A densely packed urban area with numerous buildings and a prominent tower on a hill.

Find hotels in Puerto Santa Ana, Guayaquil

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,003 reviews)
"Love staying at this hotel!"
United States
Isabel
The price is ￥15,835
￥17,815 total
Nov 8 - Nov 9
Wyndham Guayaquil Puerto Santa Ana
A rooftop pool with a view of the city skyline.

2. Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (111 reviews)
"So clean and very nice people. I really recommend this facility, nice environment. My next trip lm booking in this apartment"
United States
Pedro
The price is ￥13,389
￥13,547 total
Nov 21 - Nov 22
Luxury Suites Riverfront GYE
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

3. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (66 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is ￥12,411
￥14,155 total
Nov 1 - Nov 2
River View suites Puerto Santa Ana gye
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

4. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (151 reviews)
"The facility is very unique. Staff are very friendly. We have an early flight so did not get a chance to have breakfast."
United States
Shuyi
The price is ￥8,286
￥9,387 total
Nov 20 - Nov 21
Mansión del Río
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

5. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is ￥50,372
￥56,972 total
Oct 22 - Oct 23
Hotel Río Guayas by Art Hotels Ecuador
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

6. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,003 reviews)
"Easy check in and staff very friendly"
United States
Michael
The price is ￥13,454
￥15,195 total
Nov 13 - Nov 14
Oro Verde Guayaquil
A buffet setup with various food items, a modern chandelier, and a patterned floor.

7. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (354 reviews)
"Nice restaurant. Great location. Room was a good place to rest."
United States
Hector
The price is ￥9,972
￥11,207 total
Oct 30 - Oct 31
Ibis Styles El Malecon Guayaquil
An outdoor cafe with tables and chairs, surrounded by trees and buildings.

8. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
7.6 out of 10, Good, (10 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is ￥6,660
￥6,818 total
Nov 12 - Nov 13
Fortune Hotel
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

9. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (418 reviews)
"👍"
United States
Washington
The price is ￥9,972
￥10,130 total
Oct 22 - Oct 23
Hotel Ramada
A modern bar area with a bar counter, stools, and a seating area with a table and chairs.

10. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,000 reviews)
"Todo excelente"
United States
Cristhian
The price is ￥11,111
￥12,460 total
Nov 8 - Nov 9
Wyndham Garden Guayaquil
An aerial view of a hotel with a swimming pool surrounded by lush greenery and a decorative garden.

11. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,001 reviews)
"Great location, great breakfast buffet, adjacent to Iguana park, not far from airport."
Canada
Victor
The price is ￥12,159
￥13,613 total
Oct 25 - Oct 26
Grand Hotel Guayaquil, Centro Histórico.
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

12. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,004 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is ￥12,662
￥14,166 total
Oct 31 - Nov 1
Courtyard by Marriott Guayaquil
A high-rise hotel interior with multiple floors, large windows, and modern lighting fixtures.

13. Hilton Colon Guayaquil

Hilton Colon Guayaquil
4.5 star property
Kennedy, 3.2 km from Puerto Santa Ana
8.8 out of 10, Excellent, (1,004 reviews)
"I made the reservation 30 minutes before my arrival through a 3rd party and everything went smoothly. Room was clean and The staff was very professional."
United States
Eduardo
The price is ￥15,875
￥17,859 total
Nov 1 - Nov 2
Hilton Colon Guayaquil
A reception desk with a marble top and a modern light fixture above it.

14. TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport
4.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,004 reviews)
"Great staff and amazing breakfast!"
United States
William
The price is ￥13,454
￥15,195 total
Nov 1 - Nov 2
TRYP by Wyndham Guayaquil Airport
A modern interior with a seating area, a kitchen, and a dining space.

15. Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
3.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (1,004 reviews)
"As close to the airport as you would want to be. No noise, and the pool and hot tube is great after a long travel time."
United States
Frederick
The price is ￥14,720
￥16,588 total
Nov 8 - Nov 9
Holiday Inn Guayaquil Airport by IHG
A breakfast table with various foods and a view of a park through a window.

16. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,004 reviews)
"Great for a short stay"
United States
Maria
The price is ￥8,406
￥9,779 total
Nov 21 - Nov 22
Unipark by Oro Verde Hotels
A neatly made bed with a heart-shaped arrangement of red roses, a champagne bucket, and two wine glasses on a tray.

17. San Francisco Apart Hotel

San Francisco Apart Hotel
3.0 star property
La Atarazana, 1.4 km from Puerto Santa Ana
6.6 out of 10, (26 reviews)
"Nice place, nice amenities, nice staff, we'll back! "
United States
Giovanny
The price is ￥5,540
￥5,698 total
Oct 28 - Oct 29
San Francisco Apart Hotel
A cocktail on a marble table with a pool in the background.

18. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (166 reviews)
"Excellent location and close to the airport."
United States
Martin Gerardo
The price is ￥7,284
￥7,442 total
Oct 26 - Oct 27
Hotel Patrimonial by Greenfield
A spacious indoor area with a central open space surrounded by seating arrangements and a pool.

19. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (751 reviews)
"Very helpful and accommodating airport shuttle service."
United States
Jerry
The price is ￥13,454
￥15,195 total
Oct 31 - Nov 1
Radisson Hotel Guayaquil
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

20. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (962 reviews)
"We have stayed at this hotel several times and it is consistently a good experience. Comfortable bed, good air conditioning, restaurant on site, farmacia nearby. The breakfast buffet is especially good."
United States
Bethany
The price is ￥9,115
￥10,264 total
Nov 14 - Nov 15
Hotel Palace Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Puerto Santa Ana

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A modern bar area with a bar counter, seating, and a large window.
Wyndham Guayaquil Puerto Santa Ana
4.5 star property
9.4
Exceptional
1,003 reviews
View
A rooftop pool with a view of the city skyline.
Luxury Suites Riverfront GYE
3.5 star property
9.4
Exceptional
111 reviews
View
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.
River View suites Puerto Santa Ana gye
3.0 star property
9.0
Wonderful
66 reviews
View
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.
Mansión del Río
3.5 star property
8.8
Excellent
151 reviews
View
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.
Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
10.0
Exceptional
5 reviews
View

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

Simón Bolívar might not have many top sights, but Mall del Sol Shopping Center and San Marino Mall are two attractions nearby that you can check out.

A densely packed hillside cityscape with colorful buildings and a prominent tower against a sunset sky.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

Top Puerto Santa Ana Hotel Reviews

TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport

10/10 Excellent
"Great restaurant"
Angela 1-night trip
Posted 5 hours ago
TRYP by Wyndham Guayaquil Airport

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighborhood that travelers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveler data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels will I find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 88 Puerto Santa Ana hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review top deals in Puerto Santa Ana.
Where can I learn more about changing or cancelling my trip to Puerto Santa Ana?
To access more information about updating your trip to Puerto Santa Ana or cancelling it, head over to our customer service page.
What is there to do around this Guayaquil neighborhood?
Emporium by The Point, Santa Ana Garden, and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.