Lake City Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Dec 26 - Dec 28
In two months
Feb 6 - Feb 8
In three months
Mar 6 - Mar 8
In four months
Apr 3 - Apr 5

Our top choices for Lake City vacation rentals

Interior
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Vacation Home in Florence

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
10.0 out of 10, Exceptional, (35)
"Perfect stay for our family wedding weekend!! Home was immaculate and a perfect layout! Host has thought of everything you may need during your stay from extra linens to a fully stocked kitchen. Awesome location and super nice neighborhood!"
United States
Cathy D.
The price is ￥36,947
￥46,474 total
includes taxes & fees
Dec 23 - Dec 24
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Smart TV, fireplace
Pineapple House: Historic. Southern Charm. Walk Downtown.

Vacation Home in Florence

Pineapple House: Historic. Southern Charm. Walk Downtown.
9.6 out of 10, Exceptional, (19)
"This was a very nice property and very comfortable. We enjoyed our stay there."
United States
Gary B.
Pineapple House: Historic. Southern Charm. Walk Downtown.
1 bedroom, iron/ironing board, WiFi, bed sheets
Charming 1-bedroom cabin in welcoming Florence with AC and heating

Cabin in Florence

Charming 1-bedroom cabin in welcoming Florence with AC and heating
2.0 star property
Charming 1-bedroom cabin in welcoming Florence with AC and heating
Interior
Walking distance from one of South Carolina's top Medical centers.

Vacation Home in Florence

Walking distance from one of South Carolina's top Medical centers.
9.8 out of 10, Exceptional, (42)
"The house was beautiful. We would stay there again!!"
United States
Stephanie L.
The price is ￥20,885
￥36,299 total
includes taxes & fees
Dec 14 - Dec 15
Walking distance from one of South Carolina's top Medical centers.
Smart TV
Great Home in the Greater Florence Area

Vacation Home in Timmonsville

Great Home in the Greater Florence Area
9.6 out of 10, Exceptional, (9)
"Great property for a guys weekend. Matthew was very responsive with questions I had. I would absolutely stay here again. "
United States
Frank V.
Great Home in the Greater Florence Area
Fridge, microwave, oven, stovetop
Creekside Country Cottage- minutes away from I-95

Cottage in Manning

Creekside Country Cottage- minutes away from I-95
10.0 out of 10, Exceptional, (9)
"Great place beautiful and the dogs loved it"
United States
Jennifer T.
The price is ￥35,042
￥68,112 total
includes taxes & fees
Dec 15 - Dec 16
Creekside Country Cottage- minutes away from I-95
Dining
Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

Vacation Home in Florence

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
2.0 star property
8.0 out of 10, Very Good, (1)
"Tracey was very accomodating given our last minute request since a previous host had cancelled on us the day before our trip. However, the home was not clean upon arrival and one of the hosts had to fix a breaker, a chirping smoke detector, and bring us towels. He pointed out the newly water damaged ceilings as well. "
United States
Emily S.
Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
Living area
3-bedroom mobile home in peaceful Florence with AC, WiFi

Mobile Home in Florence

3-bedroom mobile home in peaceful Florence with AC, WiFi
10.0 out of 10, Exceptional, (1)
"We had a great stay for a quick weekend wedding. "
United States
John D.
3-bedroom mobile home in peaceful Florence with AC, WiFi
Interior
Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees

Vacation Home in Florence

Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees
9.8 out of 10, Exceptional, (6)
"Everything about this location was great and the host was very kind. Thank you for making our stay comfortable. "
United States
Shatia G.
Charming and Cozy 4BR 2BA House with Parking, Minutes from I-95 and Buc-ees
Property grounds
Family Retreat for vacations, weddings, family reunions and corporate retreats.

Cabin in Florence

Family Retreat for vacations, weddings, family reunions and corporate retreats.
10.0 out of 10, Exceptional, (1)
"Great location and property."
United States
Jerry W.
Family Retreat for vacations, weddings, family reunions and corporate retreats.
Interior
Relaxing 3-Bedroom Getaway in Peaceful Cades – Sleeps 8

Vacation Home in Cades

Relaxing 3-Bedroom Getaway in Peaceful Cades – Sleeps 8
Relaxing 3-Bedroom Getaway in Peaceful Cades – Sleeps 8
Interior
Hickory Haven 3Br Elegant Downtown Hidden Gem

Vacation Home in Florence

Hickory Haven 3Br Elegant Downtown Hidden Gem
9.6 out of 10, Exceptional, (19)
"This home was perfect for our family. Would definitely recommend to anyone looking for a place to stay in the Florence area. "
United States
Bryan B.
Hickory Haven 3Br Elegant Downtown Hidden Gem
House (5 Bedrooms) | Interior
3-story Home w/ Private Backyard in Florence!

