Default HTG hotel image

Find hotels in Mesopotamia from ￥8,478

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Sep 29 - Sep 30
Tomorrow
Sep 30 - Oct 1
This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Filter by

Property class

Guest rating

Our top choices for Mesopotamia hotels

A spacious living room with a fireplace, comfortable seating, and a view of the outdoors.
A hotel room with a bed, a desk, a chair, a sofa, and a wardrobe.
A sunlit patio with round tables and chairs, surrounded by potted plants and flowers.
A modern bathroom with a glass shower enclosure, a white toilet, and a sink with a mirror above it.

1. To Spiti tis Sofias

To Spiti tis Sofias
Kastoria
Germany
Andreas Johann
￥10,724
￥12,537 total
includes taxes & fees
Oct 13 - Oct 14
To Spiti tis Sofias
A modern hotel exterior with outdoor seating, a staircase, and a glass entrance.
A multi-story hotel with balconies, a well-lit entrance, and a stone wall with the hotel name.
A breakfast setup with a tiered fruit and pastry display, a pitcher of orange juice, and a tropical fruit arrangement on a table with a white tablecloth.
A cozy room with a large flat-screen TV, a wooden table with a plant, and a view of the sea and mountains through a balcony.

2. Chloe Hotel

Chloe Hotel
Kastoria
United States
Tammy
￥11,033
￥13,424 total
includes taxes & fees
Sep 30 - Oct 1
Chloe Hotel
A pool area with a view of mountains and a lake, surrounded by lounge chairs and umbrellas.
A spacious bedroom with a large bed, a sofa, and a view of the outdoors.
A modern hotel entrance with stone pillars, a paved pathway, and decorative vases.
A table set with wine glasses and a rustic tablecloth, overlooking a lake with mountains in the background.

3. Limneon Resort & Spa

Limneon Resort & Spa
Kastoria
Canada
Konstantinos
￥16,550
￥21,480 total
includes taxes & fees
Sep 30 - Oct 1
Limneon Resort & Spa
A resort with a swimming pool, sun loungers, and a view of mountains.
A dining table with a steak, fries, and a salad, a wine glass, and a small potted plant.
A modern two-story building with a swimming pool, outdoor seating, and well-maintained gardens.
A modern building with a stone facade, large potted plants, and a well-lit entrance.

4. Calma Hotel & Spa

Calma Hotel & Spa
Kastoria
New Zealand
Robert
￥12,660
￥16,168 total
includes taxes & fees
Sep 30 - Oct 1
Calma Hotel & Spa
A spa area with a pool, stone walls, and a lantern.
A modern living room with a large sofa set, coffee tables, and decorative plants.
A modern interior with a central tree-like structure, large windows, and a dining area with tables and chairs.
A modern interior with a glass partition, a dining table, and two chairs.

5. Esperos Palace Luxury & Spa Hotel

Esperos Palace Luxury & Spa Hotel
Kastoria
United States
Michal
￥19,078
￥23,456 total
includes taxes & fees
Sep 30 - Oct 1
Esperos Palace Luxury & Spa Hotel
A hotel room with a bed, a window with a view of a town and hills, and a set of towels on the floor.
A modern kitchen with a bar area, bar stools, and a seating area with sofas.
A dining area with a glass table, metal chairs, and a view of a mountainous landscape through large windows.
A neatly made bed with white linens and towels, a small bedside table with a lamp, and a painting on the wall.

6. Kyknos De Luxe Hotel

Kyknos De Luxe Hotel
Kastoria
United Kingdom
Clare
￥13,397
￥15,572 total
includes taxes & fees
Oct 1 - Oct 2
Kyknos De Luxe Hotel
A hotel with outdoor seating and a well-lit facade.
A balcony with metal railings, a view of a lake, and purple flowers.
A brown sofa with two white cushions, a glass of champagne, and a fruit bowl with bananas, apples, and a pineapple on a white table.
A breakfast setting with a table set for two, including plates of eggs, toast, ham, cheese, and juice.

7. Hotel Anastassiou

Hotel Anastassiou
Kastoria
United States
Jeffrey
￥7,150
￥8,478 total
includes taxes & fees
Oct 1 - Oct 2
Hotel Anastassiou
Terrace/patio
Property entrance
Cafe
Living area

8. Orologopoulos Mansion

Orologopoulos Mansion
Kastoria
United Kingdom
elyahu
￥18,818
￥24,056 total
includes taxes & fees
Oct 1 - Oct 2
Orologopoulos Mansion
An outdoor patio with tables and chairs, a decorative urn, and a staircase leading to an upper level.
A modern bar area with a marble countertop, bar stools, and a large decorative vase.
A multi-story building with a grand entrance, a staircase, and a balcony.
A bedroom with a tufted headboard, a checkered bedspread, and a striped curtain.

