Santa Cruz Vacation Rentals

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Check prices for these dates

In two weeks
Jan 2 - Jan 4
In two months
Feb 13 - Feb 15
In three months
Mar 13 - Mar 15
In four months
Apr 10 - Apr 12

Our top choices for Santa Cruz vacation rentals

Grand Loft | Living area | Flat-screen TV
Lofts by Verticca

Apartment in Ojo de Agua

Lofts by Verticca
3.5 star property
8.2 out of 10, Very Good, (13)
"This was absolutely wonderful they were kind and friendly the loft was very clean and spacious only thing I didn’t like was the tv’s weren’t smart tv’s they only had local cable channels "
United States
Berline
The price is ￥11,000
￥13,200 total
includes taxes & fees
Dec 20 - Dec 21
Lofts by Verticca
Premium Studio | Premium bedding, in-room safe, iron/ironing board, free WiFi
UTOPIC Polanco by ULIV

Aparthotel in Miguel Hidalgo

UTOPIC Polanco by ULIV
4.5 star property
9.0 out of 10, Wonderful, (740)
"We had a great stay. Area was safe to walk around, and hotel was near tourist attractions. "
United States
Guadalupe
UTOPIC Polanco by ULIV
43-inch Smart TV with cable channels
Casa Chopo

Apartment in Downtown Mexico City

Casa Chopo
3.5 star property
9.4 out of 10, Exceptional, (103)
"Gorgeous property. "
United States
Jeff
The price is ￥6,742
￥8,158 total
includes taxes & fees
Dec 21 - Dec 22
Casa Chopo
Terrace/patio
A08 SUPER CITY SUITES AT PLAZA ACEQUIA

Apartment in Cuautitlan Izcalli

A08 SUPER CITY SUITES AT PLAZA ACEQUIA
3.5 star property
10.0 out of 10, Exceptional, (3)
"Limpio y cómodo "
Mexico
Caleb
A08 SUPER CITY SUITES AT PLAZA ACEQUIA
Lobby
Moderna, Cómoda Suite Nube en Tepotzotlán centro

Apartment in Tepotzotlán

Moderna, Cómoda Suite Nube en Tepotzotlán centro
4.0 star property
9.8 out of 10, Exceptional, (6)
"El lugar es maravilloso"
Mexico
Karen Lizeth
The price is ￥8,417
￥10,100 total
includes taxes & fees
Dec 21 - Dec 22
Moderna, Cómoda Suite Nube en Tepotzotlán centro
Reception
A05 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

Apartment in Cuautitlan Izcalli

A05 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
3.5 star property
10.0 out of 10, Exceptional, (2)
"Lo único que me disgusta es que no hay agua caliente )): Pero sin duda iré todos los 12 de cada mes "
Mexico
Jeik
The price is ￥7,614
￥12,245 total
includes taxes & fees
Dec 20 - Dec 21
A05 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
Exterior
A04 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

Apartment in Cuautitlan Izcalli

A04 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
3.5 star property
9.4 out of 10, Exceptional, (3)
"Buenas instalaciones y ubicación para mis desplazamientos"
Mexico
ANGEL
The price is ￥7,614
￥12,245 total
includes taxes & fees
Jan 5 - Jan 6, 2026
A04 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
Interior
Moderna, Comoda Suite Palma en Tepotzotlán centro

Apartment in Tepotzotlán

Moderna, Comoda Suite Palma en Tepotzotlán centro
3.0 star property
10.0 out of 10, Exceptional, (2)
"Excelente lugar "
Mexico
Teodoro
The price is ￥10,100
￥12,120 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Moderna, Comoda Suite Palma en Tepotzotlán centro
Family Studio Suite, 1 Bedroom, Balcony, City View | Balcony
S09 PREMIUM SUITE Full Service WiFi

Apartment in Ciudad López Mateos

S09 PREMIUM SUITE Full Service WiFi
4.0 star property
9.6 out of 10, Exceptional, (4)
"Excelente"
United States
Yulissa Rubi
The price is ￥6,175
￥10,518 total
includes taxes & fees
Dec 23 - Dec 24
S09 PREMIUM SUITE Full Service WiFi
Junior Apartment | Living area | Flat-screen TV
Bright & sweet unit in middle Polanco

Apartment in Polanco

Bright & sweet unit in middle Polanco
3.0 star property
9.8 out of 10, Exceptional, (44)
"Very cozy and clean. Good walking distance from all types of restaurants."
United States
Lissette
The price is ￥7,847
￥13,382 total
includes taxes & fees
Dec 23 - Dec 24
Bright & sweet unit in middle Polanco
Outdoor wedding area
The Wild Oscar

Aparthotel in Polanco

The Wild Oscar
4.0 star property
9.6 out of 10, Exceptional, (487)
"Don't delay - book the Wild Óscar "
United States
Kasha
The Wild Oscar
Terrace/patio
Las Suites Campos Eliseos

