A cityscape with a park, a river, and a large building with a red roof.

Find 4 Star Hotels in Texas Medical Center, TX from ￥17,572

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Texas Medical Center 4 Star Hotels

Our top choices for Texas Medical Center 4-star hotels

A spacious living area with a dining table, chairs, and a chandelier.

1. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,011 reviews)
"Great place!"
United States
Madiha
The price is ￥36,060
￥49,473 total
includes taxes & fees
Oct 24 - Oct 25
Hotel Zaza Houston Museum District
A dining table with white tablecloth, two plates of food, two wine glasses, and a vase with white flowers.

2. Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (4,532 reviews)
"Great stay"
Australia
Jonathon
The price is ￥15,020
￥17,572 total
includes taxes & fees
Oct 12 - Oct 13
Club Quarters Hotel Downtown, Houston
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

3. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center
8.4 out of 10, Very good, (2,196 reviews)
"Room was great, staff was helpful"
United States
Marvin
The price is ￥17,359
￥20,493 total
includes taxes & fees
Oct 18 - Oct 19
Hilton Houston Plaza/Medical Center
A high-rise hotel with a modern design, featuring a central courtyard with palm trees and a swimming pool.

4. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
Greater Uptown
8.4 out of 10, Very good, (4,570 reviews)
"The staff was very friendly and accommodating."
United States
Gena
The price is ￥16,925
￥19,941 total
includes taxes & fees
Oct 23 - Oct 24
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
A modern hotel interior with a central spiral staircase, large glass windows, and a buffet area with various food items.

5. The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria
8.8 out of 10, Excellent, (2,303 reviews)
"Enjoyed our stay"
United States
Thomas
The price is ￥20,304
￥23,757 total
includes taxes & fees
Oct 15 - Oct 16
The Royal Sonesta Houston Galleria
A modern cityscape with high-rise buildings, including a curved skyscraper with illuminated windows and a rectangular building with a grid-like facade.

6. The Whitehall Houston

The Whitehall Houston
4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (2,457 reviews)
"Great staff, great hotel"
United States
Abraham
The price is ￥20,771
￥24,303 total
includes taxes & fees
Oct 23 - Oct 24
The Whitehall Houston
A spacious lobby with plush seating, a marble coffee table, and a grand chandelier.

7. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center
9.0 out of 10, Wonderful, (3,835 reviews)
"Amazing hotel. Would stay here every time I’m in Houston"
United States
Steven
The price is ￥24,535
￥28,801 total
includes taxes & fees
Oct 25 - Oct 26
Blossom Hotel Houston, Curio Collection by Hilton
A modern bar area with multiple shelves of liquor bottles, a central bar counter, and seating with tables and chairs.

8. The Chifley Houston, Tapestry Collection by Hilton

The Chifley Houston, Tapestry Collection by Hilton
4.0 star property
The Galleria
9.2 out of 10, Wonderful, (1,393 reviews)
"Everything was great. I’ll definitely be staying here again"
United States
Silas
The price is ￥21,939
￥25,670 total
includes taxes & fees
Oct 24 - Oct 25
The Chifley Houston, Tapestry Collection by Hilton
A modern hotel with a prominent glass facade, a well-maintained lawn, and a clear sky.

9. DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
Greenway Plaza-Upper Kirby
8.4 out of 10, Very good, (1,927 reviews)
"The staff was very courteous and made our stay very welcoming ."
United States
Yvonne
The price is ￥17,359
￥20,310 total
includes taxes & fees
Oct 17 - Oct 18
DoubleTree by Hilton Hotel Houston - Greenway Plaza
A modern high-rise building with a glass facade, multiple floors, and a rooftop parking area.

10. The Laura Hotel, Houston Downtown, Autograph Collection

The Laura Hotel, Houston Downtown, Autograph Collection
4.5 star property
Downtown Houston
9.2 out of 10, Wonderful, (1,258 reviews)
"Great hotel"
United States
Charles
The price is ￥31,504
￥41,922 total
includes taxes & fees
Oct 23 - Oct 24
The Laura Hotel, Houston Downtown, Autograph Collection
A hotel entrance with a sign reading "MORAN" and a neon sign for "radiom ilano".

11. The Moran CITYCENTRE

The Moran CITYCENTRE
4.0 star property
Memorial
9.2 out of 10, Wonderful, (1,209 reviews)
"Great property and location"
United States
sophia
The price is ￥30,530
￥40,437 total
includes taxes & fees
Oct 16 - Oct 17
The Moran CITYCENTRE
A modern living room with a grey sofa, white cushions, a marble coffee table, a vase with white flowers, and a hanging light fixture.

12. Rusk House Serviced Apartments

Rusk House Serviced Apartments
4.5 star property
Downtown Houston
9.2 out of 10, Wonderful, (540 reviews)
"Love this hotel!"
United States
Lee
The price is ￥24,538
￥28,709 total
includes taxes & fees
Oct 19 - Oct 20
Rusk House Serviced Apartments
A rooftop pool area with lounge chairs and a view of a tall building at night.

13. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center
9.2 out of 10, Wonderful, (1,242 reviews)
"Great place"
United States
Matthew
The price is ￥25,433
￥31,657 total
includes taxes & fees
Oct 25 - Oct 26
The Westin Houston Medical Center/Museum District
An aerial view of a hotel with a distinctive pool area featuring a unique wavy design.

14. Marriott Marquis Houston

Marriott Marquis Houston
4.0 star property
Downtown Houston
9.0 out of 10, Wonderful, (1,324 reviews)
"Place was awesome"
United States
Krissy
The price is ￥44,960
￥57,868 total
includes taxes & fees
Oct 30 - Oct 31
Marriott Marquis Houston
A modern living room with a large flat-screen TV, comfortable seating, and a city view through large windows.

15. The Westin Galleria Houston

The Westin Galleria Houston
4.5 star property
The Galleria
9.2 out of 10, Wonderful, (1,006 reviews)
"The spot for restful accommodations, great shopping & good eating!!"
United States
Sara
The price is ￥32,802
￥43,479 total
includes taxes & fees
Oct 16 - Oct 17
The Westin Galleria Houston
A modern bar area with a central island, bar stools, and a glass display case filled with bottles.

16. Omni Houston Hotel

Omni Houston Hotel
4.0 star property
Greater Uptown
9.2 out of 10, Wonderful, (1,003 reviews)
"Great location"
United States
Thomas
The price is ￥26,756
￥31,774 total
includes taxes & fees
Oct 29 - Oct 30
Omni Houston Hotel
A rooftop pool area with lounge chairs, a fire feature, and a neon sign for "RANCH WATER".

17. Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria
4.0 star property
Greater Uptown
9.2 out of 10, Wonderful, (1,545 reviews)
"Super clean spacious rooms. Friendly staff, great beds!"
United States
Diego
The price is ￥24,696
￥29,077 total
includes taxes & fees
Nov 7 - Nov 8
Hyatt Regency Houston/Galleria
A swimming pool with a sunlit water surface and a cityscape in the background.

18. Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
Downtown Houston
9.4 out of 10, Exceptional, (1,874 reviews)
"Delicious breakfast and very clean hotel."
United States
Kalynn
The price is ￥29,727
￥35,097 total
includes taxes & fees
Oct 31 - Nov 1
Hilton Americas-Houston
An indoor swimming pool with a glass-domed structure, surrounded by blue-tinted walls and a stone-tiled floor.

19. Grand Tuscany Hotel

Grand Tuscany Hotel
4.0 star property
Fairbanks
8.4 out of 10, Very good, (372 reviews)
"I truly enjoyed my stay can’t wait to come back"
United States
Jazmyne Nicole
The price is ￥16,240
￥19,000 total
includes taxes & fees
Oct 25 - Oct 26
Grand Tuscany Hotel
A grand staircase with multiple steps, black railings, and lit candles on each step.

20. Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
Downtown Houston
9.2 out of 10, Wonderful, (1,686 reviews)
"Location and friendly staff."
United States
Hans
The price is ￥21,214
￥25,311 total
includes taxes & fees
Oct 25 - Oct 26
Magnolia Hotel Houston, A Tribute Portfolio Hotel
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Texas Medical Center.
The Post Oak Hotel at Uptown Houston

The Post Oak Hotel at Uptown Houston

1600 West Loop South Houston TX
The price is ￥88,812 per night from Oct 29 to Oct 30
￥88,812
￥103,911 total
Oct 29 - Oct 30
includes taxes & fees
Still don't see what you're looking for?
See all properties in Texas Medical Center.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Texas Medical Center Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Texas Medical Center?
Blossom Hotel Houston and DoubleTree by Hilton Houston Medical Center Hotel & Suites are two highly recommended picks situated in or near Texas Medical Center. Both have a 4-star rating and promise luxury comfort alongside an unbeatable traveler experience. Book a stay at the first and enjoy access to premium bedding and designer toiletries. The second has premium bedding and a swimming pool, among other amenities.
How much does it cost to stay in a 4-star hotel in Texas Medical Center?
With Expedia's handy search filters, scoring a top deal on a 4-star hotel in Texas Medical Center just got simpler. Start by entering your chosen travel dates and length of your stay. Then sort the results by price and pick the option that best matches your style and budget.

  • Search for the lowest price from ￥45,036

What's the difference between 5-star and 4-star hotels in Texas Medical Center?
Offering a welcoming guest experience and upmarket décor, 4-star hotels are a fantastic option for your Texas Medical Center getaway. These types of stays generally come with loads of handy amenities that make it easy to unpack and unwind — think large beds, bathrobes, pools and restaurants. Or enjoy even more lavishness at a 5-star hotel designed to pamper with high-end perks and amenities. Full-service health clubs, complimentary toiletries and fine dining are typically featured at these swanky properties.