Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for Santa Cruz vacation rentals

A kitchen with a marble island, wooden stools, a white door, and a window with curtains.

1. la casa de Matias

la casa de Matias
2.0 star property
Volcán
8.0 out of 10, Very good, (1 review)
"The location on Google maps was very poor, we had to contact the owner because we couldn't find the house. In the house it would have been nice to have a closet to hang clothes, and some out door seating with a small table would be nice."
United States
Steven
The price is ￥6,825
￥7,609 total
includes taxes & fees
Nov 14 - Nov 15
la casa de Matias
A swing hanging from a tree in a grassy area with a view of a mountain and clouds in the background.

2. Linda Vista Cabins

Linda Vista Cabins
3.0 star property
Alto Boquete
9.2 out of 10, Wonderful, (18 reviews)
"Property was the best local accommodation I have had in Panama. The host was outstanding. "
United States
Don
The price is ￥8,708
￥9,580 total
includes taxes & fees
Nov 10 - Nov 11
Linda Vista Cabins
A covered seating area with two white plastic chairs and a small table, surrounded by neatly trimmed hedges and a palm tree.

3. Casa Little Italy

Casa Little Italy
3.0 star property
Tijeras
6.0 out of 10, (1 review)
"Didn't accept credit card payment "
Mexico
ANGELO
The price is ￥11,569
￥12,726 total
includes taxes & fees
Nov 10 - Nov 11
Casa Little Italy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Find vacation rentals that suit your style

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Top Santa Cruz Hotel Reviews

A room with two beds, wooden beams on the ceiling, a stone wall, a window with curtains, and a bedside table with a lamp.
Los Brezos Boutique Hotel

Los Brezos Boutique Hotel

Los Brezos Boutique Hotel
Volcan

10/10 Excellent

Good food, great staff and location is ideal for downtown area
United States
christine
Reviewed September 10, 2026
Los Brezos Boutique Hotel

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently Asked Questions

Can I find a vacation rental in Santa Cruz?

Yes, we give you a choice of vacation rentals near top local attractions in Santa Cruz, or you can select a secluded option if you're looking for relaxation.

What's the top vacation rental that Santa Cruz has to offer?

La casa de Matias: This vacation home rental outside of Santa Cruz offers a garden and free WiFi to help you feel comfortable in your new surroundings.

What’s there to see and do in Santa Cruz?

While you're exploring the area, Área Silvestre Protegida Lagunas de Volcán and Cerro Catalina are a couple of picturesque spots to get outside and enjoy nature. Paradise Tropical Garden and Barriles are a couple of places you'll find in the larger area.

What’s a vacation rental in Santa Cruz like?

A vacation rental is a private property you can book for a couple of days or more in Santa Cruz. Vacation rentals provide amenities like kitchens and laundry facilities so you'll have everything you want. If you're concerned about a clean environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you to travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for a family trip.