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Go beyond your typical stay in Santa Cruz Tlaxcala

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Check prices for these dates

Tonight
Nov 14 - Nov 15
Tomorrow
Nov 15 - Nov 16
Next weekend
Nov 20 - Nov 22
In two weeks
Nov 27 - Nov 29

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Our top choices for Santa Cruz Tlaxcala hotels

A corridor with stone walls, wooden beams, and potted plants.

1. Centro Vacacional La Trinidad

Centro Vacacional La Trinidad
2.5 star property
Santa Cruz Tlaxcala
6.4 out of 10, (12 reviews)
"Overall, the property is old, the room was little bit dirty, front desk very rude, the rest were very kind."
United States
marelis
The price is ￥8,113
￥9,852 total
includes taxes & fees
Nov 22 - Nov 23
Centro Vacacional La Trinidad
A spacious restaurant with high wooden ceilings, blue walls, and a central bar area.

2. Hotel San Francisco Tlaxcala

Hotel San Francisco Tlaxcala
3.5 star property
Tlaxcala
9.0 out of 10, Wonderful, (560 reviews)
"What Diamond! Great place to stay."
United States
Luis Daniel
The price is ￥11,761
￥13,878 total
includes taxes & fees
Nov 29 - Nov 30
Hotel San Francisco Tlaxcala
A modern hotel with a glass facade, multiple floors, and a prominent signage for 'Encore'.

3. Ramada Encore by Wyndham Puebla

Ramada Encore by Wyndham Puebla
4.0 star property
Coronango
9.2 out of 10, Wonderful, (1,002 reviews)
"Excelente hotel"
Mexico
Marisol
The price is ￥9,805
￥11,668 total
includes taxes & fees
Nov 24 - Nov 25
Ramada Encore by Wyndham Puebla
A stone building with a large wooden door and a covered entrance.

4. Holiday Inn Tlaxcala by IHG

Holiday Inn Tlaxcala by IHG
3.5 star property
Yauhquemehcan
9.6 out of 10, Exceptional, (323 reviews)
"Beautiful and historic hotel. A gem in Tlaxcala."
United States
Ian
The price is ￥16,189
￥19,103 total
includes taxes & fees
Dec 14 - Dec 15
Holiday Inn Tlaxcala by IHG
A hotel room with a bed, desk, chair, and a window with a view.

5. City Express by Marriott Apizaco

City Express by Marriott Apizaco
3.0 star property
Apizaco
9.2 out of 10, Wonderful, (484 reviews)
"Nice hotel, excellent location."
United States
Adelfo
The price is ￥8,859
￥10,454 total
includes taxes & fees
Dec 9 - Dec 10
City Express by Marriott Apizaco
A restaurant with outdoor seating, wooden tables, and chairs, a large TV screen, and a banner with text.

6. Hotel Senorial Tlaxcala

Hotel Senorial Tlaxcala
3.5 star property
Tlaxcala
8.8 out of 10, Excellent, (176 reviews)
"Great option"
United States
Maria
The price is ￥10,840
￥12,791 total
includes taxes & fees
Nov 16 - Nov 17
Hotel Senorial Tlaxcala
A modern hotel lobby with a seating area, a kitchenette, and a view of the city.

7. City Express Junior by Marriott Puebla Finsa

City Express Junior by Marriott Puebla Finsa
3.0 star property
Cuautlancingo
8.8 out of 10, Excellent, (559 reviews)
"Todo excelente"
Mexico
Emmanuel
The price is ￥5,953
￥7,085 total
includes taxes & fees
Dec 7 - Dec 8
City Express Junior by Marriott Puebla Finsa
A hotel room with a bed, a chair, a nightstand, and a view of a cityscape.

8. Hotel Mirante Tlaxcala

Hotel Mirante Tlaxcala
4.0 star property
Tlaxcala
9.6 out of 10, Exceptional, (153 reviews)
"Clean room, amazing staff, Greta location and love that parking is included"
United States
María José
The price is ￥8,570
￥10,112 total
includes taxes & fees
Nov 24 - Nov 25
Hotel Mirante Tlaxcala
A courtyard with a fountain, well-kept hedges, and a building with multiple balconies and arched windows.

9. Hotel del Angel, Apizaco

Hotel del Angel, Apizaco
3.5 star property
San Martin de Porres
8.8 out of 10, Excellent, (312 reviews)
"Bonito Hotel"
Mexico
jc
The price is ￥12,794
￥15,097 total
includes taxes & fees
Dec 6 - Dec 7
Hotel del Angel, Apizaco
A courtyard with a fountain, neatly trimmed hedges, and a building with multiple balconies.

10. Hotel GS Jerocs

Hotel GS Jerocs
3.0 star property
Tlaxcala
8.2 out of 10, Very good, (355 reviews)
"Hotel is very nice and clean. The staff is very nice and accommodating."
Canada
Marisu
The price is ￥17,509
￥20,898 total
includes taxes & fees
Nov 17 - Nov 18
Hotel GS Jerocs
A hotel room with a bed, a bathroom with a sink, a mirror, a television, and a window.

11. Hotel Tlaxcala

Hotel Tlaxcala
3.5 star property
Tlaxcala
8.2 out of 10, Very good, (115 reviews)
"The Hotel is nice and clean just a suggestion ... have an extra blanket because in this time of the year is cold and the hotel doesn't have a heater, also just check your towels some of them are really old. Other than that is close to everything, the food is good the staff are all nice."
United States
Angelica
The price is ￥7,153
￥8,441 total
includes taxes & fees
Nov 15 - Nov 16
Hotel Tlaxcala
A building with a covered outdoor seating area, a metal railing, and planters with grass.

