Find Luxury Hotels in Mytilene

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Mytilene Luxury Hotels

Tonight
Apr 3 - Apr 4
Tomorrow
Apr 4 - Apr 5
This weekend
Apr 3 - Apr 5
Next weekend
Apr 10 - Apr 12

Our top choices for Mytilene luxury hotels

Free daily continental breakfast

Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel
4.0 star property
Lesvos
9.6 out of 10, Exceptional, (160 reviews)
  • cleanliness
    Luxuriate in this Lesvos boutique haven where pillowtop beds meet spa indulgences, all within steps of the beach and local art.
The price is ￥16,660
￥20,088 total
includes taxes & fees
Apr 8 - Apr 9
Theofilos Paradise Boutique Hotel
Seasonal outdoor pool

Heliotrope Hotels

Heliotrope Hotels
4.0 star property
Lesvos
8.6 out of 10, Excellent, (194 reviews)
The price is ￥14,047
￥17,225 total
includes taxes & fees
Apr 4 - Apr 5
Heliotrope Hotels
Garden

The Loriet

The Loriet
4.0 star property
Lesvos
8.4 out of 10, Very Good, (80 reviews)
The price is ￥10,825
￥13,699 total
includes taxes & fees
Apr 21 - Apr 22
The Loriet
Exterior

Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat
5.0 star property
Lesvos
8.6 out of 10, Excellent, (47 reviews)
  • cleanliness
    Seaside luxury awaits at this Greek retreat, where beachfront bliss meets wellness indulgence with 3 indoor pools and a full-service spa.
The price is ￥19,542
￥24,165 total
includes taxes & fees
Apr 17 - Apr 18
Mythical Coast Wellness Retreat
View from property

Elysion Hotel

Elysion Hotel
5.0 star property
Lesvos
9.2 out of 10, Wonderful, (46 reviews)
  • cleanliness
    Experience tranquil luxury and refined comfort at this 5-star seaside retreat with outdoor tennis courts and multiple dining options.
The price is ￥27,187
￥32,539 total
includes taxes & fees
Apr 6 - Apr 7
Elysion Hotel
Reception

Aeolian Gaea Hotel

Aeolian Gaea Hotel
4.0 star property
Lesvos
9.6 out of 10, Exceptional, (8 reviews)
The price is ￥21,176
￥25,039 total
includes taxes & fees
May 2 - May 3
Aeolian Gaea Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mytilene Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Mytilene vacation?
Mytilene has some interesting things to see and do including Port of Mytilene and Mytilini Castle, so you might want to take in the local sights during your visit.
What's the best luxury hotel in Mytilene?
Theofilos Paradise Boutique Hotel is a luxury hotel with a full-service spa and a seasonal outdoor pool, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Mythical Coast Wellness Retreat and Elysion Hotel are two other upscale options for your trip.
When can I expect good weather in Mytilene?
Planning for the weather is a good way to make your trip to Mytilene relaxing and enjoyable, especially when you're splurging. The hottest months are usually August and July with an average temp of 77°F, while the coldest months are January and February with an average of 52°F. Average annual precipitation for Mytilene is 34 inches.
What's there to see and do in Mytilene?
Take in the sights and attractions that Mytilene offers with a visit to Port of Mytilene, Mytilini Castle, and Olive-press Museum of Archipelagos Society. If you have a little extra time during your trip, you might want to make a stop at Teriade Museum and Roman Aqueduct at Moria.