Chile may have travel restrictions in place due to COVID-19.

Find out moreOpens in new tab or window
Vivian Rennó on trover

Find Hotels in Santa Cruz

Search over 1 million properties and 550 airlines worldwide

Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.

Free cancellation on most hotels. Because flexibility matters.

Filter by

Popular Filters
Star rating
Your Budget
Guest rating
Payment Type
Property Type
Neighborhood
Popular Locations
Amenities
Accessibility
Trip Type
Santa Cruz Plaza
4 out of 5
Plaza De Armas 286, Santa Cruz, O'Higgins
The price is ¥16,816 per night
0.04 km from city center
4.3/5Excellent! (171 reviews)
When in wine country, stay in Santa Cruz Plaza

"Great character and super location. The rooms were comfortable. The La Palapa was a great place to have a casual dinner. Breakfast buffet was very bountiful and tasty. The vineyards in the area are fantastico!!"…"

Reviewed on Mar 9, 2020

Santa Cruz Plaza
Hotel Raices de Colchagua
2.5 out of 5
Ruta I-710 Isla de Yaquil s/n, Santa Cruz, O'Higgins
Get Rates
7.66 km from city center
Hotel Raices de Colchagua
Hostal Cepa Noble
3 out of 5
Alberto Edwards 205, Santa Cruz
Get Rates
0.56 km from city center
4.7/5Exceptional! (6 reviews)
Excelente para estadías cortas

"Súper amabilidad de las personas, especialmente en el desayuno. Debieran mejorar el baño, aparente filtración que provoca olor a humedad en toda la habitación."…"

Reviewed on Dec 19, 2019

Hostal Cepa Noble

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
Hotel Cava Colchagua
2.5 out of 5
Barreales´s Way, 3km from Santa Cruz Square, Santa Cruz, O'Higgins
The price is ¥15,758 per night
2.73 km from city center
4.4/5Wonderful! (82 reviews)
Quaint and relaxing hotel in Santa Cruz

"The place is great, unique, and relaxing. The service was generally good, except with a special request for a birthday cake."…"

Reviewed on Jan 30, 2020

Hotel Cava Colchagua
Callihue de Colchagua Lodge
3 out of 5
San Pedro de Callihue lote 15, Camino Lolol, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is ¥11,634 per night
8.94 km from city center
Callihue de Colchagua Lodge
La Ruta del Jazz
2.5 out of 5
Villa Yucatan, 222, Santa Cruz
Get Rates
0.41 km from city center
La Ruta del Jazz
Hostal Petit Verdot
3 out of 5
Orlando Días Besoain 419, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is ¥7,403 per night
0.52 km from city center
Hostal Petit Verdot
Hostal Vida 2000
2.5 out of 5
Ismael Valdes 245, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is ¥4,125 per night
0.71 km from city center
2/5 (1 review)

"me cobraron 35000 por una noche siendo que cuando reserve decia 22500 mas o menos mas iva ...no respetan la reserva"…"

Reviewed on Oct 22, 2019

Hostal Vida 2000
Whay Hau
3 out of 5
Avenida Errázuriz 625, Santa Cruz, O'Higgins
Get Rates
0.76 km from city center
3.3/5 (6 reviews)

"The staff were friendly and helpful (and patient) with us not speaking Spanish and them only speaking Spanish. Parking required guests (or staff) to move cars to let other people leave so an early departure could be a problem."…"

Reviewed on Mar 9, 2020

Whay Hau
La Perla Hotel
3.5 out of 5
El Rosal, Parcela 4, Lote A, Capellanía, Santa Cruz, O'Higgins
The price is ¥10,312 per night
1.59 km from city center
4.7/5Exceptional! (47 reviews)

"La Perla made our visit to Santa Cruz and the surrounding wine region a delight. The hotel grounds we beautiful and the hotel was spotless! Great service at front desk with efficient help in setting up winery visit, dining reservations and horseback rides. We would without a doubt use La Perla ..."…"

Reviewed on Feb 24, 2020

La Perla Hotel
TerraViña
3 out of 5
Camino Los Boldos S/n, Santa Cruz, O'Higgins
Get Rates
2 km from city center
4.6/5Exceptional! (125 reviews)

"Lovely setting and serenity about the accommodation. Good restaurants close by (walkable) and friendly staff allowed early check-in."…"

Reviewed on Mar 17, 2020

TerraViña
Barrica Lodge
3.5 out of 5
Camino La Villa s/n, Santa Cruz, Colchagua
Get Rates
6.93 km from city center
4.8/5Exceptional! (24 reviews)

