Prairie Home Vacation Rentals

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Jan 9 - Jan 11
In two months
Feb 20 - Feb 22
In three months
Mar 20 - Mar 22
In four months
Apr 17 - Apr 19

Our top choices for Prairie Home vacation rentals

Interior
Unique traincar stay at the Katy Caboose!

Cottage in Hartsburg

Unique traincar stay at the Katy Caboose!
9.4 out of 10, Exceptional, (10)
"We loved the 3 taverns in town. Great vibe in a tiny town. "
United States
Dusty
The price is ￥15,444
￥27,831 total
includes taxes & fees
Dec 23 - Dec 24
Unique traincar stay at the Katy Caboose!
TV
2 Bed 1 Bath Southside Columbia 7 min to Mizzou

Apartment in Columbia

2 Bed 1 Bath Southside Columbia 7 min to Mizzou
10.0 out of 10, Exceptional, (10)
"Nice and clean apartment. Comfortable beds. Great place to stay."
United States
Paul S.
The price is ￥9,465
￥33,285 total
includes taxes & fees
Jan 6 - Jan 7, 2026
2 Bed 1 Bath Southside Columbia 7 min to Mizzou
Fridge, microwave, oven, stovetop
3 Bedroom 1 Bath Pet Friendly 5 min to MU

Vacation Home in Columbia

3 Bedroom 1 Bath Pet Friendly 5 min to MU
10.0 out of 10, Exceptional, (9)
"Very clean and cute home! Great location, close to coffee shops and restaurants. We enjoyed our stay!"
United States
Lori S.
The price is ￥11,831
￥35,651 total
includes taxes & fees
Dec 29 - Dec 30
3 Bedroom 1 Bath Pet Friendly 5 min to MU
Fridge, microwave, oven, stovetop
~A Home Away From Home~Sleeps 8~

Apartment in Columbia

~A Home Away From Home~Sleeps 8~
2.0 star property
9.2 out of 10, Wonderful, (5)
"We're going to book again this time next year."
United States
Donna T.
The price is ￥11,989
￥40,469 total
includes taxes & fees
Jan 19 - Jan 20, 2026
~A Home Away From Home~Sleeps 8~
1 bedroom, iron/ironing board, WiFi, bed sheets
Carriage House by CMU - Upper Condo - Kitchen, King Bed, 65" TV Fast WiFi & AC

Condo in Fayette

Carriage House by CMU - Upper Condo - Kitchen, King Bed, 65" TV Fast WiFi & AC
2.0 star property
10.0 out of 10, Exceptional, (11)
"This place is conveniently located near the CMU college and was a nice place to stay so I could visit my son. "
United States
Shannon H.
The price is ￥11,216
￥25,207 total
includes taxes & fees
Dec 26 - Dec 27
Carriage House by CMU - Upper Condo - Kitchen, King Bed, 65" TV Fast WiFi & AC
Interior
Como's Finest- A Home Away From Home- Sleeps 10

Apartment in Columbia

Como's Finest- A Home Away From Home- Sleeps 10
8.8 out of 10, Excellent, (5)
"Overall out stay was very nice. Pictures make the place look larger but it was nice and we had enough space. There was an issue with the upstairs toilet not flushing but they came to check it out immediately. Very nice people to work with"
United States
Melissa M.
The price is ￥12,778
￥42,252 total
includes taxes & fees
Dec 23 - Dec 24
Como's Finest- A Home Away From Home- Sleeps 10
Fridge, microwave, oven, stovetop
3-bedroom Ranch Duplex in charming Columbia with WiFi, 6 miles to Mizzou Arena

Vacation Home in Columbia

3-bedroom Ranch Duplex in charming Columbia with WiFi, 6 miles to Mizzou Arena
8.8 out of 10, Excellent, (5)
"We had a great weekend in Columbia the property was close to everything we needed. Would definitely recommend and stay again "
United States
Jason C.
The price is ￥18,930
￥49,250 total
includes taxes & fees
Jan 8 - Jan 9, 2026
3-bedroom Ranch Duplex in charming Columbia with WiFi, 6 miles to Mizzou Arena
Exterior
Step Back in Time Near The Missouri River

