Find hotels in Santa Clara from ￥8,556

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 3 - Dec 4
Tomorrow
Dec 4 - Dec 5
This weekend
Dec 5 - Dec 7
Next weekend
Dec 12 - Dec 14

Filter by

Guest rating
Guest rating
Star rating

Compare 1,659 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

47-inch flat-screen TV with cable channels, TV
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4.0 star property
Casco Viejo
9.0 out of 10, Wonderful, (1001)
"Hotel was beautiful, staff was very helpful and accommodating. We had the pool two separate days to ourselves. Breakfadt was very good. Staff was very helpful getting us drivers wherever we wanted to go in the city."
United States
MICHELE
Central Hotel Panama Casco Viejo
Front of property
La Concordia Boutique Hotel

La Concordia Boutique Hotel

4.0 star property
Casco Viejo
9.6 out of 10, Exceptional, (194)
"The staff was very friendly and supportive. The room was spectacular! It was beautifully decorated and very clean. It was just a delight to stay in this lovely hotel!"
United States
Madelaine
La Concordia Boutique Hotel
Reception
Hotel Coral Suites

Hotel Coral Suites

3.5 star property
Bella Vista
9.0 out of 10, Wonderful, (1006)
"Great place for the price. "
United States
Ryan
The price is ￥10,795
￥11,874 total
includes taxes & fees
Dec 6 - Dec 7
Hotel Coral Suites
View from property
Waldorf Astoria Panama

Waldorf Astoria Panama

5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1011)
"I loved everything about my stay "
United States
Stephanie
The price is ￥27,935
￥30,729 total
includes taxes & fees
Dec 18 - Dec 19
Waldorf Astoria Panama
3 outdoor pools, pool umbrellas, sun loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5.0 star property
Veracruz
8.0 out of 10, Very Good, (1013)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is ￥25,908
￥28,499 total
includes taxes & fees
Dec 16 - Dec 17
The Westin Playa Bonita Panama
Exterior
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

3.5 star property
Bella Vista
9.2 out of 10, Wonderful, (1018)
"Staff was helpful, room was clean and I enjoyed my stay. "
United States
Lystra
The price is ￥12,414
￥13,655 total
includes taxes & fees
Jan 2 - Jan 3, 2026
TRYP by Wyndham Panamá Centro
Outdoor pool, open 7:00 AM to 10:30 PM, free cabanas, pool umbrellas
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4.0 star property
Tocumen
8.6 out of 10, Excellent, (1856)
"I love the included shuttle and breakfast and how close it is to the airport"
United States
leon
The price is ￥19,453
￥21,398 total
includes taxes & fees
Dec 29 - Dec 30
Riande Aeropuerto Hotel & Casino
Aerial view
Gamboa Rainforest Reserve

Gamboa Rainforest Reserve

3.5 star property
Colon
7.8 out of 10, Good, (660)
"We had a lovely stay, the views and tranquility of the place was my favorite part."
United States
Rebecca
The price is ￥15,959
￥17,905 total
includes taxes & fees
Dec 14 - Dec 15
Gamboa Rainforest Reserve
Front of property - evening/night
Principe Hotel and Suites

Principe Hotel and Suites

3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1590)
"Great hotel, location, food. Highly recommend the sushi restaurant next door.. One of the best ever. "
United States
Lakshmin
The price is ￥7,778
￥8,556 total
includes taxes & fees
Dec 20 - Dec 21
Principe Hotel and Suites
Outdoor pool
Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina

3.0 star property
Bella Vista
7.4 out of 10, Good, (267)
"Hotel staff and rooms were good , great location "
United States
Cornelly
The price is ￥9,268
￥10,195 total
includes taxes & fees
Dec 16 - Dec 17
Ramada Panama Centro Via Argentina
Exterior
Aloft Panama

Aloft Panama

3.5 star property
San Francisco
8.8 out of 10, Excellent, (889)
"The staff was very friendly, rooms were clean and modern."
United States
Greg
The price is ￥17,190
￥18,909 total
includes taxes & fees
Dec 22 - Dec 23
Aloft Panama
Front of property
Novotel Panama City

Novotel Panama City

4.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1026)
"Room very clean, nice staffs and good location "
United States
Hayden
The price is ￥14,300
￥15,730 total
includes taxes & fees
Dec 9 - Dec 10
Novotel Panama City
Couples treatment rooms, sauna, steam room, body treatments
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1010)
"Love this hotel. Busy area, but hotel and restaurant make up for it."
United States
Allen
The price is ￥28,241
￥31,065 total
includes taxes & fees
Dec 19 - Dec 20
Bristol Panama, a Registry Collection Hotel
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (634)
"Beautiful property. Excellent lunch, fish tacos were amazing. "
United States
Marc
The price is ￥29,090
￥31,999 total
includes taxes & fees
Dec 6 - Dec 7
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Outdoor pool, open 9:00 AM to 9:00 PM, sun loungers
Hospedium Princess Hotel Panama

