The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West for 2026

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.

A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.

A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.

A swimming pool with lounge chairs, surrounded by palm trees and greenery.

1. Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

John

￥35,155

￥39,550 total

includes taxes & fees

Oct 12 - Oct 13

A pool area with lounge chairs and a table, surrounded by palm trees.

A building with a neon sign that reads "Orchid Key Inn."

A hotel room with a large bed, a nightstand, a desk, a bathroom with a shower, and a painting of a pier over water on the wall.

A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

2. Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Lisa

￥36,593

￥41,166 total

includes taxes & fees

Oct 13 - Oct 14

A large, ornate hotel with a pool, palm trees, and a view of the ocean.

A gated entrance with a blue metal gate, palm trees, and a building with a red roof in the background.

A large, two-story house with a prominent tower and a covered porch.

A grand staircase with ornate railings and a chandelier.

3. Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

yessy

￥21,996

￥44,729 total

includes taxes & fees

Oct 26 - Oct 27

A swimming pool with water splashing, surrounded by palm trees and a building in the background.

A two-story yellow house with a porch, white railings, and green shutters.

The entrance to Silver Palms Inn with a reception desk, a seating area, and a glass door.

The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.

4. Silver Palms Inn & Historic Homes

Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary

sam

￥16,911

￥29,685 total

includes taxes & fees

Oct 26 - Oct 27

A bedroom with a bed, bedside table, lamp, and a small kitchenette. There is a balcony with wicker chairs and a glass table.

A cozy cabin with a wooden interior, a bed, a TV, and a kitchenette.

A spacious living area with a wooden staircase, a ceiling fan, a TV, and a view of the beach through an open door.

A spacious living area with a gray sofa, wooden staircase, and a kitchen in the background.

5. Eden House

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

￥19,730

￥24,860 total

includes taxes & fees

Oct 13 - Oct 14

A breakfast setup with wine bottles, fruits, and pastries on a tray by a door with a view of a staircase and greenery.

A white building with a grey roof, surrounded by potted plants and a blue umbrella.

A spacious kitchen with wooden cabinets and a dining area with a round table and chairs.

A patio with sun loungers, a table with an umbrella, and potted plants.

6. The Cabana Inn Key West - Adults Only

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Donna

￥26,859

￥37,320 total

includes taxes & fees

Oct 12 - Oct 13

A hotel with a swimming pool, balconies, and a view of the sea.

A marina with jet skis docked in front of a hotel with a dock and a boat in the background.

A spacious bar area with a wooden counter and green bar stools, a seating area with a sofa and chairs, and a dining area with a table set for two.

A beach wedding setup with white chairs, a wooden arch, and lanterns.

7. Hyatt Centric Key West Resort and Spa

Historic Seaport, 1.3 km from Florida Keys National Marine Sanctuary

Jennifer

￥38,054

￥53,825 total

includes taxes & fees

Oct 26 - Oct 27

A multi-story hotel with a pink facade, multiple balconies, and a prominent 'LA CONCHA' sign.

A balcony with a sofa, a round table, and a view of the cityscape.

A beach with clear turquoise water, snorkelers, and a large building in the background.

A modern hotel entrance with a black and white striped curtain, wicker furniture, potted plants, and a sign for the Autograph Collection.

8. La Concha Key West, Autograph Collection

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

￥34,580

￥44,232 total

includes taxes & fees

Oct 11 - Oct 12

A two-story building with a porch, a brown door, and a sign for 'The Independent Inn'.

9. The Independent Inn - Formerly Heron House Court

Historic Seaport, 1.6 km from Florida Keys National Marine Sanctuary

Michael

￥20,137

￥27,996 total

includes taxes & fees

Oct 13 - Oct 14

A swimming pool with clear water, surrounded by lush greenery and palm trees.

A yellow building with a blue door and shutters, a number '302' on the wall, and a small porch area.

A bathroom with a white sink, three bottles of body lotion, and a white towel.

A covered porch with white columns and wicker furniture.

10. Tranquility Guest House

Bahama Village, 0.5 km from Florida Keys National Marine Sanctuary

￥19,663

￥36,154 total

includes taxes & fees

Oct 15 - Oct 16

A poolside area with lounge chairs, a small pool, and a white building with a balcony.

A pool area with lounge chairs, a hot tub, and a deck with a railing.

A bedroom with a bed, a ceiling fan, a window with blinds, a painting, and a nightstand with a lamp.

A white building with a sign reading "The StarCare Inn" and a "No Vacancies" sign.

11. Seascape Tropical Inn - Adult Exclusive

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Julia

￥19,738

￥30,199 total

includes taxes & fees

Oct 11 - Oct 12

A gated entrance with a gazebo, palm trees, and a brick pathway leading to a building with a red roof.

