Find 4 Star Hotels in Texas Medical Center, TX from ￥13,632

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Check availability on Texas Medical Center 4 Star Hotels

Tonight
Dec 8 - Dec 9
Tomorrow
Dec 9 - Dec 10
This weekend
Dec 12 - Dec 14
Next weekend
Dec 19 - Dec 21

Compare Texas Medical Center 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Exterior detail
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4.0 star property
Greater Uptown
8.2 out of 10, Very Good, (3046)
"Wonderful property will be booking again"
United States
Tyanna
The price is ￥17,214
￥20,281 total
includes taxes & fees
Jan 6 - Jan 7, 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Exterior
The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4.0 star property
The Galleria
8.4 out of 10, Very Good, (1436)
"Nice hotel"
United States
Rawle
The price is ￥20,038
￥23,445 total
includes taxes & fees
Dec 20 - Dec 21
The Royal Sonesta Houston Galleria
Banquet hall
The Westin Galleria Houston

The Westin Galleria Houston

4.5 star property
The Galleria
9.0 out of 10, Wonderful, (1003)
"Excellent property. Great location next to shopping mall. "
Canada
Paul
The price is ￥24,729
￥33,831 total
includes taxes & fees
Dec 12 - Dec 13
The Westin Galleria Houston
Lobby
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4.0 star property
Downtown Houston
8.4 out of 10, Very Good, (3940)
"Hotel was beautiful, room was great for the price"
United States
Sonya
The price is ￥12,442
￥14,556 total
includes taxes & fees
Dec 26 - Dec 27
Club Quarters Hotel Downtown, Houston
Lobby
Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton

4.0 star property
Texas Medical Center
9.0 out of 10, Wonderful, (3600)
"Everything about our stay was excellent. "
United States
Clarence
The price is ￥19,082
￥22,326 total
includes taxes & fees
Dec 15 - Dec 16
Blossom Hotel Houston, Curio Collection by Hilton
Premium bedding, pillowtop beds, minibar, in-room safe
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 star property
South Central Houston
9.0 out of 10, Wonderful, (1841)
"Very nice room, great staff, excellent food & drink."
United States
Mary
Hotel Zaza Houston Museum District
View from property
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel

4.0 star property
Downtown Houston
9.2 out of 10, Wonderful, (1315)
"Good location, beautiful room and seamless checkin"
United States
kanchana
The price is ￥19,416
￥23,199 total
includes taxes & fees
Dec 17 - Dec 18
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Interior
Omni Houston Hotel

Omni Houston Hotel

4.0 star property
Greater Uptown
9.0 out of 10, Wonderful, (1011)
"Great location! "
United States
Fletcher
The price is ￥24,730
￥29,367 total
includes taxes & fees
Dec 14 - Dec 15
Omni Houston Hotel
Business center
DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza

4.0 star property
Greenway Plaza-Upper Kirby
8.4 out of 10, Very Good, (1375)
"Great service, clean room, lots of amenities. Very pleasant stay"
Canada
Andrea
The price is ￥14,034
￥16,420 total
includes taxes & fees
Dec 17 - Dec 18
DoubleTree by Hilton Hotel Houston - Greenway Plaza
Lunch, dinner, brunch served; Italian cuisine
C. Baldwin, Curio Collection by Hilton

C. Baldwin, Curio Collection by Hilton

4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (1004)
"The best hotel in Houston!"
United States
Shanola
The price is ￥22,442
￥30,375 total
includes taxes & fees
Dec 20 - Dec 21
C. Baldwin, Curio Collection by Hilton
Exterior
Hilton Americas-Houston

Hilton Americas-Houston

4.0 star property
Downtown Houston
9.4 out of 10, Exceptional, (1591)
"Hotel was very nice and clean. "
United States
Daniel
The price is ￥21,917
￥26,006 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hilton Americas-Houston
Cocktail bar
Le Meridien Houston Downtown

Le Meridien Houston Downtown

4.0 star property
Downtown Houston
8.8 out of 10, Excellent, (1009)
"Great amenities "
United States
Larry
The price is ￥23,633
￥27,651 total
includes taxes & fees
Dec 18 - Dec 19
Le Meridien Houston Downtown
City view from property
The Whitehall Houston

The Whitehall Houston

4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (1900)
"Great stay."
United States
Anita
The price is ￥17,255
￥20,189 total
includes taxes & fees
Dec 20 - Dec 21
The Whitehall Houston
Daily buffet breakfast for a fee
DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites

