Find hotels near St. Louis Science Center, St. Louis from ￥13,380

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Compare 1,432 hotels close to St. Louis Science Center with room rates, reviews, and availability. Most hotels are fully refundable.

Exterior
Hampton Inn & Suites St. Louis at Forest Park

Hampton Inn & Suites St. Louis at Forest Park

2.5 star property
Dogtown, 1 km from St. Louis Science Center
9.4 out of 10, Exceptional, (1000)
"What a great stay! The pool area was clean, stocked with full sized towels. The room was clean and fresh. Waffles- need I say more about breakfast. The staff was great, smiling and very helpful"
United States
Katy
The price is ￥17,298
￥20,399 total
includes taxes & fees
Dec 15 - Dec 16
Hampton Inn & Suites St. Louis at Forest Park
Lobby
Drury Inn & Suites St. Louis Forest Park

Drury Inn & Suites St. Louis Forest Park

3.0 star property
2 km from St. Louis Science Center
9.4 out of 10, Exceptional, (1000)
"Very clean room and great breakfast/dinner and snacks options. "
United States
Megan
The price is ￥17,888
￥20,915 total
includes taxes & fees
Dec 15 - Dec 16
Drury Inn & Suites St. Louis Forest Park
Seasonal outdoor pool
The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

4.5 star property
Central West End, 1.8 km from St. Louis Science Center
9.0 out of 10, Wonderful, (1007)
"Clean room and staff was great. "
United States
Ronnell
The price is ￥24,767
￥33,801 total
includes taxes & fees
Dec 14 - Dec 15
The Royal Sonesta Chase Park Plaza St. Louis
Lobby
AC Hotel St. Louis Central West End

AC Hotel St. Louis Central West End

4.0 star property
Central West End, 1.8 km from St. Louis Science Center
9.0 out of 10, Wonderful, (680)
"Great staff. Rooms were super clean. 10/10 will stay here again"
United States
Jacob
The price is ￥19,783
￥23,330 total
includes taxes & fees
Dec 26 - Dec 27
AC Hotel St. Louis Central West End
Dining room
Home2 Suites by Hilton St. Louis/Forest Park

Home2 Suites by Hilton St. Louis/Forest Park

3.0 star property
The Grove, 0.9 km from St. Louis Science Center
8.6 out of 10, Excellent, (1001)
"Nice hotel. Very nice breakfast"
United States
Amir
The price is ￥18,149
￥21,223 total
includes taxes & fees
Dec 14 - Dec 15
Home2 Suites by Hilton St. Louis/Forest Park
Courtyard
Element St. Louis Midtown

Element St. Louis Midtown

3.0 star property
Midtown, 2.7 km from St. Louis Science Center
9.0 out of 10, Wonderful, (638)
"Location and amenities"
Canada
Muthu Kumar
The price is ￥21,024
￥24,584 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Element St. Louis Midtown
Property amenity
Aloft St. Louis Cortex

Aloft St. Louis Cortex

3.0 star property
Central West End, 1.8 km from St. Louis Science Center
8.6 out of 10, Excellent, (819)
"Staff at the reception were very kind and friendly, made check in and out effortlessly "
United States
Elizabeth
The price is ￥17,718
￥20,718 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Aloft St. Louis Cortex
In-room safe, desk, blackout drapes, iron/ironing board
DoubleTree by Hilton St. Louis Forest Park

DoubleTree by Hilton St. Louis Forest Park

4.0 star property
Central West End, 1.3 km from St. Louis Science Center
8.2 out of 10, Very Good, (1001)
"Great room "
United States
Jessica
The price is ￥18,521
￥21,842 total
includes taxes & fees
Dec 26 - Dec 27
DoubleTree by Hilton St. Louis Forest Park
Restaurant
Hotel Indigo St Louis - Central West End by IHG

Hotel Indigo St Louis - Central West End by IHG

3.5 star property
Central West End, 1.7 km from St. Louis Science Center
8.2 out of 10, Very Good, (1000)
"Very friendly staff. Clean modern hotel room with comfortable bed and spacious shower! "
United States
Courtney
The price is ￥15,452
￥19,932 total
includes taxes & fees
Dec 21 - Dec 22
Hotel Indigo St Louis - Central West End by IHG
Terrace/patio
The West End

The West End

2.0 star property
Central West End, 2.3 km from St. Louis Science Center
8.4 out of 10, Very Good, (400)
"Friendly staff, great rooms; and I love the north brew coffee place were the VIP access coffee is redeemed "
United States
Miguel
The price is ￥14,420
￥19,818 total
includes taxes & fees
Dec 8 - Dec 9
The West End
Comfort Apartment | Individually decorated, individually furnished, desk, laptop workspace
White House at Grand Central

White House at Grand Central

4.0 star property
3 km from St. Louis Science Center
8.6 out of 10, Excellent, (124)
"Very clean and very friendly people "
United States
Mary
The price is ￥11,963
￥24,006 total
includes taxes & fees
Dec 9 - Dec 10
White House at Grand Central
Lobby sitting area
Forest Park Hotel by MDR

Forest Park Hotel by MDR

3.0 star property
The Hill, 1.9 km from St. Louis Science Center
7.6 out of 10, Good, (1253)
"location attentive staff large king room"
United States
Stephen
The price is ￥12,320
￥15,132 total
includes taxes & fees
Dec 7 - Dec 8
Forest Park Hotel by MDR
(Lil Dynasty) No Private Bathroom | Premium bedding, iron/ironing board, free WiFi, bed sheets
Central West End B&B

