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Compare 1,659 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Central Hotel Panama Casco Viejo

4.0 star property
Casco Viejo
9.0 out of 10, Wonderful, (1001)
"Hotel was beautiful, staff was very helpful and accommodating. We had the pool two separate days to ourselves. Breakfadt was very good. Staff was very helpful getting us drivers wherever we wanted to go in the city."
United States
MICHELE
Central Hotel Panama Casco Viejo

La Concordia Boutique Hotel

4.0 star property
Casco Viejo
9.6 out of 10, Exceptional, (194)
"The staff was very friendly and supportive. The room was spectacular! It was beautifully decorated and very clean. It was just a delight to stay in this lovely hotel!"
United States
Madelaine
La Concordia Boutique Hotel

Hotel Coral Suites

3.5 star property
Bella Vista
9.0 out of 10, Wonderful, (1006)
"Great place for the price. "
United States
Ryan
The price is ¥10,795
¥11,874 total
includes taxes & fees
Dec 6 - Dec 7
Hotel Coral Suites

Waldorf Astoria Panama

5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1011)
"I loved everything about my stay "
United States
Stephanie
The price is ¥27,935
¥30,729 total
includes taxes & fees
Dec 18 - Dec 19
Waldorf Astoria Panama

The Westin Playa Bonita Panama

5.0 star property
Veracruz
8.0 out of 10, Very Good, (1013)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is ¥25,908
¥28,499 total
includes taxes & fees
Dec 16 - Dec 17
The Westin Playa Bonita Panama

TRYP by Wyndham Panamá Centro

3.5 star property
Bella Vista
9.2 out of 10, Wonderful, (1018)
"Staff was helpful, room was clean and I enjoyed my stay. "
United States
Lystra
The price is ¥12,414
¥13,655 total
includes taxes & fees
Jan 2 - Jan 3, 2026
TRYP by Wyndham Panamá Centro

Riande Aeropuerto Hotel & Casino

4.0 star property
Tocumen
8.6 out of 10, Excellent, (1856)
"I love the included shuttle and breakfast and how close it is to the airport"
United States
leon
The price is ¥19,453
¥21,398 total
includes taxes & fees
Dec 29 - Dec 30
Riande Aeropuerto Hotel & Casino

Gamboa Rainforest Reserve

3.5 star property
Colon
7.8 out of 10, Good, (660)
"We had a lovely stay, the views and tranquility of the place was my favorite part."
United States
Rebecca
The price is ¥15,959
¥17,905 total
includes taxes & fees
Dec 14 - Dec 15
Gamboa Rainforest Reserve

Principe Hotel and Suites

3.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1590)
"Great hotel, location, food. Highly recommend the sushi restaurant next door.. One of the best ever. "
United States
Lakshmin
The price is ¥7,778
¥8,556 total
includes taxes & fees
Dec 20 - Dec 21
Principe Hotel and Suites

Ramada Panama Centro Via Argentina

3.0 star property
Bella Vista
7.4 out of 10, Good, (267)
"Hotel staff and rooms were good , great location "
United States
Cornelly
The price is ¥9,268
¥10,195 total
includes taxes & fees
Dec 16 - Dec 17
Ramada Panama Centro Via Argentina

Aloft Panama

3.5 star property
San Francisco
8.8 out of 10, Excellent, (889)
"The staff was very friendly, rooms were clean and modern."
United States
Greg
The price is ¥17,190
¥18,909 total
includes taxes & fees
Dec 22 - Dec 23
Aloft Panama

Novotel Panama City

4.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1026)
"Room very clean, nice staffs and good location "
United States
Hayden
The price is ¥14,300
¥15,730 total
includes taxes & fees
Dec 9 - Dec 10
Novotel Panama City

Bristol Panama, a Registry Collection Hotel

5.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1010)
"Love this hotel. Busy area, but hotel and restaurant make up for it."
United States
Allen
The price is ¥28,241
¥31,065 total
includes taxes & fees
Dec 19 - Dec 20
Bristol Panama, a Registry Collection Hotel