Hospedium Princess Hotel Panama

3.5 star property
Bella Vista
7.6 out of 10, Good, (689)
"The breakfast was great, I love the pool."
United States
Estefani
The price is ￥8,635
￥9,499 total
includes taxes & fees
Dec 4 - Dec 5
Hospedium Princess Hotel Panama
Breakfast, lunch, dinner served; international cuisine
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1018)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
The price is ￥17,057
￥18,763 total
includes taxes & fees
Dec 24 - Dec 25
Courtyard by Marriott Panama Metromall
Daily full breakfast for a fee
Hotel La Compañía Casco Antiguo

Hotel La Compañía Casco Antiguo

4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (256)
"Many shops and restaurants nearby and the hotel is located in a beautiful area "
United States
Jerry
The price is ￥50,181
￥55,199 total
includes taxes & fees
Dec 23 - Dec 24
Hotel La Compañía Casco Antiguo
Private kitchen
Mahogany Suites

Mahogany Suites

2.0 star property
Rousseau
10.0 out of 10, Exceptional, (1)
"Todo ok"
Colombia
Juan
The price is ￥14,175
￥15,593 total
includes taxes & fees
Dec 26 - Dec 27
Mahogany Suites
Front of property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 star property
San Francisco
8.4 out of 10, Very Good, (1242)
"Its a very beautiful hotel with view and very good breakfast "
United States
Patrick
The price is ￥21,529
￥23,682 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Megapolis Hotel Panamá
Outdoor pool, sun loungers
Hampton by Hilton Panama

Hampton by Hilton Panama

3.0 star property
Bella Vista
7.8 out of 10, Good, (1008)
"The hotel is good for the price , the lobby didn’t have any air conditioning,also the rooms where clean but needed to be updated , the breakfast buffet had multiple choices and it was very good . The hotel is in great location near walking distance to restaurants and stores . I will stay again. "
United States
Yusneilys amores
The price is ￥11,215
￥12,337 total
includes taxes & fees
Dec 12 - Dec 13
Hampton by Hilton Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Santa Clara attractions

Culebra Cut

You can find out about the history of Santa Clara with a visit to Culebra Cut. Check out the casinos and top-notch restaurants in this walkable area.
See properties

Learn more about Santa Clara

Santa Clara awaits: its natural setting, monuments, history, and more!

See all hotels in Santa Clara
Adobe

Top Santa Clara Hotel Reviews

Megapolis Hotel Panamá

Megapolis Hotel Panamá

10/10 Excellent
"Good location"
Ruslan 3-night trip
Posted 2 days ago
Megapolis Hotel Panamá

More cheap stays in Santa Clara

Arcadia Condo Suites

Arcadia Condo Suites

Calle rio mar Panama City Panamá Province
The price is ￥10,592 per night from Dec 16 to Dec 17
￥10,592
￥18,847 total
Dec 16 - Dec 17
includes taxes & fees
9.2/10 Wonderful! (143 reviews)

Frequently asked questions

What's the best place for a stay in Santa Clara?
Located 15.8 mi (25.5 km) from the heart of Santa Clara, Hotel Riu Plaza Panama is a top choice for your stay based on our traveler data. Two other choices for your stay in the area are Las Americas Golden Tower Panama and Waldorf Astoria Panama. See all available top hotels, or vacation rentals in Santa Clara.
What's the top vacation rental in Santa Clara?
Panama View House – A Hilltop Retreat with Stunning Canal Views: This vacation home rental outside of Santa Clara has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. See all vacation rentals in Santa Clara.
If I need to cancel my hotel reservation in Santa Clara, will I receive a refund?
Yes! The majority of hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Clara.
Where can I learn more about changing or cancelling my trip to Santa Clara?
To access more information about rescheduling or cancelling your trip to Santa Clara, go to https://www.expedia.com/service/.
What's the best place to stay near Culebra Cut?
Gamboa Rainforest Reserve is one of the top choices for your stay based on our traveler data, and this 3.5-star hotel offers a marina and a full-service spa. It's located 2.9 mi (4.7 km) from Culebra Cut. Other good options within 5 miles include Canopy Bed & Breakfast and Casa en Gamboa al lado Canal de Panama.
What is staying in Santa Clara like?
Visitors can enjoy all that Santa Clara has to offer including its monuments. A top sight in the area is Albrook Shopping Mall. There are 1611 hotels and other accommodations in the surrounding area. Find out more about Santa Clara.
What is there to see in Santa Clara?
A favorite place to visit is Culebra Cut. Additionally, you'll find Albrook Shopping Mall in the area. Check out what more to see and do in Expedia's Santa Clara guide.
What's the seasonal weather like in Santa Clara?
The hottest months are usually April and March with an average temp of 79°F, while the coldest months are January and February with an average of 78°F. The rainiest months in Santa Clara are July, August, November, and October, with each month seeing an average of 11 inches of rainfall.

Explore a world of travel with Expedia