A vineyard with rows of grapevines.

Find hotels in Santa Cruz from ¥6,149

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Aug 7 - Aug 8
Tomorrow
Aug 8 - Aug 9
This weekend
Aug 7 - Aug 9
Next weekend
Aug 14 - Aug 16

Filter by

Property class

Guest rating

Our top choices for Santa Cruz hotels

Breakfast included
Hotel
Wifi Included
Reserve now, pay later
Pool

1. Hotel Boutique Vendimia Premium

Hotel Boutique Vendimia Premium
Santa Cruz
United States
Jose
¥13,623
¥13,623 total
Aug 8 - Aug 9
Hotel Boutique Vendimia Premium

2. Hotel Vendimia Parador

Hotel Vendimia Parador
Santa Cruz
United States
Pawel
¥13,134
¥13,134 total
Aug 31 - Sep 1
Hotel Vendimia Parador

3. Santa Cruz Plaza

Santa Cruz Plaza
Santa Cruz
Canada
William
¥16,682
¥16,682 total
Aug 12 - Aug 13
Santa Cruz Plaza

4. Hotel Cava Colchagua

Hotel Cava Colchagua
Santa Cruz
Canada
Anonymous traveler
¥20,819
¥20,819 total
Aug 19 - Aug 20
Hotel Cava Colchagua

5. Casa Calfu

Casa Calfu
Santa Cruz
Australia
Mary
¥12,116
¥12,116 total
Aug 9 - Aug 10
Casa Calfu

6. TerraViña

TerraViña
Santa Cruz
United Kingdom
DARREN
¥19,967
¥19,967 total
Aug 9 - Aug 10
TerraViña

7. Hotel Boutique Grand Cru

Hotel Boutique Grand Cru
Santa Cruz
United States
Jonathan
¥15,527
¥15,527 total
Aug 15 - Aug 16
Hotel Boutique Grand Cru

8. La Perla Hotel

La Perla Hotel
Santa Cruz
Canada
Nancy
¥13,078
¥13,078 total
Sep 1 - Sep 2
La Perla Hotel

9. Hostal Vida 2000

Hostal Vida 2000
Santa Cruz
United States
Kati
¥6,149
¥6,149 total
Aug 9 - Aug 10
Hostal Vida 2000

10. Colchagua Tiny Lodge

Colchagua Tiny Lodge
Santa Cruz
United States
Jonathan
¥24,892
¥24,892 total
Aug 19 - Aug 20
Colchagua Tiny Lodge

11. Noi Blend Colchagua

Noi Blend Colchagua
Palmilla
United States
Barbara
¥25,102
¥25,102 total
Aug 8 - Aug 9
Noi Blend Colchagua

12. Hotel Ontiveros

Hotel Ontiveros
San Fernando
Canada
Gordon
¥11,492
¥11,492 total
Aug 8 - Aug 9
Hotel Ontiveros

13. Hotel Central

Hotel Central
San Fernando
¥9,610
¥9,610 total
Aug 15 - Aug 16
Hotel Central

14. Vik Chile

Vik Chile
San Vicente
Brazil
Rafael
¥99,725
¥99,725 total
Sep 2 - Sep 3
Vik Chile

15. Hotel Viña La Playa

Hotel Viña La Playa
Peralillo
Mexico
Manuel
¥40,017
¥40,017 total
Aug 12 - Aug 13
Hotel Viña La Playa

16. Hacienda Histórica Marchigüe

Hacienda Histórica Marchigüe
Marchihue
United States
Anonymous traveler
¥31,219
¥31,219 total
Aug 14 - Aug 15
Hacienda Histórica Marchigüe
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Santa Cruz attractions

Lapostolle Clos Apalta Winery

9.4/10 (21 reviews)
Carved into the hillside, Clos Apalta Winery produces award-winning Bordeaux-style wines using a gravitational system. Reserve a private tour to taste premium vintages overlooking the stunning Colchagua Valley.
See properties

Casino Colchagua

8.0/10 (6 reviews)
Chile's first thematic casino blends gaming with colonial-inspired decor that celebrates local heritage. Enjoy slot machines and table games while savoring Chilean cuisine from the adjacent Hotel Santa Cruz Plaza.
See properties

Colchagua Campo y Vino

9.4/10 (3 reviews)
Immerse yourself in Chile's wine country at this boutique hotel surrounded by Colchagua Valley vineyards. Enjoy personalized service while exploring nearby wineries during harvest festivals or spring blooms.
See properties