Cottage in Jamestown

Step Back in Time Near The Missouri River
9.8 out of 10, Exceptional, (17)
"It was very beautiful well stocked, and the owner was very mindful and considerate as to what people needed to be well accommodated and comfortable. I like that."
United States
Latonya M.
The price is ￥23,820
￥36,282 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Step Back in Time Near The Missouri River
1 bedroom, bed sheets
Cozy cabin getaway with hot-tub under stars!

Cabin in Ashland

Cozy cabin getaway with hot-tub under stars!
9.6 out of 10, Exceptional, (22)
"This cabin was great and the setting was amazing. So peaceful! I would definitely stay here again."
United States
Tom M.
The price is ￥21,296
￥37,387 total
includes taxes & fees
Dec 23 - Dec 24
Cozy cabin getaway with hot-tub under stars!
2 bedrooms, desk, free WiFi, bed sheets
Historic Cozy Apartment 1 Bedroom In Peaceful Boonville

Apartment in Boonville

Historic Cozy Apartment 1 Bedroom In Peaceful Boonville
2.0 star property
9.2 out of 10, Wonderful, (14)
"Apartment very clean & neat. Convenient location. "
United States
judith s.
The price is ￥14,056
￥32,115 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Historic Cozy Apartment 1 Bedroom In Peaceful Boonville
Outdoor dining
Near University of Missouri | Fitness Center

Condo in Columbia

Near University of Missouri | Fitness Center
2.0 star property
10.0 out of 10, Exceptional, (1)
The price is ￥17,711
￥23,269 total
includes taxes & fees
Dec 24 - Dec 25
Near University of Missouri | Fitness Center
Exterior detail
Super Close to Mizzou Condo 2 Bed 1 Bath

Apartment in Columbia

Super Close to Mizzou Condo 2 Bed 1 Bath
10.0 out of 10, Exceptional, (8)
"The property was in a very convenient location and the property owner was ver responsive.I would stay again!!"
United States
Carmen H.
The price is ￥8,676
￥31,550 total
includes taxes & fees
Dec 29 - Dec 30
Super Close to Mizzou Condo 2 Bed 1 Bath
Smart TV
3BR/1.5BA Cozy, Affordable Retreat in Columbia, 10-min from Mizzou

Vacation Home in Columbia

3BR/1.5BA Cozy, Affordable Retreat in Columbia, 10-min from Mizzou
10.0 out of 10, Exceptional, (27)
"Clean property, quiet area, amenities appeared to be brand new. Host was very responsive and we enjoyed our stay. "
United States
Kevin R.
The price is ￥13,251
￥38,598 total
includes taxes & fees
Jan 15 - Jan 16, 2026
3BR/1.5BA Cozy, Affordable Retreat in Columbia, 10-min from Mizzou
Smart TV
Comfy Home~Teal Feel~ Sleeps 8

Apartment in Columbia

Comfy Home~Teal Feel~ Sleeps 8
The price is ￥11,200
￥34,902 total
includes taxes & fees
Dec 23 - Dec 24
Comfy Home~Teal Feel~ Sleeps 8
Living area
Whispering Woods Hideaway ~ Large Home ~ 85 in TV

Vacation Home in Columbia

Whispering Woods Hideaway ~ Large Home ~ 85 in TV
2.0 star property
10.0 out of 10, Exceptional, (1)
"Clean house. Very responsive"
United States
Gary B.
The price is ￥23,032
￥70,988 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Whispering Woods Hideaway ~ Large Home ~ 85 in TV
Outdoor dining
The Katy Trail Carriage House Rocheport Mo.

