A densely packed urban area with numerous buildings and a prominent tower on a hill.

Find hotels in Puerto Santa Ana, Guayaquil

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Jul 24 - Jul 26
Next weekend
Jul 31 - Aug 2

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Puerto Santa Ana hotels

2 bars/lounges, lobby lounge

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.2 out of 10, Wonderful, (1,002 reviews)
"Nice river view, clean room, nice staff and breakfast buffet great!!!"
United States
Nancy
The price is ￥16,223
￥18,657 total
Aug 16 - Aug 17
Wyndham Guayaquil Puerto Santa Ana
Outdoor spa tub

2. Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (107 reviews)
"Lots of restaurants nearby"
Canada
kevin
The price is ￥13,875
￥14,199 total
Jul 22 - Jul 23
Luxury Suites Riverfront GYE
Rooftop terrace

3. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (58 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ￥11,190
￥13,138 total
Jul 21 - Jul 22
River View suites Puerto Santa Ana gye
Lobby lounge

4. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (142 reviews)
"Breakfast was good. I enjoyed my scrambled eggs and toast "
United States
Caitlin
The price is ￥9,646
￥10,935 total
Jul 22 - Jul 23
Mansión del Río
Food and drink

5. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very Good, (157 reviews)
"The pool was enjoyable but going during the day so the water isn’t as cold."
United States
Julio
The price is ￥7,196
￥7,358 total
Jul 21 - Jul 22
Hotel Patrimonial by Greenfield
Lobby

6. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (940 reviews)
"Excellent service"
United States
Maritza
The price is ￥9,653
￥11,106 total
Jul 25 - Jul 26
Hotel Palace Guayaquil
Outdoor pool, open 8:00 AM to 9:00 PM, sun loungers

7. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,002 reviews)
"Great place to stay"
United States
Martha Lucia
The price is ￥12,212
￥13,921 total
Aug 14 - Aug 15
Grand Hotel Guayaquil, Centro Histórico.
Front of property

8. Hotel Sada

Hotel Sada
3.0 star property
Roca, 1.5 km from Puerto Santa Ana
9.8 out of 10, Exceptional, (12 reviews)
"Habitación limpia, personal amable, y desayuno fresco. "
Mexico
Ligia
The price is ￥7,530
￥7,854 total
Jul 21 - Jul 22
Hotel Sada
Restaurant

9. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (319 reviews)
"Clean room and friendly environment. Well located in front of Malecón 2000"
Canada
Gonzalo
The price is ￥8,770
￥10,135 total
Jul 24 - Jul 25
Ibis Styles El Malecon Guayaquil
Rooftop bar, alfresco dining, open daily

10. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,001 reviews)
"The room was really clean and the staff in the lobby were really helpful. Breakfast was good"
United States
Rosa
The price is ￥13,008
￥14,796 total
Jul 26 - Jul 27
Wyndham Garden Guayaquil
Children's activities

11. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,008 reviews)
"Definitely the best and friendliest Hotel in Guayaquil!"
United States
Josef Walter
The price is ￥13,804
￥15,996 total
Aug 8 - Aug 9
Oro Verde Guayaquil
Ecotours

12. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
8.4 out of 10, Very Good, (8 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is ￥6,594
￥6,918 total
Aug 20 - Aug 21
Fortune Hotel
Indoor pool, open 8:00 AM to 10 PM, sun loungers

13. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very Good, (407 reviews)
"Enjoyed a weekend in Guayaquil. Staff is attentive and genuinely helpful. The hotel is an older property but well-maintained — good price point for the area and what it offers. Breakfast was good. Solid choice for a quiet, relaxed stay in a central location"
United States
Hugo
The price is ￥10,232
￥10,556 total
Jul 21 - Jul 22
Hotel Ramada
Comfort Double Room | In-room safe, desk, WiFi (free), bed sheets

14. Hotel GH Alexander

Hotel GH Alexander
3.5 star property
Rocafuerte, 2.1 km from Puerto Santa Ana
8.6 out of 10, Excellent, (43 reviews)
"Great value hot water clean friendly staff on site restaurant "
United States
Monty
The price is ￥5,627
￥5,951 total
Jul 21 - Jul 22
Hotel GH Alexander
Lobby

15. Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil
5.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (114 reviews)
"Good staff...great location"
United States
ALBERTO
The price is ￥13,184
￥15,720 total
Aug 2 - Aug 3
Doubletree By Hilton Guayaquil
Minibar (free items), in-room safe, soundproofing

16. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (3 reviews)
"The staff was very friendly and helpful. The hotel is new and modern, it is a good place to relax and work. "
United States
Richard
The price is ￥63,336
￥70,604 total
Aug 9 - Aug 10
Hotel Río Guayas by Art Hotels Ecuador
Down comforters, desk, WiFi (free), bed sheets

17. Hotel Las Peñas

Hotel Las Peñas
3.0 star property
Rocafuerte, 1.8 km from Puerto Santa Ana
8.4 out of 10, Very Good, (120 reviews)
"The breakfast was excellent."
United States
judith
The price is ￥6,236
￥8,184 total
Jul 28 - Jul 29
Hotel Las Peñas
Property entrance

18. DC Suites Aeropuerto

DC Suites Aeropuerto
3.0 star property
Simón Bolívar, 3 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (643 reviews)
"Nice, clean simple, family run hotel with good transportation."
United States
Gerald
The price is ￥5,846
￥6,008 total
Jul 21 - Jul 22
DC Suites Aeropuerto
Superior Double Room, 2 Twin Beds | WiFi (free), bed sheets

19. Hotel GH Sander

Hotel GH Sander
3.0 star property
Rocafuerte, 2.1 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (27 reviews)
"Excelente "
Mexico
Andres
The price is ￥5,387
￥5,387 total
Jul 21 - Jul 22
Hotel GH Sander
Suite, Jetted Tub | In-room safe, WiFi (free), bed sheets

20. Hotel Varadero Internacional

Hotel Varadero Internacional
3.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
8.2 out of 10, Very Good, (77 reviews)
"Overall a good place to stay and close to most destinations."
United States
Daniel
The price is ￥4,421
￥4,745 total
Aug 9 - Aug 10
Hotel Varadero Internacional
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

An iguana on green grass.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Central Market while you're in town.

A cityscape with colorful buildings, a prominent church, and a hill with residential structures.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or Policentro while you're exploring the area.

A green and yellow iguana on a rocky surface.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to Alban Borja Commercial Center or San Marino Mall.

Top Puerto Santa Ana Hotel Reviews

River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye

10/10 Excellent
"Very good"
Poul Anthony 1-night trip
Posted 9 hours ago
River View suites Puerto Santa Ana gye

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 83 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Botanical Garden are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Santa Ana Hill and Numa Pompilio Llona Street are a couple of additional sights to visit in Guayaquil.