Photo by Nikki Benson

Plan, book, travel with confidence
Better together
Save up to ￥45,448 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Honeymoon Eastern Piedmont Hotels

The Mayton

301 S Academy St Cary NC

37 min drive from Duke University

Book a stay at this boutique hotel in Cary. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular ...

9.4/10 Exceptional! (723 reviews)

The Mayton is niche hotel more along the lines of a bed and breakfast. The staff members were phenomenal! I will return.

Reviewed on Jan 2, 2026

The Umstead Hotel and Spa

100 Woodland Pond Dr Cary NC

29 min drive from Duke University

Book a stay at this luxury resort in Cary. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions ...

9.4/10 Exceptional! (717 reviews)

Always a great visit!

Reviewed on Jan 4, 2026

21c Museum Hotel Durham

111 North Corcoran Street Durham NC

10 min walk from Duke University

Stay at this hotel in Durham. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff in our reviews. Popular attractions ...

8.2/10 Very Good! (1,005 reviews)

This hotel is our favorite pet-friendly hotel in downtown Durham. During this last visit, I had inadvertently double booked myself a room directly with the hotel and on Expedia. The check-in host was so kind to cancel the room booked directly with the hotel without penalties. I certainly was not ...

Reviewed on Jan 4, 2026

See all 4,681 properties in Eastern Piedmont

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.