Apartment in Rocheport

The Katy Trail Carriage House Rocheport Mo.
10.0 out of 10, Exceptional, (17)
"Just the cutest little apartment. It had everything we needed, in walking distance to every destination desired, and extremely clean. Description and photos were captured beautifully and met all our expectations and more. Would highly recommend. "
United States
Elly B.
The price is ￥23,663
￥38,010 total
includes taxes & fees
Dec 29 - Dec 30
The Katy Trail Carriage House Rocheport Mo.
Fridge, microwave, oven, stovetop
Katy Trail Pull Off

Vacation Home in Boonville

Katy Trail Pull Off
9.6 out of 10, Exceptional, (99)
"Great home, quiet neighborhood, and comfy beds. Perfect home for our stay and we will stay again. "
United States
Samantha H.
The price is ￥14,907
￥28,024 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Katy Trail Pull Off
Fridge, microwave, oven, stovetop
It's a Gem ! Comfy Hideaway for R & R ~ King Bed !

Vacation Home in Columbia

It's a Gem ! Comfy Hideaway for R & R ~ King Bed !
9.8 out of 10, Exceptional, (20)
"Everything was great from check in to check out. "
United States
Jason L.
The price is ￥23,032
￥52,949 total
includes taxes & fees
Jan 14 - Jan 15, 2026
It's a Gem ! Comfy Hideaway for R & R ~ King Bed !
Smart TV, fireplace
Newly Built Home w/ Fresh Design!

Vacation Home in Columbia

Newly Built Home w/ Fresh Design!
9.8 out of 10, Exceptional, (22)
"Beautiful home! Easy to get to from downtown Columbia. Not far from highway 70. "
United States
Kathy S.
The price is ￥31,518
￥53,288 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Newly Built Home w/ Fresh Design!
Lobby
Brand New Modern Downtown Condo designed by award-winning architect!

Condo in Columbia

Brand New Modern Downtown Condo designed by award-winning architect!
10.0 out of 10, Exceptional, (83)
"It was clean and very nice- close to Mizzou campus so very convenient for our stay- will stay again!"
United States
Kristin G.
The price is ￥32,181
￥54,108 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Brand New Modern Downtown Condo designed by award-winning architect!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Prairie Home Hotel Reviews

Baymont by Wyndham Columbia, MO

Baymont by Wyndham Columbia, MO

10/10 Excellent
"Everything was very clean and in working order. A pleasant room."
Teresa 1-night trip
Posted 2 days ago
Baymont by Wyndham Columbia, MO

Find out more about Prairie Home

Search for holiday rentals in Prairie Home on Expedia! You can easily find your home rentals, villas, holiday apartments in Prairie Home using one of the methods below:

  • View our selection of featured holiday rentals in Prairie Home
  • Use the map to find apartments and other holiday homes in the Prairie Home neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Prairie Home while they last

Look no further and take a look at our great range of rental properties in Prairie Home!

Frequently asked questions

Can I find a vacation rental in Prairie Home?

Yes, you can find vacation rentals close to well known attractions in Prairie Home, or you can select a secluded option if you're looking for relaxation.

What's the top vacation rental that Prairie Home has to offer?

3BR/1.5BA Cozy, Affordable Retreat in Columbia, 10-min from Mizzou: This vacation home rental near Prairie Home offers a patio, a garden, and air-conditioning to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms in addition to a kitchen with a fridge and a microwave.

What can I see and do in Prairie Home?

While exploring the area, visit family-friendly sights like Warm Springs Ranch, or get outside and enjoy nature at Shelter Gardens. California Country Club and Isle of Capri Casino are a couple of places you'll find in the larger area.

What are vacation rentals like in Prairie Home?

Vacation rentals are private properties you can stay in for a few days or a quick weekend in Prairie Home. Vacation rentals feature amenities such as hot tubs, fire pits, and patios so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can provide a sense of seclusion away from public hotel elevators and lobbies packed with people while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for a small group gathering.