A cityscape with a park, a river, and a large building with a red roof.

Find 4 Star Hotels in Texas Medical Center, TX from ￥19,038

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Texas Medical Center 4 Star Hotels

This weekend
Jun 26 - Jun 28
Next weekend
Jul 3 - Jul 5

Our top choices for Texas Medical Center 4-star hotels

Breakfast, lunch and dinner served

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (4,262 reviews)
"Great stay, close to Daikin park!"
United States
Anthony
The price is ￥16,272
￥19,038 total
includes taxes & fees
Jul 5 - Jul 6
Club Quarters Hotel Downtown, Houston
Terrace/patio

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center
8.4 out of 10, Very Good, (1,965 reviews)
"Great stay and clean room"
United States
Ethel
The price is ￥20,808
￥24,533 total
includes taxes & fees
Jul 5 - Jul 6
Hilton Houston Plaza/Medical Center
Staircase

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria
8.6 out of 10, Excellent, (2,041 reviews)
"Great hotel!"
United States
Pooja Krishna
The price is ￥28,873
￥33,782 total
includes taxes & fees
Jul 10 - Jul 11
The Royal Sonesta Houston Galleria
Lobby

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center
9.0 out of 10, Wonderful, (3,849 reviews)
"Great Stay!"
United States
Cairo
The price is ￥27,624
￥32,323 total
includes taxes & fees
Jul 23 - Jul 24
Blossom Hotel Houston, Curio Collection by Hilton
Exterior

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
Greater Uptown
8.4 out of 10, Very Good, (4,179 reviews)
"Stayed with my family of 4, it was spacious, clean and comfortable. Would definitely stay again."
United States
Rochelle L
The price is ￥23,595
￥27,797 total
includes taxes & fees
Jul 12 - Jul 13
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Premium bedding, pillowtop beds, minibar, in-room safe

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,005 reviews)
"Great place to stay"
United States
Gayathry
The price is ￥31,942
￥44,669 total
includes taxes & fees
Jul 11 - Jul 12
Hotel Zaza Houston Museum District
Seasonal outdoor pool, cabanas (surcharge), pool umbrellas

Grand Tuscany Hotel

Grand Tuscany Hotel
4.0 star property
Fairbanks
8.0 out of 10, Very Good, (124 reviews)
"Great stay"
United States
Britany
The price is ￥17,275
￥20,212 total
includes taxes & fees
Jul 6 - Jul 7
Grand Tuscany Hotel
Lounge

The Westin Galleria Houston

The Westin Galleria Houston
4.5 star property
The Galleria
9.0 out of 10, Wonderful, (1,007 reviews)
"We stay here regularly for dance competitions and it is always clean and well maintained. Will definitely stay there again."
United States
Jodie
The price is ￥33,421
￥44,301 total
includes taxes & fees
Jul 23 - Jul 24
The Westin Galleria Houston
Presidential Suite, 1 King Bed | Premium bedding, in-room safe, desk, iron/ironing board

DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
Greenway Plaza-Upper Kirby
8.4 out of 10, Very Good, (1,660 reviews)
"very nice property, love the green space and food was excellent at the bar"
United States
Bessy
The price is ￥17,746
￥20,761 total
includes taxes & fees
Jul 6 - Jul 7
DoubleTree by Hilton Hotel Houston - Greenway Plaza
Indoor pool, open 6 AM to 11 PM, sun loungers

Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
Downtown Houston
9.4 out of 10, Exceptional, (1,765 reviews)
"Great stay, will recommend"
United States
Cesar
The price is ￥28,069
￥33,164 total
includes taxes & fees
Jul 5 - Jul 6
Hilton Americas-Houston
3 bars/lounges, lobby lounge

Omni Houston Hotel

Omni Houston Hotel
4.0 star property
Greater Uptown
9.2 out of 10, Wonderful, (1,007 reviews)
"Great place"
United States
Gustavo
The price is ￥27,261
￥32,374 total
includes taxes & fees
Jul 10 - Jul 11
Omni Houston Hotel
Exterior

The Moran CITYCENTRE

The Moran CITYCENTRE
4.0 star property
Memorial
9.0 out of 10, Wonderful, (1,066 reviews)
"Very relaxing place."
United States
CLINTON
The Moran CITYCENTRE
City view from property

The Whitehall Houston

The Whitehall Houston
4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (2,246 reviews)
"The hotel was in the perfect location for our stay! Staff was super helpful and room was nice and clean. Would stay again."
United States
Peyton
The price is ￥25,417
￥29,737 total
includes taxes & fees
Jul 6 - Jul 7
The Whitehall Houston
View from property

