Santa Clara Vacations from ¥1,231,226

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The Latest Santa Clara Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hyatt Regency Panama City
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá
Hotel Riu Plaza Panama
Casa Mallet by Wynwood House

Find the Best Santa Clara Vacation Packages

Santa Clara Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ¥21,869 per night from Sep 2 to Sep 3
¥21,869
¥24,056 total
Sep 2 - Sep 3
includes taxes & fees
Hotel Riu Plaza Panama
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ¥25,967 per night from Sep 2 to Sep 3
¥25,967
¥28,564 total
Sep 2 - Sep 3
includes taxes & fees
9.2/10 Wonderful! (1,010 reviews)
"Vert pretty hotel with a great location. A lot of stores, bars and restaurants around."

Reviewed on Aug 3, 2026

Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
The price is ¥32,949 per night from Aug 28 to Aug 29
¥32,949
¥36,244 total
Aug 28 - Aug 29
includes taxes & fees
8.4/10 Very Good! (1,629 reviews)
"La habitación es muy amplia y siempre limpia. Algunas personas del staff de reservaciones no fueron de mucha ayuda pero hay otra gente en el día final de nuestra estadía que si nos ayudaron muy amablemente. A la hora del check in la información sobre el hotel y ciertos detalles importantes como donde ..."

Reviewed on Aug 3, 2026

Megapolis Hotel Panamá
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Clara attractions

What to do in Santa Clara

Frequently asked questions

How much does a Santa Clara vacation package cost?
You can snap up a vacation package to this destination from ¥1,231,226 on Expedia. However, how much your vacation to Santa Clara costs will depend on your hotel choice, season and length of stay.
What are the cheapest months to go to Santa Clara?
If you're hoping to snag a cheap Santa Clara vacation package, consider traveling in September, October and November. You're likely to find lower rates on accommodations and flights during these quieter months — ideal for a budget-friendly break.
How many days is enough for Santa Clara?
With a well-organized travel plan, you can easily tick off the top Santa Clara attractions in a few days. But if you prefer to discover hidden spots or go on day trips, think about booking your Santa Clara vacation for longer.
How to find the best Santa Clara package deals?
Landing a cheap Santa Clara package deal is easy with Expedia. After you've entered your preferred dates and destination under our "Packages" tab, set your maximum budget, add a few filters and browse what's available. You can tweak your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most affordable Santa Clara package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are generally lower.
Is it cheaper to book a Santa Clara vacation as a package?
An Expedia vacation package could land you significant savings when compared to arranging flights and stays separately. Better still, you can customize your Santa Clara trip to fit your exact style. Choose your preferred flight time, select the hotel type and add a rental car. Check out our great deals to see how much you can save.
When to book a vacation package to Santa Clara?
If you have your Santa Clara vacation dates finalized, book as early as you can to bag some incredible deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spontaneous getaways? Our last-minute deals are perfect for quick escapes.
How to plan a trip to Santa Clara?

  1. Choose when to go: Check your schedule and get your bags packed. Your favorite time of year and the available activities will also help you decide when to escape to Santa Clara.
  2. Set a budget: Factor in costs like flights, meals and transportation when calculating how much to set aside for your trip to Santa Clara. Then, pick a hotel that matches your budget, whether that's an economical option or a lavish retreat.
  3. Decide how many days away: Start by listing all the activities and attractions you want to experience in Santa Clara. Then, estimate how long you'll need at each, as well as any travel time.
  4. Combine your airfare and accommodations: Once you've nailed down your travel dates and duration, book the perfect Santa Clara vacation package for you.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.