12. Hotel La Posada

Hotel La Posada
3.0 star property
Apizaco
8.0 out of 10, Very good, (76 reviews)
"Buen trato"
Mexico
Eduardo
The price is ￥8,745
￥10,319 total
includes taxes & fees
Nov 16 - Nov 17
Hotel La Posada
A cozy seating area with a wicker basket of pastries and coffee cups on a wooden table.

13. Hacienda Soltepec Suites Campo de Golf

Hacienda Soltepec Suites Campo de Golf
3.0 star property
Huamantla
9.0 out of 10, Wonderful, (282 reviews)
"I really liked the property it is very quiet and safe. loved it! Definitely will stay here again!"
United States
Luz
The price is ￥15,891
￥18,752 total
includes taxes & fees
Nov 17 - Nov 18
Hacienda Soltepec Suites Campo de Golf
A stone building entrance with a sign reading "POSADA ACASONA DE CORTES".

14. Hotel Posada La Casona de Cortes

Hotel Posada La Casona de Cortes
3.0 star property
Tlaxcala
8.4 out of 10, Very good, (218 reviews)
"Beautiful hotel"
United States
Atilio
The price is ￥6,092
￥7,189 total
includes taxes & fees
Nov 20 - Nov 21
Hotel Posada La Casona de Cortes
A covered outdoor seating area with a tiled floor, metal railing, and hanging plants.

15. HOTEL XIADANI temazcal y SPA

HOTEL XIADANI temazcal y SPA
3.0 star property
Tlaxcala
9.0 out of 10, Wonderful, (75 reviews)
"excelente"
Mexico
Danae
The price is ￥5,575
￥6,579 total
includes taxes & fees
Nov 20 - Nov 21
HOTEL XIADANI temazcal y SPA
A restaurant with outdoor seating, a view of the city, and a mural on the wall.

16. Hotel de La Loma

Hotel de La Loma
3.0 star property
Tlaxcala
8.8 out of 10, Excellent, (254 reviews)
"The view and walking distance to centro."
Canada
Mario
The price is ￥5,341
￥6,302 total
includes taxes & fees
Dec 6 - Dec 7
Hotel de La Loma
A restaurant interior with multiple wooden tables and chairs, a bar area, and a television screen on the wall.

17. Hotel 1904

Hotel 1904
3.0 star property
Apizaco
8.0 out of 10, Very good, (118 reviews)
"Clean room, street parking"
United States
Eduardo
The price is ￥9,287
￥10,959 total
includes taxes & fees
Nov 17 - Nov 18
Hotel 1904
A building with a balcony, brick walls, and windows with lights.

18. Hotel de la Capilla

Hotel de la Capilla
2.0 star property
Tlaxcala
8.8 out of 10, Excellent, (66 reviews)
"Quaint and super clean place, near everything, right in the middle of historic places, the market, cafés, museums. Lovely place to stay."
Canada
Diana
The price is ￥7,739
￥9,132 total
includes taxes & fees
Nov 15 - Nov 16
Hotel de la Capilla
A hotel with a blue facade, named HOTEL BOUTIQUE LAS TORRES.

19. Capital O Hotel Boutique Las Torres

Capital O Hotel Boutique Las Torres
3.0 star property
Tlaxcala
9.2 out of 10, Wonderful, (99 reviews)
"Excelente"
Mexico
Claudia Ivón López
The price is ￥7,420
￥9,497 total
includes taxes & fees
Nov 29 - Nov 30
Capital O Hotel Boutique Las Torres
A modern bedroom with a large bed, two bedside tables, and a patterned rug.

20. Mesón Santa Rosa

Mesón Santa Rosa
3.0 star property
Tlaxcala
9.6 out of 10, Exceptional, (67 reviews)
"Excellent location, quiet, wonderful service and great price. Would definitely stay there again. "
United States
Mario
The price is ￥9,055
￥10,685 total
includes taxes & fees
Nov 16 - Nov 17
Mesón Santa Rosa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Tlaxcala Hotel Reviews

A hotel room with a bed, desk, chair, and a window with a view.
City Express by Marriott Apizaco

City Express by Marriott Apizaco

City Express by Marriott Apizaco
Apizaco

10/10 Excellent

Me gustó atención, la limpieza y el desayunó rico a parte tiene un despachador de agua caliente y café y en las tardes tomar un te o un café antes de dormir, lo que no me gustó que la coladera de la regadera se estancaba el agua y se tardaba en irse tal vez se necesita limpiar la coladera de la regadera.
United States
Emma
Reviewed May 25, 2026
City Express by Marriott Apizaco

Frequently Asked Questions

What are some of the best vacation home rentals that Santa Cruz Tlaxcala has to offer?

Luxurious Casa Residencial Privada: This highly rated vacation home rental in Santa Cruz Tlaxcala offers a balcony and laundry facilities to help you feel comfortable in your new surroundings. Kitchen amenities like a microwave and kitchenware can make your vacation run smoothly. See all vacation rentals in Santa Cruz Tlaxcala.

If I need to cancel my hotel reservation in Santa Cruz Tlaxcala, will I receive a refund?

Yes, you'll find most hotel reservations are refundable if you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of check in. If your reservation is non-refundable, it might still be possible to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz Tlaxcala.

Where can I learn more about changing or cancelling my trip to Santa Cruz Tlaxcala?

To access more information about rescheduling or cancelling your trip to Santa Cruz Tlaxcala, head over to our customer service page.