Find hotels in Mesopotamia from ¥5,609

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Compare 501 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Mesopotamia hotels

Hathor Concordia

3.0 star property
8.6 out of 10, Excellent, (351)
"Very clean room at affordable price. The dinning is of excellent quality at very reasonable price. The staff are quite friendly and helpful."
Hathor Concordia

Mayim Hotel Termal & SPA

3.0 star property
9.0 out of 10, Wonderful, (4)
"Muito bom o hotel. Atendimento excelente e comida também "
The price is ¥12,619
¥12,619 total
Aug 25 - Aug 26
Mayim Hotel Termal & SPA

El Tránsito Hotel Boutique

3.5 star property
10.0 out of 10, Exceptional, (3)
"This is an excellent Hotel and experience. The staff is vibrant and attentive. I would rate this hotel as one of the best, if not the best hotel I have ever stayed at. "
The price is ¥64,580
¥64,580 total
Aug 21 - Aug 22
El Tránsito Hotel Boutique

Hotel y Spa Termas del Este

3.0 star property
8.4 out of 10, Very Good, (12)
"good for a 1 night stay"
Hotel y Spa Termas del Este

Totoras Apart Federacion

2.5 star property
7.2 out of 10, Good, (25)
"Buena estadia para unos dias .todo muy limpio a pesar de que estan aun terminando dptos.tal vez deben cuidar más los horarios de descanso del turista con los ruidos de la obra . Pocos utensilios de cocina si se quiere cocinar ahi mismo.Pero tranquilo y suficiente"
Totoras Apart Federacion

Urban Hotel

3.0 star property
2.0 out of 10, (1)
"Ambiente deixa a desejar, muito sujo, café da manhã ruim, sem opção. Baratas no ambiente."
Urban Hotel

O2 Hotel Gualeguaychú

2.5 star property
7.6 out of 10, Good, (61)
"Hotel is very comfortable and clean. There is no breakfast or hotel parking, and the wifi does not work properly in most floors and rooms. Other than that, the staff is very friendly and nice. "
The price is ¥5,609
¥5,609 total
Aug 27 - Aug 28
O2 Hotel Gualeguaychú

Costarenas Hotel & Spa

3.5 star property
8.8 out of 10, Excellent, (55)
Costarenas Hotel & Spa

COSTA NORTE HOSTERIA

3.0 star property
The price is ¥7,355
¥7,355 total
Aug 24 - Aug 25
COSTA NORTE HOSTERIA

Intersur Colon

3.0 star property
10.0 out of 10, Exceptional, (2)
"Letti molto comodi, belle piscine, personale gentile, pulizia buona, colazione buona. Ottimo rapporto qualità prezzo. "
The price is ¥15,190
¥15,190 total
Aug 21 - Aug 22
Intersur Colon

Posada Che Teindy

2.5 star property
The price is ¥15,836
¥15,836 total
Aug 25 - Aug 26
Posada Che Teindy

Maran Suites & Towers - Hotel & Spa

3.5 star property
9.0 out of 10, Wonderful, (30)
"Great location and friendly, accommodating staff. "
The price is ¥14,666
¥14,666 total
Aug 25 - Aug 26
Maran Suites & Towers - Hotel & Spa

Hotel Rio

3.0 star property
8.8 out of 10, Excellent, (11)
"Lindo hotel, moderno, limpio, buena atencion, sumaria opciones saladas en el desayuno, como huevos revueltos."
The price is ¥12,621
¥12,621 total
Sep 3 - Sep 4
Hotel Rio

Donsuites Apart Hotel

3.0 star property
8.6 out of 10, Excellent, (104)
"Loved this place, super clean, and the staff were very nice and helpful😍"
The price is ¥10,287
¥10,287 total
Aug 21 - Aug 22
Donsuites Apart Hotel

Agustín 1 Apart

4.0 star property
9.0 out of 10, Wonderful, (4)
The price is ¥6,642
¥6,642 total
Sep 2 - Sep 3
Agustín 1 Apart

Casa del Árbol

3.0 star property
8.0 out of 10, Very Good, (7)
"La primera vez que venga a Concepcion del Uruguay, quiero alquilar en" la casa del arbol" Me sentí muy bienvenida y en buena compañía, los anfitriones son maravillosos "
The price is ¥3,454
¥3,454 total
Aug 21 - Aug 22
Casa del Árbol

Bungalows Mexico

2.5 star property
8.8 out of 10, Excellent, (12)
"Local estava limpo, a cama é ótima, mas o banheiro a água n esquentava. O atendimento foi bom, são atenciosos. "
The price is ¥6,501
¥6,501 total
Aug 22 - Aug 23
Bungalows Mexico

Club Valle Termal Resort

3.0 star property
9.2 out of 10, Wonderful, (93)
The price is ¥7,573
¥7,573 total
Aug 21 - Aug 22
Club Valle Termal Resort

La Alondra Casa De Huéspedes

4.0 star property
9.2 out of 10, Wonderful, (63)
La Alondra Casa De Huéspedes

La Casona de Susana

3.0 star property
7.4 out of 10, Good, (25)
The price is ¥7,085
¥7,085 total
Aug 26 - Aug 27
La Casona de Susana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Mesopotamia

Showing deals for:Aug 29 - Aug 31
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Mesopotamia

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

Mesopotamia showing a river or creek and forest scenes

Top Mesopotamia Hotel Reviews