Museo de Colchagua

9.6/10 (24 reviews)
This renowned private museum houses one of Latin America's most extensive historical collections from prehistoric to modern Chile. Explore pavilions featuring indigenous artifacts and colonial treasures.
See properties

Bodega Viña Viu Manent

10.0/10 (1 review)
This historic Chilean winery stands out for its exceptional Malbec wines, a rarity in the region. Take a horse-drawn carriage through sun-dappled vineyards before sampling their acclaimed vintages.
See properties

Laura Hartwig Winery

9.0/10 (17 reviews)
This family-run winery in Chile's Colchagua Valley specializes in premium Bordeaux-style wines. Stroll through picturesque vineyards before enjoying intimate tastings paired with local cheeses in their barrel room.
See properties

Plaza de Armas

8.2/10 (34 reviews)
This elegant city square features symmetrical walkways and lush gardens at the heart of Santa Cruz. Relax beneath towering trees or catch local cultural events that showcase the region's vibrant community life.
See properties

Learn more about Santa Cruz

Nestled in the heart of wine country, Santa Cruz invites visitors to taste world-class Colchagua Valley wines at family-owned vineyards. Museum of Colchagua showcases impressive pre-Columbian artifacts while the Plaza de Armas offers local crafts and regional foods on weekends.

See all hotels in Santa Cruz
A vineyard with rows of grapevines.

Top Santa Cruz Hotel Reviews

TerraViña

TerraViña

10/10 Excellent
"세번째 방문이지만 여전히 좋은 호텔입니다. 주변의 콜차구아 박물관은 깜짝 놀랄 미이라 머리가 있습니다."
MinSeok James 1-night trip
Posted 2 months ago
TerraViña
Hotel Vendimia Parador

Hotel Vendimia Parador

10/10 Excellent
" "I had a wonderful experience at this hotel. The location is fantastic—central and convenient to everything I wanted to see. The room was spotless and well-maintained, which I really appreciated. But what truly sets this place apart is the staff. From the front desk to the housekeeping team, everyone was genuinely warm, helpful, and went out of their way to be friendly. It made all the difference. I would absolutely stay here again." "
Yorba 1-night trip
Posted 5 months ago
Hotel Vendimia Parador
Hotel Boutique Grand Cru

Hotel Boutique Grand Cru

10/10 Excellent
"Great breakfast. Super host Juan Luis. Great location. Comfy bed. Spacious loft style rooms "
Martin 1-night trip
Posted 5 months ago
Hotel Boutique Grand Cru
Casa Calfu

Casa Calfu

10/10 Excellent
"Excellent "
Agnes 2-night trip
Posted 5 months ago
Casa Calfu

More cheap stays in Santa Cruz

Hostal Vida 2000

Hostal Vida 2000

Ismael Valdes 245 Santa Cruz
¥6,149
¥6,149 total
Aug 9 - Aug 10
5.4/10 (3 reviews)
Hostal Vida 2000
Intown Apart Santa Cruz

Intown Apart Santa Cruz

Claudio Cancino 92 Santa Cruz O'Higgins
Get rates
10/10 Exceptional! (1 review)
Intown Apart Santa Cruz
La Ruta del Jazz

La Ruta del Jazz

Villa Yucatan Santa Cruz
Get ratesLa Ruta del Jazz
Weekend & Wine B&B

Weekend & Wine B&B

Av. 21 de mayo 0317, con Av Las Toscas, Santa cruz Libertador General Bernardo O'Higgins
Get ratesWeekend & Wine B&B
Hosteria No me Olvides

Hosteria No me Olvides

Agustin besoain 320 Curicó Maule (region)
Get ratesHosteria No me Olvides
Casa Suiza - Hostel

Casa Suiza - Hostel

Los Libertadores 199, Santa Cruz, Chile Santa Cruz Santa Cruz
Get ratesCasa Suiza - Hostel

Find out more about Santa Cruz

Top reasons to visit Santa Cruz

  • Scenic Outdoor Adventures: Santa Cruz boasts stunning hiking trails and coastal walks, perfect for outdoor enthusiasts seeking adventure.
  • Rich Cultural Experiences: Discover local culture through food tours, historic buildings, and museums showcasing the region's history.
  • Charming Santa Cruz Wharf: Enjoy scenic views at the Santa Cruz Wharf, a must-visit spot for picturesque photo opportunities.
  • Winery Excursions: Indulge in luxurious wines at nearby vineyards, enhancing your culinary experience in this wine-rich region.
  • Vibrant Nightlife: Experience the lively nightlife that blends entertainment and cultural immersion, making your trip unforgettable.

