Santa Cruz Vacations & Trips

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ￥45,448 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Santa Cruz Hotel Deals

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is ￥6,727 per night from Jan 10 to Jan 11
￥6,727
￥6,727 total
Jan 10 - Jan 11
9.4/10 Exceptional! (80 reviews)
Amazing breakfast

Reviewed on Jan 7, 2026

Ibis Santa Cruz DE LA Sierra
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
The price is ￥17,425 per night from Jan 16 to Jan 17
￥17,425
￥17,425 total
Jan 16 - Jan 17
9/10 Wonderful! (211 reviews)
Muy bien exelente

Reviewed on Dec 9, 2025

Marriott Santa Cruz de la Sierra Hotel
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
The price is ￥14,047 per night from Jan 9 to Jan 10
￥14,047
￥14,047 total
Jan 9 - Jan 10
8.2/10 Very Good! (332 reviews)
spotless

Reviewed on Dec 9, 2025

Sun Hotel
See all 312 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz vacation package cost?
We make it simple to travel the world, with Santa Cruz vacation packages starting from as little as . You'll have the flexibility to combine your favorite airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Santa Cruz?
One of the easiest ways to save money (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all covered. Pick a combination that best fits you and watch your savings pile up. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties across the world, which lets you customize your Santa Cruz adventure.
What are the top hotels in Santa Cruz?
For properties in Samaipata with cozy beds and friendly service, look up Sun Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel. If you're swinging by San Jose de Chiquitos as well, you'll get a great night's sleep at Camino Real Hotel or Marriott Santa Cruz de la Sierra Hotel.
How far in advance should I book my Santa Cruz vacation?
It's hard to pick the best time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to 12 months in advance. If you're booking late, don't stress. Discounted prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your favorite combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to create an exciting Santa Cruz escape.
What should I know before booking a Santa Cruz travel package?
Bundling your bookings into a Santa Cruz vacation package is the most convenient way to organize your trip. Not only that, you'll save just for combining your hotels, flights and car rentals. Once you've booked, why not add on a day tour or an activity?
Can I choose my airline with a Santa Cruz Expedia vacation package?
Yes — that's one of the best things about an Expedia package. You're in control. We have more than 550 airline partners throughout the world, so you have loads of choice when organizing your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz vacation package?
Yes you can, and we'll help you every step of the way. You may be able to change or cancel your Santa Cruz vacation package at no cost within 24 hours of booking. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, browse our Customer Service Portal for more information.

Discover the most popular places to visit in Santa Cruz

Plaza 24 de Septiembre which includes heritage architecture and heritage elements as well as a large group of people

Plaza 24 de Septiembre

The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.

Plaza 24 de Septiembre

Santa Cruz Zoo

Why not visit the native and exotic animals who call Santa Cruz Zoo home during your vacation in Santa Cruz? While in the area, you can find time to visit its shops.

Santa Cruz Zoo

What to do in Santa Cruz

Vallegrande City

Vallegrande City Tour

￥4,541
per adult
Vallegrande City Tour
Tickets Admission Ernesto Che Guevara Historical Museum in Vallegrande

Guided visit to the Che Guevara Memorial in Vallegrande

￥2,975
per adult
Guided visit to the Che Guevara Memorial in Vallegrande
Common grave, where the body of Che Guevara was found in 1997.

Guided tour of the Che Guevara Museum in Vallegrande

￥2,975
per adult
Guided tour of the Che Guevara Museum in Vallegrande
See all activities in Santa Cruz
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.