Find Family Hotels in Florence, SC

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Check availability on Florence Family Hotels

Tonight
Dec 30 - Dec 31
Tomorrow
Dec 31 - Jan 1
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for Florence family-friendly hotels

Lobby
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence
2.0 star property
Florence
8.6 out of 10, Excellent, (2528)
"Great room and staff."
United States
LEE
The price is ￥9,826
￥11,005 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Howard Johnson by Wyndham Florence
Lobby sitting area
Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC

Spark by Hilton Florence North I-95, SC
2.5 star property
Florence
8.0 out of 10, Very Good, (32)
"Friendly staff and clean environment "
United States
john
The price is ￥15,220
￥17,663 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Spark by Hilton Florence North I-95, SC
Exterior
Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95
2.5 star property
Florence
9.0 out of 10, Wonderful, (827)
"Overall great experience!! Staff was very nice, hotel was very clean & such a plus that it’s dog friendly. "
United States
Paul
The price is ￥17,937
￥20,090 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Hampton Inn & Suites Florence-North-I-95
Exterior
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
2.5 star property
Florence
9.2 out of 10, Wonderful, (1006)
"Very good breakfast & convenient location"
United States
Diedre
The price is ￥17,157
￥19,215 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
Exterior
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence
3.0 star property
Florence
8.0 out of 10, Very Good, (1676)
"Staff was great, breakfast was well stocked "
United States
constance
The price is ￥14,583
￥16,334 total
includes taxes & fees
Jan 13 - Jan 14, 2026
La Quinta Inn & Suites by Wyndham Florence
Premium bedding, in-room safe, desk, iron/ironing board
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center
2.5 star property
Florence
7.8 out of 10, Good, (1262)
"Room was spotless and the staff was friendly..."
United States
Randy
The price is ￥12,283
￥13,755 total
includes taxes & fees
Jan 28 - Jan 29, 2026
Quality Inn & Suites Florence Civic Center
View from property
Fairfield Inn & Suites by Marriott Florence I-20

Fairfield Inn & Suites by Marriott Florence I-20

Fairfield Inn & Suites by Marriott Florence I-20
2.5 star property
Florence
9.0 out of 10, Wonderful, (562)
"Clean room, professional and courteous staff. "
United States
Felicia
The price is ￥17,102
￥19,154 total
includes taxes & fees
Jan 21 - Jan 22, 2026
Fairfield Inn & Suites by Marriott Florence I-20
Indoor pool
Courtyard by Marriott Florence

Courtyard by Marriott Florence

Courtyard by Marriott Florence
3.0 star property
Florence
7.8 out of 10, Good, (703)
"Very nice hotel. Clean, pleasant staff, and very well done room with comfortable bed."
United States
Kelly
The price is ￥15,172
￥16,993 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Courtyard by Marriott Florence
Exterior
Comfort Suites Florence I-95

Comfort Suites Florence I-95

Comfort Suites Florence I-95
2.5 star property
Florence
8.4 out of 10, Very Good, (1003)
"Pool was clean good breakfast "
United States
Ann
The price is ￥16,003
￥18,547 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Comfort Suites Florence I-95
Bar (on property)
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton
3.0 star property
Florence
8.8 out of 10, Excellent, (607)
"Special place. Great staff with an outstanding restaurant "
United States
John D
The price is ￥20,335
￥22,774 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Hotel Florence, Tapestry Collection by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Florence Hotel Reviews

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

10/10 Excellent
"Friendly staff, quick check in, nice lobby"
Jennifer 1-night trip
Posted 1 day ago
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG

Frequently asked questions

What's Florence like for family-friendly vacations?
The welcoming destination of Florence is a good choice if you've been considering a getaway with your kids. The entertainment, excursions, and museums are just a few things that make this an attractive vacation spot for families. Fly into Florence, SC (FLO-Florence Regional), which is located 2.3 mi (3.7 km) from the city center.
What's the best place to stay for families in Florence?
La Quinta Inn & Suites by Wyndham Florence is a hotel with free parking and free breakfast, and it's a top choice on Expedia for families. Other options for your stay with the kids include Howard Johnson by Wyndham Florence and Aloft Florence.
How many family-friendly hotels can I expect to find in Florence?
Expedia has 9 family-friendly hotels and other accommodations in Florence.
When's the best time to book a family-friendly vacation in Florence?
The hottest months are usually July and August with an average temp of 78°F, while the coldest months are January and February with an average of 50°F. Average annual precipitation for Florence is 54 inches.
What's there to see and do with your family in Florence?
While you are visiting Florence, you and the family might want to check out some interesting spots such as Dr. Eddie Floyd Tennis Center, Magnolia Mall, and Drs Bruce and Lee Foundation Library. Make sure you have lots of time for activities like War Between the States Museum and Florence Motor Speedway.
What's the best way for us to get around Florence?
If you want to explore the larger area, hop on a train at Florence Station. Florence may not have many public transit options so consider renting a car to explore more.