Cottage in Florence

3-story Home w/ Private Backyard in Florence!
3.0 star property
3-story Home w/ Private Backyard in Florence!
Interior
Charming 3-bedroom house in Florence, SC

Vacation Home in Florence

Charming 3-bedroom house in Florence, SC
8.0 out of 10, Very Good, (1)
"Property was clean and inviting. The only issue we had was the ac wasnt cool enough for us. (We work outside)"
United States
Ben P.
Charming 3-bedroom house in Florence, SC
Living area
Elegant Historic Home w/ Modern Touch in Florence

Vacation Home in Florence

Elegant Historic Home w/ Modern Touch in Florence
8.0 out of 10, Very Good, (1)
"We came to visit my godchild and enjoyed visiting with his family. This home is a beautiful house and with it being a fairly new listing it had some hiccups that could be work on, but other then that the neighborhood is quite"
United States
Nikki R.
Elegant Historic Home w/ Modern Touch in Florence
Dining
Charming 1-bedroom house in awesome Kingstree with AC, WiFi

Vacation Home in Kingstree

Charming 1-bedroom house in awesome Kingstree with AC, WiFi
Charming 1-bedroom house in awesome Kingstree with AC, WiFi
Fridge, microwave, oven, stovetop
Luxury stay at 4 bedroom house

Vacation Home in Florence

Luxury stay at 4 bedroom house
9.0 out of 10, Wonderful, (2)
"We needed a place to stay, close to a wedding venue and this house was Perfect for our large family. Very clean, roomy, and well stocked. Zilola was so nice and quick to respond."
United States
Minette E.
Luxury stay at 4 bedroom house
Interior
Cozy Work Friendly Condo in Florence

Condo in Florence County

Cozy Work Friendly Condo in Florence
9.0 out of 10, Wonderful, (10)
"Great place to stay and work from home and great tv for movie nights!"
United States
Tj R.
Cozy Work Friendly Condo in Florence
Property grounds
Camping it is!

Camping in Kingstree

Camping it is!
Camping it is!
Microwave, oven, stovetop, dishwasher
Cozy Retreat in Florence, SC

Vacation Home in Florence

Cozy Retreat in Florence, SC
Cozy Retreat in Florence, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Lake City Hotel Reviews

Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

10/10 Excellent
"Friendly staff and great breakfast"
Jo 1-night trip
Posted 3 days ago
Hampton Inn & Suites Florence Center

Find out more about Lake City

Search for holiday rentals in Lake City on Expedia! You can easily find your home rentals, villas, holiday apartments in Lake City using one of the methods below:

  • View our selection of featured holiday rentals in Lake City
  • Use the map to find apartments and other holiday homes in the Lake City neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Lake City while they last

Look no further and take a look at our great range of rental properties in Lake City!

Frequently asked questions

Can I find a vacation rental in Lake City?

Yes, we offer vacation rentals in Lake City near Moore Farms Botanical Garden, or you can choose a secluded option if you want a relaxing stay. Visitors to Lake City speak positively about the lakeside and restaurants in this destination. Make sure you have time to check out the shopping and parks during your trip.

What are some of the best vacation rentals that Lake City has to offer?

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's: This vacation home rental outside of Lake City offers a fireplace, a patio, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the garden in this rental home to help you unwind.

What can I see and do in Lake City?

Lions Park and Ronald E. McNair Life History Center are a couple of lovely local spots to get outside and enjoy nature. The Country Club at Lake City and Lynches Lake Historical Society are other places to visit while you're in town.

What are vacation rentals like in Lake City?

Vacation rentals are private properties you can stay in for a couple days or more in Lake City. Vacation rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a clean environment, vacation rentals can offer a sense of seclusion away from public hotel elevators and bustling concierge desks while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a great choice for family trips or small group gatherings.