Find hotels near Fort Defiance State Park, Cairo from ￥10,481

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Dec 24 - Dec 25
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Dec 25 - Dec 26
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Dec 26 - Dec 28
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Jan 2 - Jan 4

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Our top choices for Fort Defiance State Park hotels

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Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
7.8 km from Fort Defiance State Park
6.6 out of 10, (274)
"Break fast was excellent "
United States
Uma
The price is ￥11,072
￥12,287 total
includes taxes & fees
Jan 17 - Jan 18, 2026
Quality Inn Cairo I-57
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
17.5 km from Fort Defiance State Park
6.6 out of 10, (613)
"Staff was great! Room was nice. "
United States
Lana
The price is ￥9,695
￥10,758 total
includes taxes & fees
Dec 28 - Dec 29
Super 8 by Wyndham Charleston/Sikeston East MO
Room, 1 King Bed, Non Smoking | View from room
Eagle Inn Charleston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
16.2 km from Fort Defiance State Park
6.6 out of 10, (105)
"Middle of nowhere hotel was ok"
United States
David
The price is ￥9,444
￥10,481 total
includes taxes & fees
Dec 25 - Dec 26
Eagle Inn Charleston
Basic Double Room | Living area
La Center Motel

La Center Motel

La Center Motel
2.0 star property
17.5 km from Fort Defiance State Park
7.8 out of 10, Good, (17)
"Quiet and convenient."
United States
Alma
La Center Motel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Fort Defiance State Park Hotel Reviews

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"Super spacious room and delightful staff. Recommended to ALL "
James 1-night trip
Posted 4 days ago
Days Inn and Suites by Wyndham Sikeston

Hotels near other Fort Defiance State Park attractions

Columbus-Belmont State Park

3.7/5 (18 reviews)
You can learn about the history of Columbus with a stop at Columbus-Belmont State Park.
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Ullin City Hall

After visiting Ullin City Hall, make a plan to see the other sights and activities in Ullin. Amble around the area's parks or experience its museums.
See properties

Frequently asked questions

What's the area like around Fort Defiance State Park?
Fort Defiance State Park is located in Cairo. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.
What's the best place to stay close to Fort Defiance State Park?
Quality Inn Charleston - Sikeston is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. You'll find it 12.6 mi (20.2 km) from Fort Defiance State Park. Other good choices around the area include Super 8 by Wyndham Charleston/Sikeston East MO and Drury Inn & Suites Sikeston, MO.
If I need to cancel the hotel reservation for my stay near Fort Defiance State Park, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best options available near Fort Defiance State Park.
Where can I learn more about changing or cancelling my trip in the area near Fort Defiance State Park?
For more information about updating your stay near Fort Defiance State Park or cancelling it, head over to our customer service page.