"This place is amazing! An oasis coming close to what paradise might look like! Great place to enjoy and realax in Prados"…"

Reviewed on Feb 7, 2020

Barrica Lodge
Intown Apart Santa Cruz
2.5 out of 5
Claudio Cancino 92, Santa Cruz, O'Higgins
Get Rates
0.17 km from city center
5/5Exceptional! (1 review)
Boa experiência

"A experiência no Check In foi muito boa. Mário, quem nos atendeu, foi muito cordial e como estavamos chegando de Pucon (12h de viagem) cheguei às 9h da manhã. Assim mesmo, ele nos proporcionou a antecipação do apartamento para descansarmos. O prédio é novo e o quarto estava em excelentes condições: ..."…"

Reviewed on Sep 26, 2017

Intown Apart Santa Cruz
Tierra y Vino
3 out of 5
162 5 de Abril, Santa Cruz, O'Higgins
The price is ¥7,720 per night
0.2 km from city center
Tierra y Vino
Hostal Buon Suonno
2.5 out of 5
Los libertadores 151, Santa Cruz
Free CancellationReserve now, pay when you stay
The price is ¥6,874 per night
0.25 km from city center
Hostal Buon Suonno
Don't see what you're looking for?
See all available properties in Santa Cruz
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santa Cruz Hotel Guide

Search for hotels in Santa Cruz on Expedia. You can easily find your hotels in Santa Cruz using one of the methods below:

  • View our selection of featured hotels in Santa Cruz
  • Use the map to find hotels in the Santa Cruz neighborhood you prefer
  • Use the filters to see hotels in a specific area of Santa Cruz, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Santa Cruz
  • Enter your travel dates to view the best deals on hotels in Santa Cruz - while they last

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Based on our traveler data, Santa Cruz Plaza is one of the top choices for your stay. This 4-star hotel offers a full-service spa and a restaurant. Other good choices for your trip include Hotel Raices de Colchagua and Hostal Cepa Noble.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! You’ll find that most hotel bookings are refundable if you cancel prior to the hotel’s cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and receive a refund within 24 hours of booking. Enter your dates, click on “Search”, then filter by “free cancellation” to view the best options available in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
To access more information about changing or cancelling your trip to Santa Cruz, head over to our customer service page.
What's the best hotel for families in Santa Cruz?
Hotel Boutique Solaz Bella Vista de Colchagua is a top 3-star hotel on Expedia for families, and features an outdoor pool and free parking. Other choices for your family trip include Hotel Boutique Vendimia Premium and Santa Cruz Plaza.
What's the best accommodation for a romantic getaway to Santa Cruz?
Santa Cruz Plaza is a favorite 4-star hotel for couples, and features a full-service spa and a poolside bar. Other good choices for a stay with your sweetheart include Hotel Boutique Vendimia Premium and Hotel Cava Colchagua.
What's the best pet-friendly place to stay in Santa Cruz?
Hotel Hoja de Parra is a top hotel for people traveling with their pets, and offers a restaurant and a seasonal outdoor pool for its human guests.
Where is the best place to stay close to Lapostolle Clos Apalta Winery?
Hotel Cava Colchagua is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and free breakfast. It’s located 4.7 mi (7.6 km) from Lapostolle Clos Apalta Winery. Other good options within 5 miles include Hotel Casa de Campo and Hotel Hoja de Parra.
What about the best place to stay close to Museo de Colchagua?
One of the top choices for your stay is Santa Cruz Plaza, located next to Museo de Colchagua, and this 4-star hotel offers a full-service spa and free breakfast. Casa Calfu Hostal Bed and Breakfast and Hotel Boutique Vendimia Premium are two other good choices in the immediate area.
What's the best boutique-style hotel in Santa Cruz?
Hotel Boutique Vendimia Premium is a favorite 3.5-star hotel with Expedia travelers looking for a stylish accommodation, featuring a poolside bar and a seasonal outdoor pool.
What's the best accommodation for casino gaming in Santa Cruz?
La Perla Hotel is a top 3.5-star hotel featuring a casino shuttle and free breakfast. Other good options near the gaming action include Hotel Boutique Vendimia Premium and Santa Cruz Plaza.
What are some accommodations with pools in Santa Cruz?
Hotel Boutique Solaz Bella Vista de Colchagua is a popular 3-star hotel featuring an outdoor pool, a full-service spa, and free breakfast. A couple of other options that offer an onsite pool include TerraViña and Santa Cruz Plaza.

Recent reviews of Santa Cruz hotels

More trip options