Wykoff Vacation Rentals

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Check prices for these dates

In two weeks
Dec 26 - Dec 28
In two months
Feb 6 - Feb 8
In three months
Mar 6 - Mar 8
In four months
Apr 3 - Apr 5

Vacation Rentals in Wykoff

Terrace/patio
The Berkman

Aparthotel in Folwell

3.0 star property
9.6 out of 10, Exceptional, (367)
"Perfect location for visit to hospital. "
United States
Sharon
The price is ￥25,988
￥30,218 total
includes taxes & fees
Dec 19 - Dec 20
The Berkman
Fridge, microwave, oven, stovetop
Broadway Plaza, Trademark Collection by Wyndham

Apartment in Downtown Rochester

3.0 star property
9.2 out of 10, Wonderful, (167)
"Great staff, clean room, spacious kitchen and living room."
United States
silvia
The price is ￥24,464
￥28,165 total
includes taxes & fees
Dec 24 - Dec 25
Broadway Plaza, Trademark Collection by Wyndham
Exterior
RUSTIC CABIN IN THE WOODS, 5 MIN TO ROCHESTER

Cabin in Rochester

8.0 out of 10, Very Good, (4)
"This was a quiet little getaway spot with activities to do on the property. I would definitely book this again. "
United States
Rebecca
RUSTIC CABIN IN THE WOODS, 5 MIN TO ROCHESTER
Exterior
Valley Cabin

Cabin in Spring Valley

9.2 out of 10, Wonderful, (7)
"Great property with plenty of outdoor activities. Had fun fishing the stream and exploring the area. Dan is a great host and I will be visiting again."
United States
JAKE I.
The price is ￥8,388
￥19,682 total
includes taxes & fees
Dec 9 - Dec 10
Valley Cabin
Interior
SUNNY 3BD, 2BA…ONLY BLOCKS FROM MAYO

Vacation Home in East Side Pioneers

9.4 out of 10, Exceptional, (3)
"The house was stocked with everything we needed for a girls weekend! Close to downtown too. The owner was also quick to respond to the couple questions we had. Cute house and would recommend!"
United States
Caitlin F.
SUNNY 3BD, 2BA…ONLY BLOCKS FROM MAYO
Exterior detail
Root River Valley Cabin ~ Lanesboro, MN

Cabin in Lanesboro

10.0 out of 10, Exceptional, (335)
"beautiful place! highly recommend for your quiet and relaxing vacation"
United States
Tia N.
Root River Valley Cabin ~ Lanesboro, MN
Bar (on property)
Large and Rare 1-Bedroom Retreat with Gym, Bar, Pool & More –Pet-FriendlyOptions

Apartment in Rochester

2.0 star property
The price is ￥20,038
￥26,647 total
includes taxes & fees
Dec 9 - Dec 10
Large and Rare 1-Bedroom Retreat with Gym, Bar, Pool & More –Pet-FriendlyOptions
Interior
Charming 2-bedroom apartment in delightful Rochester with WiFi, AC

Apartment in Meadow Park

10.0 out of 10, Exceptional, (1)
"Quiet, clean and in a friendly neighborhood. Staying there took some of the stress out of my Mayo Clinic visits. I always worry about my follow-up visits, but a good quiet place to stay helps me let that go."
United States
Maria L E.
The price is ￥14,756
￥31,249 total
includes taxes & fees
Dec 9 - Dec 10
Charming 2-bedroom apartment in delightful Rochester with WiFi, AC
Fridge, microwave, oven, stovetop
Mayo Discount Available- 2Bedroom Close to Mayo

Apartment in Northrup

8.0 out of 10, Very Good, (24)
"My sister and I needed a place to rest our heads after a celebration of life for a dear friend I slept well Thanks"
United States
Kim L.
Mayo Discount Available- 2Bedroom Close to Mayo
Property grounds
Cozy house / small town living. Attractions include trout capital of Minnesota

Vacation Home in Preston

5.8 out of 10, (14)
"Good location to the venue we were at for a wedding. The house needs a good cleaning. Would be a better experience for your guests. "
United States
Kimberly H.
The price is ￥14,539
￥27,453 total
includes taxes & fees
Dec 9 - Dec 10
Cozy house / small town living. Attractions include trout capital of Minnesota
Fridge, microwave, oven, stovetop
Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom

Vacation Home in Rochester

10.0 out of 10, Exceptional, (72)
"very comfortable, clean and convenient to downtown"
United States
Jeanette H.
Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom
Microwave, oven, stovetop, dishwasher
Discounted Charming 2-bedroom house in Rochester