Find great hotels in and around Santa Cruz

Explore a variety of hotel accommodations in Santa Cruz, O'Higgins Region, Chile, tailored for every traveler. From charming bed & breakfasts to comfortable hotels, you’ll find options perfect for winery enthusiasts, spa seekers, and adventure lovers. Discover the best Santa Cruz hotels, complete with reviews and amenities to enhance your stay in this beautiful destination.

  • Santa Cruz Plaza: Situated in the heart of Santa Cruz, the 4-star Santa Cruz Plaza offers a welcoming atmosphere ideal for families and adventure seekers alike. With a commendable guest rating of 8.8, this hotel features a variety of exciting activities such as hiking, rafting, and kayaking nearby, perfect for those looking to explore the stunning natural surroundings. Family-friendly amenities include babysitting services and a children's club, ensuring younger guests are well catered for. Experience the thrill of adventure sports while enjoying the comfort and convenience of a centrally located hotel.
  • Vik Chile: Located about 16km from Santa Cruz, Vik Chile is a luxurious 5-star property that combines adventure with a winery and spa experience, earning a remarkable guest rating of 9.2. Guests can indulge in onsite horse riding and mountain biking, or unwind in the full-service spa offering various body treatments and massages. The hotel's vineyard provides easy access to wine tasting and private vineyard tours, making it a unique getaway for wine enthusiasts and relaxation seekers. Enjoy breathtaking views and exceptional service in this serene setting.
  • TerraViña: Nestled in Santa Cruz, the 3-star TerraViña boasts a charming ambiance that appeals to couples and nature lovers, with a guest rating of 9.2. Adventure enthusiasts can explore onsite mountain biking and horseback riding, while romantic packages elevate the guest experience. Delight in winery tours and private tastings, complemented by spa and outdoor pool services for a refreshing retreat. The hotel's focus on wellness and nature is reflected in its beautifully designed outdoor spaces, including furnished balconies and picnic areas, providing a tranquil escape.

Where to stay near Santa Cruz

Santa Cruz, nestled in the O'Higgins Region of Chile, offers a delightful blend of romance and adventure. Explore its charming streets, indulge in luxurious wines, or relax in its picturesque landscapes. Nearby attractions provide thrilling excursions and vibrant atmospheres, making it an ideal destination for both relaxation and entertainment. Don't miss the lively resorts reminiscent of Santa Cruz, California, and the beautiful vibes of South Tenerife in the Canary Islands for a truly unforgettable experience.

  • Colchagua Valley Wine Route: Nestled just 10km from Santa Cruz, the Colchagua Valley Wine Route is a haven for wine enthusiasts and outdoor lovers alike. The region is known for its romantic atmosphere and entertainment options, making it a popular destination, especially from January to March. Visitors can indulge in scenic hiking trails or enjoy skiing in the nearby fields. With stunning beaches and event venues close by, this area offers a perfect blend of relaxation and adventure, making it an ideal stop for any traveler.
  • Cunaco: Located 6km from Santa Cruz, Cunaco is a charming village that attracts visitors seeking a mix of romance and outdoor experiences. The village sees peak tourist activity from January to March, with a quieter atmosphere from June to August. Cunaco is renowned for its ski fields, presenting thrilling opportunities for winter sports enthusiasts. Additionally, history buffs will appreciate the local history museum, which offers a glimpse into the region's past, making it a worthwhile stop for anyone looking to immerse themselves in the local culture.
  • Palmilla: Just 13km from Santa Cruz, Palmilla is a vibrant city that welcomes visitors year-round, with peak seasons in February to March and September. Known for its romantic settings and outdoor activities, Palmilla offers hiking trails and skiing options for adventure seekers. The city boasts beautiful beaches and event venues, alongside stunning coastal views at the cape. Whether you're looking to relax by the beach or explore the outdoors, Palmilla provides an ideal balance of leisure and excitement, ensuring a memorable vacation experience.

Things to do in Santa Cruz

Shopping

In Santa Cruz, visit the local artisan market for handmade crafts and unique souvenirs. If you're up for a drive, head to the Plaza de Armas for more shops and boutiques, offering a variety of gifts showcasing Chilean culture and craftsmanship.