A waterfront property with a white facade, palm trees, and a street view.

A bedroom with a large bed, wooden headboard, two bedside lamps, and a floral wall art piece.

A poolside area with lounge chairs and umbrellas, a bar, and a staircase leading to a house.

12. Duval Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Arnold J

￥19,095

￥29,476 total

includes taxes & fees

Oct 14 - Oct 15

A deck with sun loungers and a railing overlooking the sea.

A poolside area with lounge chairs and umbrellas, palm trees, and a view of the sea.

A beachside hotel with rows of blue lounge chairs and white umbrellas, palm trees, and a clear blue sky.

A room with a view of the beach and ocean, a bed with a white and blue blanket, and a small table with a potted plant.

13. Southernmost Beach Resort and Guesthouses

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Krystle

￥23,101

￥37,535 total

includes taxes & fees

Oct 11 - Oct 12

A beach with a wooden pier, palm trees, and beach umbrellas.

An outdoor dining area with tables set for guests, overlooking a calm sea and a pier.

An outdoor dining area with tables and chairs, overlooking the ocean.

A resort with a pool, lounge chairs, umbrellas, palm trees, and a view of the ocean.

14. The Reach Key West, Curio Collection by Hilton

Uptown - Upper Duval, 1.4 km from Florida Keys National Marine Sanctuary

Darlene

￥28,051

￥42,216 total

includes taxes & fees

Oct 25 - Oct 26

A wooden deck with wicker furniture and a glass balustrade overlooking a beach.

A spacious lobby with green sofas, a coffee table, and a dining area.

A beach with white lounge chairs and umbrellas, a sandy shore, and a calm sea under a partly cloudy sky.

A resort with a pool leading to a beach, surrounded by palm trees and white buildings.

15. Casa Marina Key West, Curio Collection by Hilton

Casa Marina, 1.8 km from Florida Keys National Marine Sanctuary

Coni

￥34,091

￥49,011 total

includes taxes & fees

Oct 25 - Oct 26

A poolside area with lounge chairs, a staircase leading to a balcony, and a pool.

A beige sofa with two pillows, flanked by two wooden side tables with lamps and potted plants, against a white wall with a framed picture of a tree.

An outdoor patio with tables and chairs, surrounded by trees and a house.

A dining area with round tables and wicker chairs, a ceiling fan, and a bar area in the background.

16. The Southernmost Inn - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Anthony

￥18,790

￥28,242 total

includes taxes & fees

Oct 14 - Oct 15

A balcony with a view of a street, a bench, and a potted plant.

A reception desk with clocks, a Pegasus International Hotel sign, and a computer monitor.

A multi-story building with a ground-level commercial space featuring a brightly lit storefront.

A hotel lobby with a bar area, seating, and a fireplace.

17. Pegasus International Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Karla

￥22,697

￥33,533 total

includes taxes & fees

Oct 12 - Oct 13

A neatly made bed with white linens and a blue throw blanket, a bedside table with a lamp, and an air conditioning unit mounted on the wall.

A shower with white subway tiles and a black shower curtain.

A room with a wooden floor, a white door with horizontal slats, a wooden wall, and a small shelf with a black object.

A youth hostel with a white exterior, a blue awning, and a white picket fence.

18. Seashell Motel

Casa Marina, 1.5 km from Florida Keys National Marine Sanctuary

Yuliya

￥19,651

￥22,108 total

includes taxes & fees

Oct 15 - Oct 16

A covered outdoor seating area with wicker chairs and a glass table, overlooking a lush garden with palm trees and a pool.

A covered outdoor area with wicker furniture, a pool, and surrounding palm trees.

A wooden door with a fire alarm, a white door with shutters, and a patterned carpet.

A spacious living room with a large leather sofa, green armchairs, and a red and white patterned rug. There are framed botanical prints on the wall and a view into the dining area through glass doors.

19. Curry House

Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary

donald

￥14,061

￥41,594 total

includes taxes & fees

Oct 14 - Oct 15

A pool area with lounge chairs and palm trees, overlooking the ocean.

A beach view with palm trees and lounge chairs.

A bedroom with a bed, desk, chair, ceiling fan, and a view of the outdoors through a sliding door.

A beachfront hotel with multiple buildings, palm trees, and a clear view of the ocean.

