Penrose, MO
St. Louis
Popular places to visit
St. Louis Union Station
You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
Enterprise Center
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.
St. Louis Zoo
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Dome at America’s Center
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and great live music.
Things to do
St Louis Self-Guided Driving and Walking Audio Tour
St. Louis Premium Small Group Tour With Arch & River Cruise
St. Louis Ghost Tour: Sinister Sins & Shadows
Downtown St. Louis Smartphone Guided Audio Walking Tour App
Private Tour of St. Louis's Iconic BBQ Joints & Breweries
Penrose Hotel Deals
21C Museum Hotel St Louis
Pleasant staff
Reviewed on Feb 17, 2026
Clayton Plaza Hotel & Extended Stay
For the price you really can't ask for much more. Good breakfast, clean rooms, great showers, friendly staff. My only small criticisms are that there i
Reviewed on Feb 17, 2026
Pear Tree Inn St. Louis Airport
We felt very welcome when we arrived and were invited to some popcorn and soda as an evening snack. Our room was spotless and comfortable. The breakfast was delicious, hot, and a terrific way to begin our day of travel.
Reviewed on Feb 17, 2026
Drury Plaza Hotel St. Louis at the Arch
The room was spotless and staff were outstanding. This is our first stay at a Drury Hotel and we will now seek them out when traveling.
Reviewed on Feb 16, 2026
Hyatt Regency St. Louis at The Arch
Love the view, spacious and clean room.
Reviewed on Feb 15, 2026
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Everything was good
Reviewed on Feb 16, 2026
Other neighborhoods around Penrose
Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
Midtown
While you're in Midtown, take in top sights like Chaifetz Arena and jump on the metro at Grand Station to see more of the city.
The Grove
The Grove might not have many top sights, but St. Louis Science Center and Missouri Botanical Gardens and Arboretum are two attractions nearby that you can check out.
Downtown West
If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.
The Gate
While there might not be top attractions in The Gate, you can explore the larger area and discover places like St. Louis Union Station and Busch Stadium.
Lafayette Square
The restaurants and shopping are a few reasons travelers visit Lafayette Square. Though there aren't many top sights in the neighborhood, you can visit St. Louis Union Station and Busch Stadium, a few notable attractions nearby.
