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Top Romantic Southeast Minnesota Hotels

Alexander Mansion Bed and Breakfast

274 East Broadway Winona MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic bed & breakfast, featuring a garden and a terrace for couples to enjoy.

9.8/10 Exceptional! (519 reviews)

"This was an amazing experience! Such a beautiful mansion and the host was so pleasant and made you feel special and welcomed. Breakfast was incredible!!!! I will stay here again and tell my friends about this place!"

Reviewed on Jun 27, 2026

St James Hotel, a Historic Hotel of America

406 Main St. Red Wing MN

2 hours drive from Mayo Clinic

If you and your special someone are ready for a getaway, you're sure to love the spa and garden at this historic hotel. You'll also appreciate the luxury bedding, ...

9.2/10 Wonderful! (1,004 reviews)

Couples like: full-service spa, bar

Travelers say...

"We loved everything about this hotel, the rooms, all the special surprise rooms and the restaurant. We are already planning our next visit!"

Reviewed on Jul 1, 2026

AmericInn by Wyndham Austin

1700 8th St NW Austin MN

2 hours drive from Mayo Clinic

Enjoy a stay at this romantic hotel, featuring a hot tub and a lobby fireplace for couples to enjoy.

8.8/10 Excellent! (762 reviews)

"We had a very nice stay with our grand daughter. Walking distance to Perkins restaurant for supper and a nice hot continental breakfast in the morning before hitting the road."

Reviewed on Jul 1, 2026

See all 917 properties in Southeast Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.