Aparthotel in Polanco

Las Suites Campos Eliseos
4.0 star property
9.2 out of 10, Wonderful, (1350)
"The staff was top notch"
United States
Alan
The price is ￥23,537
￥28,127 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Las Suites Campos Eliseos
Terrace/patio
A10 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

Apartment in Cuautitlan Izcalli

A10 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
3.5 star property
9.2 out of 10, Wonderful, (5)
"Muy buena experiencia, todo muy claro y es diferente a lo convencional, tal vez digan que por el precio serán instalaciones no muy agradables, pero en verdad hay sorpresas recomendado ampliamente, la persona encargada de cuidar es muy amable y atento!!! "
Mexico
Jorge
The price is ￥7,614
￥12,245 total
includes taxes & fees
Dec 20 - Dec 21
A10 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
Rooftop terrace
A07 SUPER CITY SUITES AT PLAZA ACEQUIA

Apartment in Cuautitlan Izcalli

A07 SUPER CITY SUITES AT PLAZA ACEQUIA
3.5 star property
10.0 out of 10, Exceptional, (2)
"Buen lugar tranquilo "
Mexico
Valeria
The price is ￥7,769
￥9,323 total
includes taxes & fees
Jan 1 - Jan 2, 2026
A07 SUPER CITY SUITES AT PLAZA ACEQUIA
Exterior
A13 SUPER CITY SUITE PLAZA ACEQUIA

Apartment in Cuautitlan Izcalli

A13 SUPER CITY SUITE PLAZA ACEQUIA
3.5 star property
10.0 out of 10, Exceptional, (1)
"Buen servicio "
Mexico
Ruben
The price is ￥7,614
￥12,158 total
includes taxes & fees
Jan 17 - Jan 18, 2026
A13 SUPER CITY SUITE PLAZA ACEQUIA
Sundeck
A14 SUPER PREMIUM SUITE AT PLAZA ACEQUIA

Apartment in Cuautitlan Izcalli

A14 SUPER PREMIUM SUITE AT PLAZA ACEQUIA
3.5 star property
9.4 out of 10, Exceptional, (6)
"Buena la estancia "
Mexico
Héctor
The price is ￥7,614
￥12,245 total
includes taxes & fees
Dec 20 - Dec 21
A14 SUPER PREMIUM SUITE AT PLAZA ACEQUIA
Premium Apartment, Terrace | Living area | 40-inch flat-screen TV with digital channels
Capitalia Nuevo Polanco

Apartment in Miguel Hidalgo

Capitalia Nuevo Polanco
4.0 star property
9.2 out of 10, Wonderful, (35)
"Location and the apartment were wonderful. "
United States
David
The price is ￥11,974
￥16,044 total
includes taxes & fees
Dec 22 - Dec 23
Capitalia Nuevo Polanco
Aerial view
ULIV Apartments Polanco

Aparthotel in Miguel Hidalgo

ULIV Apartments Polanco
4.0 star property
8.8 out of 10, Excellent, (301)
"Easy check in and out and a great apartment "
Canada
Jose
ULIV Apartments Polanco
Deluxe Apartment, Balcony, City View | Hypo-allergenic bedding, in-room safe, individually decorated
Kukun Homero Polanco

Apartment in Polanco

Kukun Homero Polanco
4.0 star property
9.4 out of 10, Exceptional, (215)
"Loved the view from the balcony and very friendly staff. "
United States
Claudia
The price is ￥17,913
￥21,713 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Kukun Homero Polanco
Front of property
Park Life Lamartine

Apartment in Polanco

Park Life Lamartine
3.0 star property
9.0 out of 10, Wonderful, (9)
"Everything was perfect! I highly recommend this place if you’re traveling to Polanco."
United States
Abraham
The price is ￥15,863
￥19,194 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Park Life Lamartine
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

UTOPIC Polanco by ULIV

UTOPIC Polanco by ULIV

10/10 Excellent
"Everything was as described, clean and pleasant. The only issue was when I repeatedly asked for water, and they informed me that they hadn’t received any, so they couldn’t provide it."
Anakaren 3-night trip
Posted 3 days ago
UTOPIC Polanco by ULIV

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
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Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Are there vacation rentals in Santa Cruz?

Yes, you can find vacation rentals near popular points of interest in Santa Cruz, or you can go with a secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

Polanco Stay: Outdoor Space & Explore Nearby: This vacation home rental near Santa Cruz offers a garden, a selection of games, and laundry facilities to help you feel perfectly comfortable in your new surroundings. It has 7 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family.

What’s there to see and do in Santa Cruz?

Explore the area and family-friendly sights such as Planetario Luis Enrique Erro, or get out into nature at a spot like Hacienda La Concepcion. Temple of San Francisco Javier and National Museum of the Viceroyalty are a couple of places you'll find in the larger area.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties you can book for a long or short time in Santa Cruz. Vacation rentals feature extras such as patios, hot tubs, and fire pits so you'll feel just like you're at home. If you're concerned about a clean environment, vacation rentals can provide a sense of seclusion away from public hotel elevators and busy front desks while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for family trips.