Photo by Michael Schuier

Find Business Hotels in Southeast Iowa

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Iowa Business Hotels

Tonight
Dec 29 - Dec 30
Tomorrow
Dec 30 - Dec 31
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for Southeast Iowa business-friendly hotels

Free daily on-the-go breakfast
AmericInn by Wyndham Mount Pleasant

AmericInn by Wyndham Mount Pleasant

AmericInn by Wyndham Mount Pleasant
2.0 star property
Mount Pleasant
8.4 out of 10, Very Good, (540)
"Polite staff and very comfortable bed"
United States
Stasia
The price is ￥11,845
￥13,268 total
includes taxes & fees
Jan 11 - Jan 12, 2026
AmericInn by Wyndham Mount Pleasant
Terrace/patio
Cobblestone Inn & Suites - Fort Madison

Cobblestone Inn & Suites - Fort Madison

Cobblestone Inn & Suites - Fort Madison
2.5 star property
Fort Madison
9.4 out of 10, Exceptional, (649)
"Really nice hotel, especially when it's below zero and snowing. "
United States
David
The price is ￥10,395
￥11,643 total
includes taxes & fees
Dec 30 - Dec 31
Cobblestone Inn & Suites - Fort Madison
Exterior
Best Western Mt. Pleasant Inn

Best Western Mt. Pleasant Inn

Best Western Mt. Pleasant Inn
2.5 star property
Mount Pleasant
8.2 out of 10, Very Good, (780)
"Very friendly. "
United States
Barry
The price is ￥11,312
￥12,670 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Best Western Mt. Pleasant Inn
Free daily buffet breakfast
Hampton Inn Keokuk

Hampton Inn Keokuk

Hampton Inn Keokuk
2.5 star property
Keokuk
8.8 out of 10, Excellent, (642)
"Very good stay. I’ll definitely stay there again "
United States
Tammy
The price is ￥15,278
￥17,110 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Hampton Inn Keokuk
Suite, 1 King Bed with Sofa bed, Non Smoking | In-room safe, desk, iron/ironing board, free cribs/infant beds
Quality Inn & Suites Keokuk North

Quality Inn & Suites Keokuk North

Quality Inn & Suites Keokuk North
2.5 star property
Keokuk
8.4 out of 10, Very Good, (752)
"Decent room. Good breakfast. "
United States
Matthew
The price is ￥12,563
￥14,070 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Quality Inn & Suites Keokuk North
Double Room, 2 Double Beds | Pillowtop beds, desk, blackout drapes, iron/ironing board
Super 8 by Wyndham Mt Pleasant

Super 8 by Wyndham Mt Pleasant

Super 8 by Wyndham Mt Pleasant
2.0 star property
Mount Pleasant
8.2 out of 10, Very Good, (842)
"Good stay , no issues "
United States
John
The price is ￥10,114
￥11,327 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Super 8 by Wyndham Mt Pleasant
Exterior
Hampton Inn & Suites Burlington

Hampton Inn & Suites Burlington

Hampton Inn & Suites Burlington
2.5 star property
Burlington
9.6 out of 10, Exceptional, (311)
"Clean room, nice staff "
United States
Michael
The price is ￥20,414
￥24,326 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn & Suites Burlington
Front of property - evening/night
Fairfield Inn & Suites by Marriott Burlington

Fairfield Inn & Suites by Marriott Burlington

Fairfield Inn & Suites by Marriott Burlington
2.5 star property
Burlington
8.4 out of 10, Very Good, (295)
"It was quiet & they gave us water, when we checked in, was hot out, so that was so nice!"
United States
Loren
The price is ￥19,102
￥21,961 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Fairfield Inn & Suites by Marriott Burlington
Reception
Quality Inn & Suites Mount Pleasant

Quality Inn & Suites Mount Pleasant

Quality Inn & Suites Mount Pleasant
2.5 star property
Mount Pleasant
8.0 out of 10, Very Good, (116)
"The staff were absolutely great!!"
United States
Jacob
The price is ￥10,082
￥11,292 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Quality Inn & Suites Mount Pleasant
Free daily buffet breakfast
Holiday Inn Express Hotel & Suites Burlington by IHG

Holiday Inn Express Hotel & Suites Burlington by IHG

Holiday Inn Express Hotel & Suites Burlington by IHG
2.5 star property
Burlington
8.6 out of 10, Excellent, (467)
"Friendly staff and very clean hotel"
United States
Julie
The price is ￥19,571
￥22,544 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express Hotel & Suites Burlington by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southeast Iowa Hotel Reviews

Best Western Mt. Pleasant Inn

Best Western Mt. Pleasant Inn

10/10 Excellent
"Good value "
Jack 1-night trip
Posted 9 days ago
Best Western Mt. Pleasant Inn

Frequently asked questions

How much do business-friendly hotels in Southeast Iowa cost?
Expect to pay between ￥11,292 and ￥24,326 per night for business-friendly hotels in Southeast Iowa. Awesome deals on stays that are suitable for corporate travelers are a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business-friendly hotels are there in Southeast Iowa?
Southeast Iowa has 17 business-friendly hotels to choose from. Whether you're attending a conference or working remotely, these properties are equipped with everything you need to be productive.
Why book your business-friendly hotel in Southeast Iowa with Expedia?
Expedia will help you find a fabulous business-friendly hotel when work takes you on the road. From free WiFi and parking to gyms and spas, our stays come with all you'll need to settle that big contract.
How can I find cheap business-friendly hotels in Southeast Iowa?
Expedia can help you easily find cheap business-friendly hotels in Southeast Iowa. Simply head to the "traveler experience" filter and click on "business friendly." This will show you properties with amenities designed to help you work comfortably and efficiently, like included breakfast and free WiFi. You can also choose your hotel star rating and budget to keep costs down.
What is there to do in Southeast Iowa near my business-friendly hotel?
You'll find tons of attractions to see during your time in Southeast Iowa. If you've planned a couple of nights in Nauvoo, Rheinberger House Museum is a must-see.