Find 4 Star Hotels in Florida Keys from ￥41,820

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Check availability on Florida Keys 4 Star Hotels

Tonight
Dec 25 - Dec 26
Tomorrow
Dec 26 - Dec 27
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Our top choices for Florida Keys 4-star hotels

5 outdoor pools, cabanas (surcharge), pool umbrellas
Hawks Cay Resort

Hawks Cay Resort

Hawks Cay Resort
4.0 star property
Marathon
8.0 out of 10, Very Good, (1004)
"Excellent place for family vacation "
United States
Aneesah
The price is ￥36,981
￥52,501 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hawks Cay Resort
Exterior
Amara Cay Resort

Amara Cay Resort

Amara Cay Resort
4.0 star property
Matecumbe
8.8 out of 10, Excellent, (1266)
"Friendly staff and beautiful property !"
United States
ron
The price is ￥33,430
￥47,960 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Amara Cay Resort
32-inch LCD TV with satellite channels, TV, iPod dock
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
4.0 star property
Key Largo
8.6 out of 10, Excellent, (1001)
"One of the nicest hotels we have stayed at. Amazing staff, food, activities and property "
United States
Sara
The price is ￥62,529
￥78,941 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Outdoor pool, cabanas (surcharge), pool umbrellas
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1002)
"Beautiful location, great views, very clean property, room was great (great bed), friendly staff."
United States
Scott
The price is ￥53,487
￥68,771 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Playa Largo Resort & Spa, Autograph Collection
4 outdoor pools, pool umbrellas, sun loungers
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
4.0 star property
Marathon
8.8 out of 10, Excellent, (1270)
"Very nice resort. All the staff was friendly and helpful. The pool bar was great and the bartender was friendly. Our favorite place to stay in Marathon."
United States
William
The price is ￥44,627
￥56,074 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
Exterior
Islander Resort

Islander Resort

Islander Resort
4.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1003)
"The resort was perfect Everyone from checking in and during our stay could not have been nicer and helpful"
United States
Theresa
The price is ￥68,738
￥87,856 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Islander Resort
3 outdoor pools, sun loungers
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
4.0 star property
Marathon
8.8 out of 10, Excellent, (1003)
"Great resort with lots of fun things to do. Really enjoyed our stay there. Would highly recommend it."
United Kingdom
Jaskaran
The price is ￥50,384
￥66,898 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Tranquility Bay Beachfront Hotel and Resort
Outdoor pool, sun loungers
La Siesta Resort & Villas

La Siesta Resort & Villas

La Siesta Resort & Villas
4.0 star property
Matecumbe
8.8 out of 10, Excellent, (1001)
"Great stay and beautiful space"
United States
Amir
The price is ￥27,973
￥41,820 total
includes taxes & fees
Jan 8 - Jan 9, 2026
La Siesta Resort & Villas
5 outdoor pools, cabanas (surcharge), pool umbrellas
Villas At Hawks Cay Resort

Villas At Hawks Cay Resort

Villas At Hawks Cay Resort
4.0 star property
Marathon
8.4 out of 10, Very Good, (150)
"great trip. Clean, easy to get around. Good amenities for a family trip. "
United States
Dana J
Villas At Hawks Cay Resort
2 outdoor pools, open 8:00 AM to 6:00 PM, sun loungers
The Islands of Islamorada

The Islands of Islamorada

The Islands of Islamorada
4.0 star property
Matecumbe
9.8 out of 10, Exceptional, (70)
"Great for family vacation with kids. love it"
United States
Dixania
The price is ￥94,967
￥115,434 total
includes taxes & fees
Jan 5 - Jan 6, 2026
The Islands of Islamorada
Exterior
Marlin Bay Resort & Marina

Marlin Bay Resort & Marina

Marlin Bay Resort & Marina
4.0 star property
Marathon
10.0 out of 10, Exceptional, (1)
Marlin Bay Resort & Marina
Deluxe Villa | Private kitchen | Full-size fridge, microwave, oven, stovetop
The Reef at Marathon, Florida Keys

The Reef at Marathon, Florida Keys

The Reef at Marathon, Florida Keys
4.0 star property
Marathon
9.4 out of 10, Exceptional, (8)
"The Reef was a great place to stay. The Villa was wonderful. The pool was great. Staff very friendly. I highly recommend this place. "
United States
Cynthia
The Reef at Marathon, Florida Keys
Outdoor pool
The Caribbean Resort Coconut Palm North

The Caribbean Resort Coconut Palm North

The Caribbean Resort Coconut Palm North
4.0 star property
Matecumbe
The Caribbean Resort Coconut Palm North
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Florida Keys.
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82 Islamorada FL
The price is ￥45,228 per night from Jan 4 to Jan 5
￥45,228
￥62,285 total
Jan 4 - Jan 5, 2026
includes taxes & fees
9.2/10 Wonderful! (1,270 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

See all hotels in Florida Keys
Higgs Beach showing a sandy beach and tropical scenes as well as a large group of people

Top Florida Keys Hotel Reviews

Amara Cay Resort

Amara Cay Resort

10/10 Excellent
"Clean rooms! Great resort , fun activities , very nice and quiet area , made my anniversary with my girlfriend very special! "
Nicolas 1-night trip
Posted 4 days ago
Amara Cay Resort

Frequently asked questions

What are the best 4-star hotels in Florida Keys?
You'll discover a variety of 4-star hotels in Florida Keys, including in Key Largo. Playa Largo Resort & Spa, Autograph Collection is a customer favorite in this city that offers a tennis court and a sauna. Another stay that rates highly with travelers is Bakers Cay Resort Key Largo, Curio Collection by Hilton. Dining romance packages and private picnic options help make it their preferred choice.
How much does it cost to stay in a 4-star hotel in Florida Keys?
To find a 4-star hotel in Florida Keys that fits your budget, take advantage of Expedia's handy search filters. Take a look at the availability during your vacation dates and use our pricing filter to set your maximum rate. You can also sort your results by the most affordable retreat first.

  • Search for the lowest price from ￥62,285

What's the difference between 5-star and 4-star hotels in Florida Keys?
Offering a welcoming traveler experience and upmarket décor, 4-star hotels are an excellent option for your Florida Keys getaway. These types of accommodations generally feature loads of useful amenities that make it easy to unpack and relax — think pillowtop mattresses, pools and restaurants. Or live the high life at a 5-star hotel designed to spoil you with high-end perks and amenities. Concierge assistance, premium toiletries and fine dining are typically included at these deluxe properties.