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (634)
"Beautiful property. Excellent lunch, fish tacos were amazing. "
United States
Marc
The price is ¥29,090
¥31,999 total
includes taxes & fees
Dec 6 - Dec 7
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Hospedium Princess Hotel Panama

3.5 star property
Bella Vista
7.6 out of 10, Good, (689)
"The breakfast was great, I love the pool."
United States
Estefani
The price is ¥8,635
¥9,499 total
includes taxes & fees
Dec 4 - Dec 5
Hospedium Princess Hotel Panama

Courtyard by Marriott Panama Metromall

4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1018)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
The price is ¥17,057
¥18,763 total
includes taxes & fees
Dec 24 - Dec 25
Courtyard by Marriott Panama Metromall

Hotel La Compañía Casco Antiguo

4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (256)
"Many shops and restaurants nearby and the hotel is located in a beautiful area "
United States
Jerry
The price is ¥50,181
¥55,199 total
includes taxes & fees
Dec 23 - Dec 24
Hotel La Compañía Casco Antiguo

Mahogany Suites

2.0 star property
Rousseau
10.0 out of 10, Exceptional, (1)
"Todo ok"
Colombia
Juan
The price is ¥14,175
¥15,593 total
includes taxes & fees
Dec 26 - Dec 27
Mahogany Suites

Megapolis Hotel Panamá

4.5 star property
San Francisco
8.4 out of 10, Very Good, (1242)
"Its a very beautiful hotel with view and very good breakfast "
United States
Patrick
The price is ¥21,529
¥23,682 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Megapolis Hotel Panamá

Hampton by Hilton Panama

3.0 star property
Bella Vista
7.8 out of 10, Good, (1008)
"The hotel is good for the price , the lobby didn’t have any air conditioning,also the rooms where clean but needed to be updated , the breakfast buffet had multiple choices and it was very good . The hotel is in great location near walking distance to restaurants and stores . I will stay again. "
United States
Yusneilys amores
The price is ¥11,215
¥12,337 total
includes taxes & fees
Dec 12 - Dec 13
Hampton by Hilton Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Santa Clara awaits: its natural setting, monuments, history, and more!

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Top Santa Clara Hotel Reviews

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Frequently asked questions

What's the best place for a stay in Santa Clara?
Located 15.8 mi (25.5 km) from the heart of Santa Clara, Hotel Riu Plaza Panama is a top choice for your stay based on our traveler data. Two other choices for your stay in the area are Las Americas Golden Tower Panama and Waldorf Astoria Panama. See all available top hotels, or vacation rentals in Santa Clara.
What's the top vacation rental in Santa Clara?
Panama View House – A Hilltop Retreat with Stunning Canal Views: This vacation home rental outside of Santa Clara has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. See all vacation rentals in Santa Clara.
If I need to cancel my hotel reservation in Santa Clara, will I receive a refund?
Yes! The majority of hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Clara.
Where can I learn more about changing or cancelling my trip to Santa Clara?
To access more information about rescheduling or cancelling your trip to Santa Clara, go to https://www.expedia.com/service/.
What's the best place to stay near Culebra Cut?
Gamboa Rainforest Reserve is one of the top choices for your stay based on our traveler data, and this 3.5-star hotel offers a marina and a full-service spa. It's located 2.9 mi (4.7 km) from Culebra Cut. Other good options within 5 miles include Canopy Bed & Breakfast and Casa en Gamboa al lado Canal de Panama.
What is staying in Santa Clara like?
Visitors can enjoy all that Santa Clara has to offer including its monuments. A top sight in the area is Albrook Shopping Mall. There are 1611 hotels and other accommodations in the surrounding area. Find out more about Santa Clara.
What is there to see in Santa Clara?
A favorite place to visit is Culebra Cut. Additionally, you'll find Albrook Shopping Mall in the area. Check out what more to see and do in Expedia's Santa Clara guide.
What's the seasonal weather like in Santa Clara?
The hottest months are usually April and March with an average temp of 79°F, while the coldest months are January and February with an average of 78°F. The rainiest months in Santa Clara are July, August, November, and October, with each month seeing an average of 11 inches of rainfall.

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