9. Andromeda Boutique hotel

Andromeda Boutique hotel
Kastoria
￥11,223
￥16,325 total
includes taxes & fees
Oct 5 - Oct 6
Andromeda Boutique hotel
A dining area with a table set for two, overlooking a scenic view of trees and mountains through large windows.
A hotel room with a bed, a chair, a desk, and a view of the outside.
A living room with a grey sofa, a bookshelf, a red rug, and a framed picture on the wall.
A white two-story house with a balcony, surrounded by lush greenery and a well-maintained lawn.

10. Guesthouse Vissinokipos

Guesthouse Vissinokipos
Kastoria
United States
Carmen
￥11,213
￥13,091 total
includes taxes & fees
Sep 30 - Oct 1
Guesthouse Vissinokipos
A riverside walkway with chairs and tables, a bench, and buildings in the background.
A hotel lobby with a reception desk, a coffee table, a sofa, and a staircase.
A spacious living area with a staircase, a reception desk, and a seating area.
A hotel room with a bed, a nightstand, a lamp, and a door with a modern handle.

11. Anesis Hotel

Anesis Hotel
Kastoria
Canada
Adam
￥8,149
￥9,613 total
includes taxes & fees
Sep 30 - Oct 1
Anesis Hotel
A modern living room with a large white bathtub, a yellow sofa, and a kitchen area with wooden cabinets and potted plants.
A modern bathroom with a glass shower enclosure, a marble-tiled wall, a sink, and a potted plant.
A modern bathroom with a marble bathtub, a built-in heater, a window with blinds, and a small plant on the counter.
A compact kitchen with a built-in oven, a sink, and wooden cabinets. There is a small dining area with a round table and a yellow chair.

12. Lūma Retreat

Lūma Retreat
Kastoria
￥12,625
￥14,695 total
includes taxes & fees
Oct 6 - Oct 7
Lūma Retreat
A stone house with a balcony, steps leading to the entrance, and outdoor lighting.
A stone building with a patio, a table with chairs, and a large vase.
A rustic dining area with stone walls, wooden beams, and a bar with a stone countertop.
A cozy room with a fireplace, a sofa, a reading chair, and a window with a view.

13. Le Marron

Le Marron
Voio
￥18,807
￥23,148 total
includes taxes & fees
Oct 11 - Oct 12
Le Marron
A building with a stone staircase and a view of a green landscape.
A cozy living room with a red sofa, wooden coffee table, and a fireplace. There is a dining area with a table and chairs, and a large window offering a view of greenery.
A building with a sign reading "Hotel H. Fenusa" and a number "24680 71006". There are potted plants and a small table outside.
An outdoor patio with tables and chairs, surrounded by potted plants and a canopy.

14. Guest House Ilektra

Guest House Ilektra
Voio
United Kingdom
Maria
￥7,881
￥9,309 total
includes taxes & fees
Oct 2 - Oct 3
Guest House Ilektra
A cozy restaurant with wooden furniture, a bar area, and a fireplace.
An outdoor café with wicker furniture, stone flooring, and a staircase leading to an upper level.
A historic building with a clock tower, a stone facade, and a tree in the foreground.
A black metal side table with a patterned wallpaper background.

15. Guesthouse Monopati

Guesthouse Monopati
Amyntaio
￥10,400
￥12,169 total
includes taxes & fees
Oct 29 - Oct 30
Guesthouse Monopati
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Top Mesopotamia Hotel Reviews

Guesthouse Vissinokipos

Guesthouse Vissinokipos

10/10 Excellent
"Lovely place , great view , well maintained, clean and with fantastic people running it . When the owners are to one who welcome you and take care of everything you need you know you got to the right place . Wonderful place"
Avner 1-night trip
Posted 4 days ago
Guesthouse Vissinokipos
Kyknos De Luxe Hotel

Kyknos De Luxe Hotel

10/10 Excellent
"We had a lovely stay in kastoria, the hotel was great and breakfast was amazing. As a family of 4 the space in the room was ideal and the owners were extremely welcoming."
Clare 1-night trip
Posted 2 months ago
Kyknos De Luxe Hotel
Limneon Resort & Spa

Limneon Resort & Spa

10/10 Excellent
"We loved our stay very much and will definitely be returning from the staff to the location and simply beautiful views we couldn’t ask for anything better the only suggestion is that they add dresser’s with draws so you can putt your cloths out instead of having to use your suit cases."
George 16-night trip
Posted 2 months ago
Limneon Resort & Spa
Calma Hotel & Spa

