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Top Luxury Northeast Florida Hotels

Ponte Vedra Inn & Club

200 Ponte Vedra Blvd Ponte Vedra Beach FL

6 min drive from Mayo Clinic Florida

Treat yourself to some sumptuous lodging at Ponte Vedra Inn & Club, where you'll find deep soaking bathtubs and premium bedding. Deluxe amenities at this hotel ...

9.4/10 Exceptional! (815 reviews)

Amazing. Loved it

Reviewed on Jan 12, 2026

One Ocean Resort and Spa

1 Ocean Blvd Atlantic Beach FL

11 min drive from Mayo Clinic Florida

One Ocean Resort and Spa is one of the Atlantic Beach luxury 4.5-star beach properties where you can pamper yourself with pillowtop beds, designer toiletries, ...

8.8/10 Excellent! (1,003 reviews)

Great hotel!!…. Beautiful room overlooking the ocean!!!

Reviewed on Dec 8, 2025

The Ritz-Carlton, Amelia Island

4750 Amelia Island Pkwy Fernandina Beach FL

55 min drive from Mayo Clinic Florida

Treat yourself to some luxurious accommodations at The Ritz-Carlton, Amelia Island, where you can enjoy amenities like massage services, 24-hour room service, ...

9.2/10 Wonderful! (376 reviews)

Fantastic

Reviewed on Nov 28, 2025

See all 11,900 properties in Northeast Florida

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.