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Find Resorts & Hotels with Spas in Los Osos, CA

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Check availability on Los Osos Resorts & Hotels with Spas

Our top choices for Los Osos hotels with a spa

Outdoor pool
Sea Pines Resort

Sea Pines Resort

Sea Pines Resort
3.0 star property
Los Osos
8.2 out of 10, Very Good, (410)
"Nice staff."
United States
Ann
Sea Pines Resort
Property entrance
Avila Village Inn

Avila Village Inn

Avila Village Inn
3.5 star property
Avila Beach
9.2 out of 10, Wonderful, (1000)
"The property and rooms were beautiful! We really enjoyed our weekend here and are planning to stay again!"
United States
Cathy
Avila Village Inn
Caveman | Bathroom | Shower, hair dryer, bathrobes, towels
Madonna Inn

Madonna Inn

Madonna Inn
3.5 star property
San Luis Obispo
9.2 out of 10, Wonderful, (1324)
"We love this place!"
United States
Jennifer
The price is ￥21,029
￥29,207 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Madonna Inn
Restaurant
The Agrarian Hotel, BW Signature Collection

The Agrarian Hotel, BW Signature Collection

The Agrarian Hotel, BW Signature Collection
2.5 star property
Arroyo Grande
9.6 out of 10, Exceptional, (1000)
"The room was super comfortable and clean. They offered a great breakfast too!"
United States
kim
The price is ￥19,157
￥21,780 total
includes taxes & fees
Dec 12 - Dec 13
The Agrarian Hotel, BW Signature Collection
Exterior
Cayucos Sunset Inn B&B

Cayucos Sunset Inn B&B

Cayucos Sunset Inn B&B
3.5 star property
Cayucos
9.8 out of 10, Exceptional, (195)
"Great place to stay"
United States
Jason
The price is ￥27,199
￥30,599 total
includes taxes & fees
Dec 22 - Dec 23
Cayucos Sunset Inn B&B
Reception
HOTEL CERRO, Autograph Collection

HOTEL CERRO, Autograph Collection

HOTEL CERRO, Autograph Collection
4.0 star property
Downtown San Luis Obispo
9.2 out of 10, Wonderful, (468)
"We had a great stay"
United States
ADALBERT
The price is ￥35,755
￥46,000 total
includes taxes & fees
Dec 15 - Dec 16
HOTEL CERRO, Autograph Collection
Property grounds
Avila La Fonda Hotel

Avila La Fonda Hotel

Avila La Fonda Hotel
4.0 star property
Avila Beach
9.6 out of 10, Exceptional, (1000)
"Very nice hotel. Great for and rest and relaxation kind of vacation"
United States
Princess
The price is ￥29,210
￥32,862 total
includes taxes & fees
Dec 22 - Dec 23
Avila La Fonda Hotel
Morro Suite | Living area | 55-inch flat-screen TV with cable channels, TV
Hotel San Luis Obispo

Hotel San Luis Obispo

Hotel San Luis Obispo
4.5 star property
Downtown San Luis Obispo
9.4 out of 10, Exceptional, (546)
"Beautiful room and nice rooftop bar!"
United States
Chizuru
The price is ￥46,434
￥52,702 total
includes taxes & fees
Dec 14 - Dec 15
Hotel San Luis Obispo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Los Osos Hotel Reviews

Apple Farm

Apple Farm

10/10 Excellent
"Courteous and friendly. Very helpful "
shannon 1-night trip
Posted 21 hours ago
Apple Farm

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Frequently asked questions

Looking for a spa hotel in Los Osos?
Forget the stress of everyday life and book yourself a hotel with a spa. Check out the beaches in Los Osos - worth a picture or two! Take part in recreational activities such as golfing during your vacation. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your vacation.
What is the best spa hotel in Los Osos?
Sea Pines Resort is a top spa hotel featuring a golf course, a bar, and a restaurant. Spend an afternoon at the spa where you'll find deep-tissue massages, hot stone massages, and couples treatments.
How many spa hotels will I find in Los Osos?
Among Expedia's 45 accommodation options in Los Osos, there is 1 spa hotel.
What's there to see and do in Los Osos?
Experience Los Osos with a stop at Los Osos Oaks State Reserve, Elfin Forest Preserve, and Montaña de Oro State Park. If you have a bit of extra time while you're in the area, you might want to check out Morro Bay State Park and Morro Coast Audubon Society Sweet Springs Nature Preserve.
What is a Los Osos spa hotel?
Spa hotels in Los Osos provide lodging and have an on-site spa which offers services such as facials as well as body treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.