Marriott Marquis Houston

Marriott Marquis Houston
4.0 star property
Downtown Houston
9.0 out of 10, Wonderful, (1,116 reviews)
"This is a great place to stay!"
United States
Alicia
The price is ￥44,680
￥53,644 total
includes taxes & fees
Jul 6 - Jul 7
Marriott Marquis Houston
55-inch flat-screen TV with cable channels, Smart TV, pay movies

The Westin Oaks Houston at the Galleria

The Westin Oaks Houston at the Galleria
4.0 star property
The Galleria
9.2 out of 10, Wonderful, (1,004 reviews)
"Staff was very friendly."
Canada
Weiming
The price is ￥29,550
￥39,713 total
includes taxes & fees
Jul 10 - Jul 11
The Westin Oaks Houston at the Galleria
Exterior

InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
Texas Medical Center
9.2 out of 10, Wonderful, (1,007 reviews)
"Was a over great place to stay"
United States
Danny
The price is ￥26,615
￥34,365 total
includes taxes & fees
Jul 6 - Jul 7
InterContinental Houston by IHG
Lobby

Thompson Houston, by Hyatt

Thompson Houston, by Hyatt
4.0 star property
Fourth Ward
9.4 out of 10, Exceptional, (284 reviews)
"Excelente"
Mexico
CAROLINA
The price is ￥41,954
￥55,976 total
includes taxes & fees
Jun 25 - Jun 26
Thompson Houston, by Hyatt
Lobby sitting area

Houston Marriott Westchase

Houston Marriott Westchase
4.0 star property
Westchase
8.4 out of 10, Very Good, (1,019 reviews)
"Nice place"
United States
WEN LONG
The price is ￥18,509
￥21,741 total
includes taxes & fees
Jul 19 - Jul 20
Houston Marriott Westchase
Egyptian cotton sheets, premium bedding, pillowtop beds, in-room safe

The Laura Hotel, Houston Downtown, Autograph Collection

The Laura Hotel, Houston Downtown, Autograph Collection
4.5 star property
Downtown Houston
9.0 out of 10, Wonderful, (1,147 reviews)
"The hotel was clean and nice. The staff was extremely helpful. Would absolutely stay there again."
United States
Quintina
The price is ￥28,873
￥38,894 total
includes taxes & fees
Jul 17 - Jul 18
The Laura Hotel, Houston Downtown, Autograph Collection
Lunch, dinner and brunch served

C. Baldwin, Curio Collection by Hilton

C. Baldwin, Curio Collection by Hilton
4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (1,059 reviews)
"I loved the room and the view, and the downstairs bar has a nice vibe, really cozy"
United States
Tristan
The price is ￥24,716
￥33,190 total
includes taxes & fees
Jul 6 - Jul 7
C. Baldwin, Curio Collection by Hilton
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Texas Medical Center.
Houston Grand Hotel - River Oaks

Houston Grand Hotel - River Oaks

1919 Briar Oaks Ln Houston TX
The price is ￥34,696 per night from Jul 6 to Jul 7
￥34,696
￥40,595 total
Jul 6 - Jul 7
includes taxes & fees
9.2/10 Wonderful! (458 reviews)
Still don't see what you're looking for?
See all properties in Texas Medical Center.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Texas Medical Center Hotel Reviews

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

10/10 Excellent
"Very convenient to Houston Methodist Hospital."
Kayla 2-night trip
Posted 1 hour ago
The Westin Houston Medical Center/Museum District

Frequently asked questions

What are the best 4-star hotels in Texas Medical Center?
Blossom Hotel Houston and DoubleTree by Hilton Houston Medical Center Hotel & Suites are two highly recommended picks situated in or near Texas Medical Center. Both have a 4-star rating and promise luxury comfort alongside an unbeatable traveler experience. Book a stay at the first and enjoy access to premium bedding and designer toiletries. The second has premium bedding and a swimming pool, among other amenities.
How much does it cost to stay in a 4-star hotel in Texas Medical Center?
With Expedia's handy search filters, scoring a top deal on a 4-star hotel in Texas Medical Center just got simpler. Start by entering your chosen travel dates and length of your stay. Then sort the results by price and pick the option that best matches your style and budget.

  • Search for the lowest price from ￥40,595

What's the difference between 5-star and 4-star hotels in Texas Medical Center?
Offering a welcoming guest experience and upmarket décor, 4-star hotels are a fantastic option for your Texas Medical Center getaway. These types of stays generally come with loads of handy amenities that make it easy to unpack and unwind — think large beds, bathrobes, pools and restaurants. Or enjoy even more lavishness at a 5-star hotel designed to pamper with high-end perks and amenities. Full-service health clubs, complimentary toiletries and fine dining are typically featured at these swanky properties.