Grand Isle, FL

Port St. Joe

A sunset over a body of water with a bridge in the background.

Grand Isle Hotel Deals

Comfort Suites

Comfort Suites

2.5 out of 5
264 N Tyndall Pkwy Panama City FL
The price is ￥12,169 per night from Nov 15 to Nov 16
￥12,169
￥13,151 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Comfort Suites
Comfy family friendly house, short stroll to the beach!

Comfy family friendly house, short stroll to the beach!

Cape San Blas FL
Book a stay at this family-friendly vacation home in Port St. Joe. Enjoy laundry facilities, tennis courts, and patios. Popular attractions T.H. Stone Memorial ...
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Comfy family friendly house, short stroll to the beach!
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

2.5 out of 5
5627 E Highway 22 State Route Panama City FL
The price is ￥13,296 per night from Nov 15 to Nov 16
￥13,296
￥14,369 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South

2.5 out of 5
3951 E Highway 98 Port St. Joe FL
The price is ￥18,506 per night from Nov 15 to Nov 16
￥18,506
￥20,727 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this business-friendly hotel in Port St. Joe. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (789 reviews)
"it was nice staying there and the rooms was cleaning"

Reviewed on Oct 20, 2026

MainStay Suites Port Saint Joe South
Extended Stay America Select Suites - Panama City - Callaway

Extended Stay America Select Suites - Panama City - Callaway

2.5 out of 5
902 N Tyndall Parkway Panama City FL
The price is ￥10,975 per night from Nov 1 to Nov 2
￥10,975
￥11,860 total
Nov 1 - Nov 2
includes taxes & fees
Stay at this hotel in Panama City. Enjoy free WiFi, free parking, and laundry facilities. Popular attractions Southwood Shopping Center and Saint Andrews Shopping ...
Extended Stay America Select Suites - Panama City - Callaway
Coastal 3 BR Townhome overlooking St. Joe Bay

Coastal 3 BR Townhome overlooking St. Joe Bay

Port St. Joe FL
Book a stay at this family-friendly vacation home in Port St. Joe. Enjoy a garden, laundry facilities, and patios. Popular attractions Windmark Beach and Saint ...
9.8/10 Exceptional! (21 reviews)
"I can’t express how fantastic of a host Dustin and Nicole were as well as how perfect their unit is. I highly recommend this to anyone traveling to Port Saint Joe. You will not be disappointed!"

Reviewed on Oct 21, 2026

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Coastal 3 BR Townhome overlooking St. Joe Bay
See all 2,291 properties in Grand Isle
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Grand Isle

Find the best Grand Isle areas and neighborhoods for the activities you enjoy most.
A marina at sunset with boats docked and a wooden pier.
Photo by Russell Hewatt
Open Photo by Russell Hewatt

Downtown Port St. Joe

While visiting Downtown Port St. Joe, you might make a stop by sights like Port Saint Joe City Hall and Constitution Convention Museum State Park.

A white house with a black roof, a white lighthouse with a black top, and a calm lake with purple flowers in the foreground.

Cape Breezes

While Cape Breezes isn't home to many top sights, T.H. Stone Memorial St. Joseph Peninsula State Park and St. Joseph Peninsula State Park are some notable places to visit nearby.

A beach with driftwood formations at sunset.

Gulf Aire

While Gulf Aire isn't home to many top sights, Saint Joe Beach and Mexico Beach are some notable places to visit nearby.

A sandy beach with calm waters and a large cloud in the sky.

Waterside Village

Though Waterside Village might not have many top sights, you can venture to the surrounding area to see attractions like Mexico Beach Marina and Mexico Beach.

A coastal landscape with tall grasses, a palm tree, and a sunset over the water.

Palms

While there might not be top attractions in Palms, you can explore the larger area and discover places like Mexico Beach and Mexico Beach Marina.

Grand Isle, FL