20. Coconut Beach Resort Timeshare

Casa Marina, 1.5 km from Florida Keys National Marine Sanctuary

Wayne

￥217,389

￥244,562 total

includes taxes & fees

Oct 14 - Oct 15

View all properties

Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Star rating	Guest rating
Almond Tree Inn Hotel - Adults Only	10.0 Exceptional 1,006 reviews	View
Orchid Key Inn - Adults Only	9.8 Exceptional 1,004 reviews	View
Southernmost House - Adult Exclusive	9.4 Exceptional 1,000 reviews	View
Silver Palms Inn & Historic Homes	9.4 Exceptional 1,042 reviews	View
Eden House	9.0 Wonderful 1,002 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Duval House

10/10 Excellent

"The morning breakfast was fresh and the staff were friendly. Very pleasant The grounds were beautifully kept We met the landscape grounds manager and he loved what he does"

Caribbean House

10/10 Excellent

"Quiet, close (walking distance) to all the attractions in Key West!"

Southwinds Motel

10/10 Excellent

"Close to a lot of places I wanted to see. The ice cream and doughnuts bar was awesome! The was really comfortable."

Pier House Resort & Spa

8/10 Good

"Guest BEWARE, didn't think there would be a surcharge, but there was. A total of $262. and no one said anything. When we checked in and the asked for a credit card, I asked why, they said for unexpectedly occurred charges, nothing about surcharges. So PLEASE beware"

The Cabana Inn Key West - Adults Only

10/10 Excellent

"Our room was spacious and clean. We loved the uniqueness of the hotel and the proximity to all the bars and restaurants on Duvall street."

Paradise Inn Key West - Adults Only

10/10 Excellent

"The staff were friendly and helpful."

Douglas House - Adults Only

10/10 Excellent

"It’s like a little private oasis once you’re inside. Super relaxing yet close to everything."

Lighthouse Hotel - Key West Historic Inns

10/10 Excellent

"Nice hotel Clean rooms Cute pool and bar area Would stay again"

Southernmost Beach Resort and Guesthouses

10/10 Excellent

"Perfect! Great surroundings, staff & people! Convenient to get to everything!"

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)

The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.

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A wooden signpost with directional arrows pointing to various cities and their distances.

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.

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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)

You can learn about the history of Key West with a stop at Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.

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Coffee Butler Amphitheater

You can enjoy a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.

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USCGC Ingham Maritime Museum

You can spend an afternoon exploring the galleries in USCGC Ingham Maritime Museum during your trip to Key West.

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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.

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We Cycle Key West

You can search for that perfect souvenir at We Cycle Key West during your trip to Key West.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, biking, and lively festivals. If you're looking for a convenient place to stay, check out the 1487 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Florida Keys National Marine Sanctuary?

Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveler data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.

How many hotels will I be able to find near Florida Keys National Marine Sanctuary?

Expedia has 1487 hotels and other accommodations within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then you can filter by "fully refundable" to review the best options available near Florida Keys National Marine Sanctuary.

Where can I learn more about changing or cancelling my trip in the area near Florida Keys National Marine Sanctuary?

To find more details about updating your stay near Florida Keys National Marine Sanctuary or cancelling it, head over to our customer service page.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House, and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum, and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Coffee Butler Amphitheater, and Key West Film Society if you're interested in local theater.

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Find hotels near Florida Keys National Marine Sanctuary, Key West from ￥22,108

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Treat yourself

Be picky

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Our top choices for Florida Keys National Marine Sanctuary hotels

1. Almond Tree Inn Hotel - Adults Only

2. Orchid Key Inn - Adults Only

3. Southernmost House - Adult Exclusive

4. Silver Palms Inn & Historic Homes

5. Eden House

6. The Cabana Inn Key West - Adults Only

7. Hyatt Centric Key West Resort and Spa

8. La Concha Key West, Autograph Collection

9. The Independent Inn - Formerly Heron House Court

10. Tranquility Guest House

11. Seascape Tropical Inn - Adult Exclusive

12. Duval Inn

13. Southernmost Beach Resort and Guesthouses

14. The Reach Key West, Curio Collection by Hilton

15. Casa Marina Key West, Curio Collection by Hilton

16. The Southernmost Inn - Adults Only

17. Pegasus International Hotel

18. Seashell Motel

19. Curry House

20. Coconut Beach Resort Timeshare

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Duval House

Caribbean House

Southwinds Motel

Pier House Resort & Spa

The Cabana Inn Key West - Adults Only

Paradise Inn Key West - Adults Only

Douglas House - Adults Only

Lighthouse Hotel - Key West Historic Inns

Southernmost Beach Resort and Guesthouses

Other attractions near Florida Keys National Marine Sanctuary

Florida Keys Eco - Discovery Center

Fort Zachary Taylor Historic State Park

Truman Beach

Jackson Square

Coffee Butler Amphitheater

USCGC Ingham Maritime Museum

Truman Waterfront Park

We Cycle Key West

Frequently asked questions

Explore a world of travel with Expedia