Recreation

In Santa Cruz, explore the tranquil ambiance of Viña Santa Cruz's wellness center, where you can indulge in soothing massages and rejuvenating treatments surrounded by picturesque vineyards. For outdoor recreation, hike through the breathtaking landscapes of the Colchagua Valley, embracing nature and serenity amidst the stunning scenery.

Adventure

Explore the Colchagua Valley by embarking on a wine tour, where you can taste exquisite local wines and enjoy the beautiful vineyard landscapes. For an adrenaline rush, try horseback riding through the scenic hills, offering a unique perspective of the region's natural beauty.

Nightlife

In Santa Cruz, the lively bars and restaurants offer a vibrant atmosphere, perfect for mingling and enjoying local wines. Venues like Café del Vino present an inviting spot for wine tastings, while La Casona features live music, creating an engaging nightlife scene to explore.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Cruz

To save money during your visit to Santa Cruz, plan your trip for March, August, or December when accommodation prices are lower. Booking your hotel about a month in advance can secure better rates, especially if you opt for a Tuesday stay, the cheapest day. Consider using Expedia’s search tool to find budget-friendly options and package deals that combine flights and accommodations. Don't forget to look for last-minute deals and free cancellation policies to maximize savings while enjoying free activities like exploring local parks and vineyards.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Santa Cruz are March, August and December, where the prices are slightly lower. This is in comparison to April to May and October, where prices are slightly higher.
  • The best time to book a hotel: Book your hotel in Santa Cruz about 1 month out to secure some of the cheapest prices. If you're the spontaneous type, Expedia's last minute deals and discounts are indicated via the green label below the price.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Santa Cruz is Tuesday. The most expensive day to stay in Santa Cruz is Sunday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your options based on your budget, desired location, and preferred type of accommodation. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in Santa Cruz with your flights and activities through an Expedia package deal.

Find the best attractions in and around Santa Cruz

Santa Cruz, located in the O'Higgins Region of Chile, offers a delightful mix of romantic and outdoor experiences. Visitors can explore attractions like historic buildings and museums that showcase the local culture and history. Don't miss a visit to the Santa Cruz Wharf for scenic views, and if you're curious, Santa Cruz de Tenerife is another intriguing spot nearby. This charming destination is perfect for those seeking a blend of entertainment and cultural immersion.

  • Colchagua Campo y Vino: Immerse yourself in the serene ambiance of Colchagua Campo y Vino, where you can enjoy relaxing excursions amidst lush vineyards. This attraction offers a luxurious experience, allowing you to savor fine wines while soaking in the picturesque landscapes of the Colchagua Valley.
  • Hacienda El Huique: Located 13km from Santa Cruz, Hacienda El Huique is a historic building that showcases the rich cultural heritage of the region. Explore its beautifully preserved architecture and learn about the local history that shaped this charming estate.
  • Plaza de Armas: Situated in the heart of Santa Cruz, Plaza de Armas is a vibrant city square that exudes cultural charm. Take a leisurely stroll, enjoy local eateries, and experience the lively atmosphere that reflects the spirit of the community.

Best time to go to Santa Cruz

The best time to visit Santa Cruz is dependent on what kind of holiday you are seeking. January is its hottest month on average. At this time, visitor numbers are slightly high and weather is sunny with no rain. July is its coolest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January72.5°F (22.5°C)No RainSunnySlightly HighAverage
February71.6°F (22.0°C)No RainSunnySlightly HighAverage
March68.4°F (20.2°C)No RainSunnySlightly HighSlightly Low
April61.5°F (16.4°C)No RainSunnyAverageSlightly High
May55.2°F (12.9°C)Light RainMostly SunnySlightly LowSlightly High
June49.6°F (9.8°C)Light RainMostly SunnyAverageSlightly High
July47.5°F (8.6°C)Light RainMostly SunnyAverageAverage
August50.0°F (10.0°C)Light RainMostly SunnyAverageAverage
September53.2°F (11.8°C)Light RainMostly SunnyAverageAverage
October57.9°F (14.4°C)No RainSunnySlightly LowAverage
November64.6°F (18.1°C)No RainSunnySlightly LowSlightly Low
December69.3°F (20.7°C)No RainSunnyAverageSlightly Low

The nearest major airports for your trip to Santa Cruz

Traveling to Santa Cruz, O'Higgins Region, Chile, is convenient via Santiago's Arturo Merino Benitez Airport (SCL), situated 148km away. Top nearby hotels include The Singular Santiago, a luxurious 5-star option located 14km from the airport, offering 24-hour airport shuttle services. NH Ciudad de Santiago, a 4.5-star hotel about 16km from SCL, also provides airport shuttles upon request. Another great choice is Luciano K Hotel, also 16km away, featuring various transportation options including airport transfers. With these accommodations, accessing Santa Cruz from Santiago’s airport is seamless and comfortable.