4.0 star property
Texas Medical Center
8.4 out of 10, Very Good, (469)
"Staff was helpful in getting me back & forth to MD Anderson Cancer Hospital. "
United States
Patricia
The price is ￥13,553
￥15,857 total
includes taxes & fees
Dec 22 - Dec 23
DoubleTree by Hilton Houston Medical Center Hotel & Suites
Sundeck
Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

4.5 star property
Texas Medical Center
8.4 out of 10, Very Good, (1730)
"Loved the room, clean, friendly staff. Would reccomend :)"
United States
Rolando
The price is ￥14,505
￥17,150 total
includes taxes & fees
Dec 21 - Dec 22
Hilton Houston Plaza/Medical Center
Exterior
The Moran CITYCENTRE

The Moran CITYCENTRE

4.0 star property
Memorial
9.0 out of 10, Wonderful, (1014)
"Great Stay "
United States
Malcolm
The price is ￥21,270
￥29,513 total
includes taxes & fees
Dec 21 - Dec 22
The Moran CITYCENTRE
Meeting facility
The Westin Oaks Houston at the Galleria

The Westin Oaks Houston at the Galleria

4.0 star property
The Galleria
9.0 out of 10, Wonderful, (1003)
"Todo excelente!"
Mexico
patricia
The price is ￥24,729
￥33,831 total
includes taxes & fees
Dec 12 - Dec 13
The Westin Oaks Houston at the Galleria
Outdoor pool, open 6:00 AM to 10:00 PM, pool umbrellas, sun loungers
Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria

4.0 star property
The Galleria
9.0 out of 10, Wonderful, (1172)
"Staff was very courteous, Vallet was super helpful and nice, and room was excellent. Hotel was beautifully decorated for holidays. "
United States
Coleen
The price is ￥19,510
￥27,550 total
includes taxes & fees
Dec 11 - Dec 12
Hyatt Regency Houston/Galleria
Reception
InterContinental Houston by IHG

InterContinental Houston by IHG

4.0 star property
Texas Medical Center
9.2 out of 10, Wonderful, (1003)
"Clean room, excellent staff, kind and respectful."
United States
DIANA
The price is ￥22,212
￥29,095 total
includes taxes & fees
Dec 18 - Dec 19
InterContinental Houston by IHG
Outdoor pool, free cabanas, pool umbrellas
The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4.0 star property
Texas Medical Center
9.2 out of 10, Wonderful, (1008)
"Clean room close to food, coffee and hospitals. "
United States
Patrick
The price is ￥21,270
￥26,476 total
includes taxes & fees
Dec 19 - Dec 20
The Westin Houston Medical Center/Museum District
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Texas Medical Center.
The Post Oak Hotel at Uptown Houston

The Post Oak Hotel at Uptown Houston

1600 West Loop South Houston TX
The price is ￥76,947 per night from Dec 25 to Dec 26
￥76,947
￥90,027 total
Dec 25 - Dec 26
includes taxes & fees
9.6/10 Exceptional! (878 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Texas Medical Center Hotel Reviews

InterContinental Houston by IHG

InterContinental Houston by IHG

10/10 Excellent
"I have not stayed in an Intercontinental hotel in a while and this hotel makes me want to search for Intercontinental first before I look at other hotels. Really wonderful at every turn. "
Jarrod 1-night trip
Posted 16 hours ago
InterContinental Houston by IHG

Frequently asked questions

What are the best 4-star hotels in Texas Medical Center?
Blossom Hotel Houston and DoubleTree by Hilton Houston Medical Center Hotel & Suites are two highly recommended picks situated in or near Texas Medical Center. Both have a 4-star rating and promise luxury comfort alongside an unbeatable traveler experience. Book a stay at the first and enjoy access to premium bedding and designer toiletries. The second has premium bedding and a swimming pool, among other amenities.
How much does it cost to stay in a 4-star hotel in Texas Medical Center?
With Expedia's handy search filters, scoring a top deal on a 4-star hotel in Texas Medical Center just got simpler. Start by entering your chosen travel dates and length of your stay. Then sort the results by price and pick the option that best matches your style and budget.

  • Search for the lowest price from ￥13,632

What's the difference between 5-star and 4-star hotels in Texas Medical Center?
Offering a welcoming guest experience and upmarket décor, 4-star hotels are a fantastic option for your Texas Medical Center getaway. These types of stays generally come with loads of handy amenities that make it easy to unpack and unwind — think large beds, bathrobes, pools and restaurants. Or enjoy even more lavishness at a 5-star hotel designed to pamper with high-end perks and amenities. Full-service health clubs, complimentary toiletries and fine dining are typically featured at these swanky properties.

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