Southwest Houston Luxury Vacations 2026

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Top Luxury Southwest Houston Hotels

Hotel Granduca Houston

1080 Uptown Park Blvd Houston TX

9 min drive from MD Anderson Cancer Center

Be treated to a luxury stay at Hotel Granduca Houston, where you can enjoy amenities like Champagne service, massage services, and more. Notable amenities include ...

9.4/10 Exceptional! (1,000 reviews)

"Granduca por siempre el mejor hotel, su personal amable,bonita localización y muy tranquila la zona, ya quiero volver 😍"

Reviewed on Aug 24, 2026

Houston Grand Hotel - River Oaks

1919 Briar Oaks Ln Houston TX

7 min drive from MD Anderson Cancer Center

Treat yourself to some luxurious accommodations at Houston Grand Hotel - River Oaks, where you can enjoy amenities like massage services, 24-hour room service, ...

JW Marriott Houston by the Galleria

5150 Westheimer Rd Houston TX

6 min drive from MD Anderson Cancer Center

Discover luxurious lodging at JW Marriott Houston by the Galleria, where you can enjoy amenities like 24-hour room service, pillowtop beds, and more. Deluxe ...

See all 1,334 properties in Southwest Houston

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.