Central West End B&B

3.5 star property
Central West End, 3 km from St. Louis Science Center
7.8 out of 10, Good, (53)
"Really enjoyed the comfort. I would recommend this place to anyone. Very nice breakfast also!!! "
United States
Stacee
The price is ￥23,849
￥30,164 total
includes taxes & fees
Dec 7 - Dec 8
Central West End B&B
Lobby
Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 

Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 

2.5 star property
The Hill, 1.8 km from St. Louis Science Center
5.8 out of 10, (1001)
"Staff was very pleasant and courteous. Definitely outdated facility. New bath tubs would really help. Beds were clean and comfortable. "
United States
Cheryl
The price is ￥11,443
￥13,380 total
includes taxes & fees
Dec 4 - Dec 5
Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 
Front of property
Grand Center Inn

Grand Center Inn

3.0 star property
3.5 km from St. Louis Science Center
9.4 out of 10, Exceptional, (68)
"Great place"
United States
Nguyet
The price is ￥23,143
￥27,292 total
includes taxes & fees
Dec 4 - Dec 5
Grand Center Inn
Pub
The Knight Center at Washington University

The Knight Center at Washington University

2.5 star property
4.3 km from St. Louis Science Center
9.4 out of 10, Exceptional, (437)
"The hotel is beautiful and the staff is very helpful and kind. "
United States
Beth
The price is ￥18,173
￥20,897 total
includes taxes & fees
Dec 14 - Dec 15
The Knight Center at Washington University
Exterior
Moonrise Hotel

Moonrise Hotel

4.0 star property
3.8 km from St. Louis Science Center
9.0 out of 10, Wonderful, (1911)
"This spot is our absolute favorite when visiting StL and stay every chance we get. The surrounding area is amazing and vibrant, the hotel is extremely friendly and inviting and the rooms are great and rich with city history! Can’t wait to get back. "
United States
Brian
The price is ￥19,590
￥23,299 total
includes taxes & fees
Dec 29 - Dec 30
Moonrise Hotel
Terrace/patio
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4.0 star property
3.7 km from St. Louis Science Center
8.8 out of 10, Excellent, (1030)
"This was a wonderful first experience at a beautiful hotel with such friendly staff. We will definitely stay here again!"
United States
Alexis
The price is ￥14,927
￥17,603 total
includes taxes & fees
Dec 27 - Dec 28
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Terrace/patio
Courtyard by Marriott St. Louis Brentwood

Courtyard by Marriott St. Louis Brentwood

3.0 star property
5.5 km from St. Louis Science Center
9.4 out of 10, Exceptional, (830)
"Perfect stay"
United States
Laurie
The price is ￥15,757
￥19,330 total
includes taxes & fees
Dec 14 - Dec 15
Courtyard by Marriott St. Louis Brentwood
Indoor pool
Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

3.0 star property
Downtown West, 5.3 km from St. Louis Science Center
9.4 out of 10, Exceptional, (1302)
"Great location and staff are friendly. "
United States
GARY
The price is ￥18,510
￥22,013 total
includes taxes & fees
Dec 15 - Dec 16
Drury Inn & Suites St. Louis Union Station
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Louis Science Center Hotel Reviews

Drury Inn & Suites St. Louis Forest Park

Drury Inn & Suites St. Louis Forest Park

10/10 Excellent
"Very clean room and great breakfast/dinner and snacks options. "
Megan 2-night trip
Posted 1 day ago
Drury Inn & Suites St. Louis Forest Park

Hotels near other St. Louis Science Center attractions

Forest Park

Jewel Box

Made of stacked glass in a restored art deco style, this glass house from the 1930s continues to flourish with tropical trees, hanging plants and a large fountain.
See properties
Grand Basin looking from top of Art Hill in Forest Park, St. Louis, Missouri

Forest Park

4.6/5 (2,094 reviews)
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
See properties

Frequently asked questions

What's the area like around St. Louis Science Center?
St. Louis Science Center is located in a welcoming area of St. Louis known for its picturesque gardens and sporting events. If you're looking for a convenient place to stay, check out the 68 hotels and other accommodations you'll find within a mile.
Where is the best place to stay near St. Louis Science Center?
DoubleTree by Hilton St. Louis Forest Park is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and a fitness center. It's located just a short 0.8 mi (1.3 km) from St. Louis Science Center. Other good options within a short distance include Hampton Inn & Suites St. Louis at Forest Park and Home2 Suites by Hilton St. Louis/Forest Park.
How many hotels will I be able to find near St. Louis Science Center?
Expedia has 68 hotels and other accommodations within a mile from St. Louis Science Center.
If I need to cancel the hotel reservation for my stay near St. Louis Science Center, will I receive a refund?
Yes, the majority of hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you have a reservation that's non-refundable, you might still have the option to cancel and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then use the filter option "fully refundable" to get the best options available near St. Louis Science Center.
Where can I learn more about changing or cancelling my trip in the area near St. Louis Science Center?
To access more information about changing or cancelling your stay near St. Louis Science Center, go to https://www.expedia.com/service/.
What can I see and do near St. Louis Science Center?
Cathedral Basilica of St. Louis, St. Louis Art Museum, and City Museum feature captivating exhibits. St. Louis Union Station, Sheldon Concert Hall, and Cherokee Street are monuments to see when you're exploring the area around St. Louis Science Center. You can check out the local talent at The Muny Theater, Fox Theater, and St. Louis Symphony Orchestra.

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