Eastern Tennessee Luxury Vacations 2026

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Top Luxury Eastern Tennessee Hotels

Carnegie Hotel & Spa

1216 W State Of Franklin Rd Johnson City TN

2 hours drive from Great Smoky Mountains National Park

Treat yourself to upscale accommodations at Carnegie Hotel & Spa, where you'll enjoy amenities like premium channels and more. Notable amenities include a spa, ...

9.8/10 Exceptional! (1,437 reviews)

"Absolutely beautiful hotel - wonderfully decorated with many amazing, historic pieces - a real gem in a great little city"

Reviewed on Aug 15, 2026

THE TENNESSEAN Hotel

531 Henley Street Knoxville TN

55 min drive from Great Smoky Mountains National Park

Treat yourself to a luxury stay at THE TENNESSEAN Hotel, where you can enjoy amenities like pillowtop beds, designer toiletries, and more. The restaurant, fitness ...

The Read House Hotel

107 West Martin Luther King Blvd Chattanooga TN

4 hours drive from Great Smoky Mountains National Park

Go for a luxurious stay at The Read House Hotel, where you can enjoy amenities like Champagne service, plush bedding, and more. The indoor pool, restaurant, ...

9.6/10 Exceptional! (2,590 reviews)

"It was as good as I'd hoped. If you want to step back in time a bit, enjoy a feeling of history this is it. Disappointed that the pool was closed, not something mentioned at the time of booking. We upgraded to a larger room, which probably wasn't entirely necessary - it was very spacious, though. ..."

Reviewed on Aug 18, 2026

See all 27,273 properties in Eastern Tennessee

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.