Find Luxury Hotels in Santa Cruz de la Sierra

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Check availability on Santa Cruz de la Sierra Luxury Hotels

Tonight
Dec 23 - Dec 24
Tomorrow
Dec 24 - Dec 25
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Our top choices for Santa Cruz de la Sierra luxury hotels

Ballroom
Hotel Izan Trujillo

Hotel Izan Trujillo

Hotel Izan Trujillo
4.0 star property
Trujillo
8.8 out of 10, Excellent, (209)
"We enjoyed our stay, albeit just for one night. Nice hotel. Totally recommend. "
United Kingdom
Younes
The price is ￥11,392
￥12,531 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hotel Izan Trujillo
Exterior
Eurostars Palacio Santa Marta

Eurostars Palacio Santa Marta

Eurostars Palacio Santa Marta
4.0 star property
Trujillo
9.2 out of 10, Wonderful, (327)
"Just excellent, Service from all staff is perfect "
Mexico
Jor
The price is ￥10,907
￥11,998 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Eurostars Palacio Santa Marta
Exterior
Parador de Trujillo

Parador de Trujillo

Parador de Trujillo
4.0 star property
Trujillo
9.2 out of 10, Wonderful, (224)
"Very nice hotel, good parking, well located, "
United States
Edgar
The price is ￥11,934
￥13,127 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Parador de Trujillo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz de la Sierra Hotel Reviews

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Santa Cruz de la Sierra?
Amenities are important when you plan a trip, so we make it easy to find what you need to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Santa Cruz de la Sierra has to offer.
When can I expect good weather in Santa Cruz de la Sierra?
Planning for the weather is an important factor for making your trip to Santa Cruz de la Sierra a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 47°F. Average annual precipitation for Santa Cruz de la Sierra is 22 inches.
What's there to see and do in Santa Cruz de la Sierra?
When you're in Santa Cruz de la Sierra, enjoy exploring the sights and attractions here including Juan Pizarro de Orellana Palace, City Walls, and Plaza Mayor. If you have spare time during your trip, you might want to make a stop at Trujillo Castle and Museo de Vino y Queso.