Calma Hotel & Spa

10/10 Excellent
"If you’re looking for a hotel, that is clean, spacious, warm and inviting this is the place for you. It has the perfect location to be out of the way but close enough to all of Kastoria and surrounding villages. Staff were kind and exceptional. Everyone was extremely helpful, courteous and made us feel like we were home. Rooms are spacious, constantly clean and replenished with towels daily. We had a simple corner suite that didn’t overlook much in a view but it was quiet all day long which was refreshing. Pool was beautifully maintained as well as the entire property. Pool did get very busy with locals due to the extreme heat, but with a morning reservation at the pool you had no problem having a spot even if you came back late in the afternoon. Breakfast was delicious with its standard staples but with new items as well. We cannot be more happy with our stay and we hope that you will consider booking this location as we know you will not be disappointed."
Patricia 10-night trip
Posted 2 months ago
Calma Hotel & Spa
Orologopoulos Mansion

Orologopoulos Mansion

10/10 Excellent
"This is the hotel we return to time and time again, and the one we are never disappointed by. * Clean: Perfectly clean. Daily refresh of linens and tidying of room. Public spaces pristine. Black out shades were a pleasant surprise in an antique building like this one. Loved that touch! * Customer service. Top-tier service. Warm and friendly but also give space. * Breakfast. Delicious pites, pastries, yogurt. Choice of barista-quality coffees. Lovely space to eat, both inside and outside in their private garden. * Location. One block from the lake (GREAT for jogging) and across the street from the plateia (square), with its choice of chic restaurants. Quiet when you need it to be. * Parking. Right in front every day, with no issue whatsoever. Always a perfect stay. Love this hotel!"
Paula 3-night trip
Posted 3 months ago
Orologopoulos Mansion
Guest House Ilektra

Guest House Ilektra

10/10 Excellent
"Friendly and courteous hosts, great food and excellent service "
Pantelia 1-night trip
Posted 10 months ago
Guest House Ilektra

More cheap stays in Mesopotamia

Hotel Anastassiou

Hotel Anastassiou

1st km Highway Kastoria-Athens Kastoria Western Macedonia
￥7,150
￥8,478 total
Oct 1 - Oct 2
includes taxes & fees
Hotel Anastassiou
Arhontiko Christodoulou

Arhontiko Christodoulou

vrontero Prespes
￥7,686
￥9,087 total
Oct 30 - Oct 31
includes taxes & fees
Arhontiko Christodoulou
Anesis Hotel

Anesis Hotel

Grammou 10 Kastoria
￥8,149
￥9,613 total
Sep 30 - Oct 1
includes taxes & fees
9/10 Wonderful! (9 reviews)
Anesis Hotel

Frequently asked questions

Where is the best place for a stay in Mesopotamia?
To Spiti tis Sofias is one of the top choices for your stay based on our traveler data. This guesthouse offers free parking and free WiFi. Two other choices for your visit to the area are Limneon Resort & Spa and Hotel Anastassiou. See all available top hotels, or vacation rentals in Mesopotamia.
What are some of the best vacation home rentals that Mesopotamia has to offer?
Anastasia s Kastoria Cozy Modern Garden Retreat: This vacation home rental outside of Mesopotamia offers a garden, a barbecue grill, and free WiFi to help you feel perfectly comfortable in your new surroundings. This vacation rental also comes with free parking to give you added peace of mind. See all vacation rentals in Mesopotamia.
If I need to cancel my hotel reservation in Mesopotamia, will I receive a refund?
Yes! You'll find that most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Mesopotamia.
Where can I learn more about changing or cancelling my trip to Mesopotamia?
For more details about picking new dates or cancelling your trip to Mesopotamia, click here.
What is the best accommodation for staying close to Macedonia Airport (SKG)?
Hyatt Regency Thessaloniki is a popular 5-star hotel featuring 2 outdoor pools and a full-service spa. It's located a short 1.1 mi (1.8 km) from Macedonia Airport. Other options near the airport are Athina Airport Hotel and Hotel Nikopolis.
What is staying in Mesopotamia like?
Travelers to Mesopotamia will find plenty to explore and enjoy. There are 49 hotels and other accommodations in the surrounding area. Find out more about Mesopotamia.
What are the top places to visit in Mesopotamia?
Places to visit in the wider area include Neolithic Lakeside Settlement, Kastoria Lake, and Folklore Museum of Kastoria. You'll also find Taxiarhia of the Metropolis and Kastoria Aquarium in the area. Check out what more to see and do in Expedia's Mesopotamia guide.
What's the seasonal weather like in Mesopotamia?
The hottest months are usually August and July with an average temp of 69°F, while the coldest months are January and February with an average of 37°F. Average annual precipitation for Mesopotamia is 28 inches.

Explore a world of travel with Expedia