Vacation Home in East Side Pioneers

8.6 out of 10, Excellent, (11)
"Great stay for a quick stop in Rochester. Clean, quiet neighborhood."
United States
Jill S.
The price is ￥11,650
￥31,832 total
includes taxes & fees
Dec 20 - Dec 21
Discounted Charming 2-bedroom house in Rochester
2 bedrooms, travel crib, free WiFi, bed sheets
Heritage hideaway-Secluded Log Cabin

Cabin in Chatfield

10.0 out of 10, Exceptional, (406)
"We enjoyed our stay and loved the country location and privacy!!"
United States
David D.
Heritage hideaway-Secluded Log Cabin
Outdoor dining
Century Cottage-PERFECT for Mayo & downtown visitors!

Vacation Home in Northrup

10.0 out of 10, Exceptional, (132)
"Very cozy & appreciated the extra touches. "
United States
Jenna F.
Century Cottage-PERFECT for Mayo & downtown visitors!
Fridge, microwave, oven, stovetop
Single Level Living with Comfortable Recliners

Vacation Home in Northrup

10.0 out of 10, Exceptional, (42)
"Very nice house! We had a comfortable stay and the host was excellent. Highly recommend. "
United States
Paul M.
Single Level Living with Comfortable Recliners
Dining
Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!

Apartment in Rochester

9.6 out of 10, Exceptional, (22)
"Great location "
United States
Peary S.
The price is ￥9,320
￥30,044 total
includes taxes & fees
Dec 13 - Dec 14
Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!
Fridge, microwave, oven, stovetop
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.

Vacation Home in Kutzky Park

10.0 out of 10, Exceptional, (106)
"We would stay here again."
United States
J S.
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.
Outdoor dining
Entertainment for the whole family. Sleeps up to 10.

Vacation Home in Rochester

9.8 out of 10, Exceptional, (16)
"Open space great for family. Great communication and location. Nice quiet neighborhood. Would definitely stay again."
United States
Toni Y.
Entertainment for the whole family. Sleeps up to 10.
Interior
Quiet 3 BDR Home- private sauna & skyline view- close to downtown & Mayo Clinic

Vacation Home in Rochester

10.0 out of 10, Exceptional, (1)
"This was a fantastic experience, far better than anticipated! Only a couple of comments: this high tech house was a little over the head of my crew and a guidebook to show us how to use all those remotes would have been most welcome. And one of my folks was looking for a can opener… We had a lovely time and the next convention we have in Rochester I will book here again without hesitation! "
United States
Patricia B.
The price is ￥58,870
￥77,432 total
includes taxes & fees
Dec 9 - Dec 10
Quiet 3 BDR Home- private sauna & skyline view- close to downtown & Mayo Clinic
Interior
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!

Vacation Home in East Side Pioneers

9.0 out of 10, Wonderful, (19)
"Nicely updated, very clean. Great location. They do allow pets, however it does not have a fenced yard. It is a duplex."
United States
Chris P.
The price is ￥8,232
￥32,905 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Wykoff Hotel Reviews

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent
"Great location. Friendly staff. Easy access to Mayo Clinic’s via shuttle. Rooms were comfortable and spacious. "
Jill 3-night trip
Posted 2 days ago
Hyatt House Rochester/Mayo Clinic Area

Find out more about Wykoff

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Frequently asked questions

Can I find a vacation rental in Wykoff?

Yes, we offer vacation rentals close to well known sights in Wykoff, or you can select a more secluded option if you're looking for relaxation. Wykoff is known for its museums.

What are some of the best vacation home rentals in Wykoff?

SUNNY 3BD, 2BA…ONLY BLOCKS FROM MAYO: This vacation home rental outside of Wykoff is equipped with a garden, air-conditioning, and laundry facilities to help you feel comfortable during your stay.

What’s there to see and do in Wykoff?

Enjoy the area's cultural attractions such as Ed's Museum, or get outdoors into nature at a spot like Forestville Mystery Cave State Park. In the larger area, you’ll find Four Daughters Vineyard & Winery and Deer Creek Speedway.

What’s a vacation rental in Wykoff like?

Vacation rentals are privately owned properties you can book for a few weeks or just a few days in Wykoff. Vacation rentals offer amenities like kitchens and laundry facilities so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can offer a sense of privacy away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also find more space in a vacation rental than in a hotel, which makes a vacation rental an attractive choice for a family trip or a small group gathering.