hannibal."
United States
Terry
The price is ￥14,418
￥45,623 total
includes taxes & fees
Nov 3 - Nov 4
Vibey home a few blocks from downtown Hannibal
Property grounds

9. Charming 2-bedroom house in nice Imperial with AC. Attn! Traveling Contractors

Charming 2-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
Imperial
9.8 out of 10, Exceptional, (8 reviews)
"Thank you we enjoyed the place but we would like to get some more nights if all possible"
United States
Tommy H.
The price is ￥12,306
￥18,909 total
includes taxes & fees
Nov 29 - Nov 30
Charming 2-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
A modern kitchen with wooden cabinets, stainless steel appliances, and a large island with bar stools.

10. Shouse Near Mark Twain Lake!

Shouse Near Mark Twain Lake!
Monroe City
10.0 out of 10, Exceptional, (13 reviews)
"This was our second stay, and it was just as great as the first time! Plenty of room to play, huge TVs for family movie night, and a well equipped kitchen for serving meals. Thank you! "
United States
Christina H.
The price is ￥36,287
￥51,611 total
includes taxes & fees
Nov 12 - Nov 13
Shouse Near Mark Twain Lake!
A covered patio with string lights, a seating area, and a small table.

11. TJ’s Country Getaway- Dog Friendly

TJ’s Country Getaway- Dog Friendly
Union
10.0 out of 10, Exceptional, (54 reviews)
"The property was great, cozy touches, clean and simply lovely. It was great to be able to travel with my dog!"
United States
Sherry
TJ’s Country Getaway- Dog Friendly
A living room with a grey sofa, a white coffee table, and teal chairs. A kitchen is visible through an open door.

12. Modern and comfy home five minutes from downtown

Modern and comfy home five minutes from downtown
Hannibal
10.0 out of 10, Exceptional, (22 reviews)
"House was perfect for our stay."
United States
Brent W.
The price is ￥15,527
￥46,733 total
includes taxes & fees
Nov 1 - Nov 2
Modern and comfy home five minutes from downtown
A porch with two turquoise Adirondack chairs and a small table, surrounded by well-maintained greenery and a white house with black shutters.

13. WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL

WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
Augusta
10.0 out of 10, Exceptional, (42 reviews)
"This is a fantastic place to stay. We will return in the future."
United States
Mike S.
The price is ￥25,717
￥46,560 total
includes taxes & fees
Nov 9 - Nov 10
WELCOME TO THE OWL'S NEST - 2 BEDROOM HOME IN AUGUSTA, WINERIES & THE KATY TRAIL
A dining area with a wooden table, grey upholstered chairs, a bench, a patterned rug, a brick wall, a framed picture, and a potted plant.

14. Centrally located in the Tower Grove East neighborhood!

Centrally located in the Tower Grove East neighborhood!
Tower Grove East
9.8 out of 10, Exceptional, (180 reviews)
"Great place!"
United States
Arthur S.
The price is ￥10,664
￥24,213 total
includes taxes & fees
Nov 1 - Nov 2
Centrally located in the Tower Grove East neighborhood!
A living room with a TV, wooden furniture, a fireplace, and a cozy seating area.

15. Charming 2-bedroom, cozy bungalow with sunroom in fabulous St. Louis with WiFi

Charming 2-bedroom, cozy bungalow with sunroom in fabulous St. Louis with WiFi
Bevo Mill
9.0 out of 10, Wonderful, (38 reviews)
"We enjoyed our stay, very quaint house and Julie was an amazing host "
United States
Lori O.
The price is ￥18,775
￥39,088 total
includes taxes & fees
Nov 10 - Nov 11
Charming 2-bedroom, cozy bungalow with sunroom in fabulous St. Louis with WiFi
A two-story house with a covered porch, a stone facade, and a well-maintained lawn.

16. Kid and pet friendly 2 nd floor duplex

Kid and pet friendly 2 nd floor duplex
Pacific
9.0 out of 10, Wonderful, (32 reviews)
"Very clean, nicely decorated."
United States
Amanda Q.
The price is ￥24,494
￥31,194 total
includes taxes & fees
Nov 8 - Nov 9
Kid and pet friendly 2 nd floor duplex
A two-story house with a blue exterior, a front porch, and a small front yard.

17. Hickory Lake House

Hickory Lake House
3.0 star property
Wright City
The price is ￥44,165
￥69,333 total
includes taxes & fees
Nov 5 - Nov 6
Hickory Lake House
A modern living room with a sofa, a wooden dining table with stools, a kitchen area with cabinets and a TV, and a hallway leading to a door.

18. Family friendly 3 bedroom home in Kahoka MO

Family friendly 3 bedroom home in Kahoka MO
Kahoka
9.4 out of 10, Exceptional, (13 reviews)
"Absolutely friendly and welcoming hosts. "
United States
Jay M.
The price is ￥22,482
￥34,550 total
includes taxes & fees
Nov 8 - Nov 9
Family friendly 3 bedroom home in Kahoka MO
A residential building with a patio area featuring outdoor furniture and string lights.

19. Private Entry Basement Suite • Pond & Farm View • Dog Friendly • St Peters

Private Entry Basement Suite • Pond & Farm View • Dog Friendly • St Peters
St. Peters
10.0 out of 10, Exceptional, (20 reviews)
"What a great place to stay! Clean, well stocked, and very spacious. Would definitely book again."
United States
Lynn D.
The price is ￥15,020
￥45,754 total
includes taxes & fees
Nov 1 - Nov 2
Private Entry Basement Suite • Pond & Farm View • Dog Friendly • St Peters
Eat in Kitchen for 6 with granite counters and stainless appliances

20. Historic Craftsman • Hot Tub • Walk to Wineries • Katy Trail

Historic Craftsman • Hot Tub • Walk to Wineries • Katy Trail
AUGUSTA
10.0 out of 10, Exceptional, (7 reviews)
"We had a great stay! The property is within walking distance of several shops & a cute cafe. The owner was very responsive."
United States
Claire M.
The price is ￥29,610
￥68,831 total
includes taxes & fees
Nov 4 - Nov 5
Historic Craftsman • Hot Tub • Walk to Wineries • Katy Trail
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Northeast Missouri Hotel Reviews

Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

8/10 Good
"The room and place were great but when we dropped off the car with the valet, our handicap placard was in the car and after we left, the placard was no longer in the car. 😩"
Andrea 1-night trip
Posted less than an hour ago
Courtyard by Marriott St. Louis Downtown/Convention Center

Find out more about Northeast Missouri

Northeast Missouri Vacation Homes information

Number of reviews
878
Accommodation
630 Vacation Homes
Lowest Price
￥18,909
Highest Price
￥69,333

Explore a world of travel with Expedia