San Francisco Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ￥45,448 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
Fachada colorida de estilo colonial, barrio de Santa Ana, Guayaquil, Ecuador

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

Find hotels in Ecuador

San Francisco Hotel Deals

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 out of 5
Calle Numa Pompilio Llona S N Guayaquil Guayas
Fully refundableReserve now, pay when you stay
The price is ￥15,911 per night from Apr 26 to Apr 27
￥15,911
￥17,900 total
Apr 26 - Apr 27
9.2/10 Wonderful! (1,005 reviews)
This place was great, service was top notch, they have won several prestigious hotel awards, and you can tell why the best service at a hotel I have experienced in a very long time.

Reviewed on Apr 11, 2026

Wyndham Guayaquil Puerto Santa Ana
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto Guayaquil Guayas
Fully refundable
The price is ￥14,653 per night from May 3 to May 4
￥14,653
￥16,516 total
May 3 - May 4
9.4/10 Exceptional! (1,011 reviews)
Staff was very nice

Reviewed on Apr 9, 2026

Holiday Inn Guayaquil Airport by IHG
Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno Guayaquil Guayas
Fully refundableReserve now, pay when you stay
The price is ￥12,742 per night from Apr 17 to Apr 18
￥12,742
￥14,414 total
Apr 17 - Apr 18
9.4/10 Exceptional! (1,003 reviews)
Yes, great

Reviewed on Apr 10, 2026

Oro Verde Guayaquil
See all 433 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a San Francisco vacation package cost?
From as little as . Yes, you read that right. Our San Francisco vacation packages are a simple way to make your dollars go much further. Bundle your hotels, flights and car rentals and discover this popular destination.
How do I get a cheap travel package to San Francisco?
Browse and lock in everything all in one place with our San Francisco vacation packages. We have deals on hotels, flights, tours and more that'll keep your wallet happy and your adventurous spirit busy. And, with more than 550 partner airlines and 1,000,000 properties globally to select from, you'll have endless opportunities to mix and match as you please.
How far in advance should I book my San Francisco vacation?
Search Expedia to compare airfares as soon as you know your travel dates. In many cases, you can purchase a ticket up to a year before departure. If you don't see your preferred carrier, or you have to book last minute, don't worry. The lowest prices to San Francisco occasionally appear within weeks of departure.
What does an Expedia San Francisco travel package include?
That depends on what sort of getaway you're contemplating. San Francisco travel deals can include flights, hotels and car rentals. You can mix and match to find the bundle that works for you! You can also add on experiences and activities after you've booked to get even bigger discounts.
What should I know before booking a San Francisco travel package?
So many places to travel to, so many things to see. With a package, you'll be able to cross more of them off your list. Combine your hotels, rental cars and flights and see how much you save.
Can I choose my airline with a San Francisco Expedia vacation package?
Yes, you can. We have more than 550 partner airlines worldwide, so fly with the carrier that best suits your travel preferences.
If I'm not able to travel, can I cancel my San Francisco vacation package?
Certainly, and we're here to help. You may be able to cancel and rebook your San Francisco vacation package at no cost if you booked in the last 24 hours. However, you may be charged a fee by your airline, hotel or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, browse our Customer Service Portal for more information.

Things to do

City Winery - Two Hemispheres

Wine Tasting Experience with Tasting Menu

￥10,236
per adult
100% of travellers recommend
Wine Tasting Experience with Tasting Menu
Best of Guayaquil - City Tour

Premium City Tour for Seniors - Guayaquil

￥23,804
per adult
Premium City Tour for Seniors - Guayaquil
Cocoa farm and Chocolate making!

Cocoa farm and Chocolate making!

￥24,597
per adult
Cocoa farm and Chocolate making!
See all activities in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.