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Based on our traveler data, Santa Cruz Plaza is one of the top choices for your stay. This hotel offers a full-service spa and a restaurant. Other good choices for your trip include Hotel Vendimia Parador and La Perla Hotel. See all available top hotels, or vacation rentals in Santa Cruz.
What are some of the best vacation home rentals that Santa Cruz has to offer?
Hostel Turismo San Vicente Tagua Tagua: This vacation home rental outside of Santa Cruz has laundry facilities and cable TV to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms and a kitchenette with kitchenware. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
To access more information about changing or cancelling your trip to Santa Cruz, head over to our customer service page.
What's the best budget-friendly hotel in Santa Cruz?
Based on our traveler reviews, Casa Suiza - Hostel is a top choice for a less expensive stay. Other choices to stay on the cheap include Hostal Gomero and Hostal Cepa Noble. View all budget hotels in Santa Cruz.
What's the best hotel for families in Santa Cruz?
Santa Cruz Plaza is a hotel with an outdoor pool and a free kids' club, and it's a top choice on Expedia for families. Kids of all ages will also enjoy a visit to Colchagua Campo y Vino. Find more child-friendly accommodations in Santa Cruz.
What's the best pet-friendly place to stay in Santa Cruz?
Hotel Vendimia Parador is a top hotel for people traveling with their pets, and offers an indoor pool and an outdoor pool for its human guests. Two other good options for you and your pet's trip include Parcela con tranque, sala de juegos, terraza, and Hotel Hoja de Parra. See more pet-friendly hotel accommodations in Santa Cruz.
Where is the best place to stay close to Plaza de Armas?
Adjacent to Plaza de Armas, Santa Cruz Plaza is one of the top choices for your stay based on our traveler data, and this 4-star hotel offers a full-service spa and a restaurant. Other good choices close by include Intown Apart Santa Cruz and Tierra y Vino.
What about the best place to stay close to Museo de Colchagua?
One of the top choices for your stay is Santa Cruz Plaza, located next to Museo de Colchagua, and this 4-star hotel offers a full-service spa and a restaurant. La Perla Hotel and Tierra y Vino are two other good choices in the immediate area.
What's the best luxury hotel in Santa Cruz?
Vibo Wine Lodge is a luxury lodge with a winery and private balconies, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Find more luxury hotels in Santa Cruz.
What are some accommodations with pools in Santa Cruz?
Hotel Vendimia Parador is a top hotel with an indoor pool, an outdoor pool, and free WiFi. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Santa Cruz Plaza is a top spa hotel featuring a rooftop terrace, a 24-hour fitness center, a free kid's club, and a bar. Treat yourself to a facial, body scrub, or hydrotherapy at the onsite spa. Other popular spa hotels in Santa Cruz include Hotel Cava Colchagua and Hostal Vida 2000. See all spa hotels in Santa Cruz.
What is the best accommodation for staying close to Arturo Merino Benitez Airport (SCL)?
Holiday Inn Santiago - Airport Terminal is a popular 3.5-star hotel featuring free extended parking and a restaurant. It's located a short 0.1 mi (0.2 km) from Arturo Merino Benitez Airport. Other good choices near the airport include Hotel Diego de Almagro Aeropuerto - Santiago and City Express Santiago Aeropuerto.
What's it like to stay in Santa Cruz?
Visitors to Santa Cruz are sure to enjoy the wineries, local tours, and restaurants. Tourists can also enjoy so much more including its casinos. In Santa Cruz, there are 32 hotels and other accommodations to choose from. Find out more about Santa Cruz.
What should I do while I'm visiting Santa Cruz?
Wine tasting is a great activity, and Bodega Viña Viu Manent is one place to visit. A couple of additional sights to add to your agenda are Museo de Colchagua and Casino Colchagua. Check out what more to see and do in Expedia's Santa Cruz guide.
What's the seasonal weather like in Santa Cruz?
The hottest months are usually January and February with an average temp of 70°F, while the coldest months are July and August with an average of 50°F. Average annual precipitation for Santa Cruz is 29 inches.

Explore a world of travel with Expedia