Grand Isle Vacations

Book a Hotel + Flight or Car together to unlock savings

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    Better together
    Save up to ￥45,448 when you book a flight and hotel together*
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    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
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    Rest easy
    Plan, book, and manage your trip all in one place

Where to stay in Grand Isle

Find the best Grand Isle areas and neighborhoods for the activities you enjoy most. Learn more about Grand Isle
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Downtown Port St. Joe

While visiting Downtown Port St. Joe, you might make a stop by sights like Port Saint Joe City Hall and Port St. Joe Marina.

Find hotels in Downtown Port St. Joe

Grand Isle Hotel Deals

Days Inn by Wyndham Panama City/Callaway
Days Inn by Wyndham Panama City/Callaway
2 out of 5
435 North Tyndall Parkway, Hwy 98 & Hwy 22, Panama City, FL
Fully refundableReserve now, pay when you stay
The price is ￥10,205 per night from Jun 30 to Jul 1
￥10,205
￥11,028 total
Jun 30 - Jul 1
includes taxes & fees
6.6/10 (421 reviews)
"This hotel is probably a 6/10. No complaints, other than loud music in the parking lot. Overall adequate accommodations for the price."

Reviewed on Jun 25, 2025

Days Inn by Wyndham Panama City/Callaway
Extended Stay America Select Suites - Panama City - Callaway
Extended Stay America Select Suites - Panama City - Callaway
2.5 out of 5
902 N Tyndall Parkway, Panama City, FL
Fully refundableReserve now, pay when you stay
The price is ￥11,059 per night from Jun 29 to Jun 30
￥11,059
￥11,951 total
Jun 29 - Jun 30
includes taxes & fees
6.2/10 (458 reviews)
"It was great"

Reviewed on Jun 15, 2025

Extended Stay America Select Suites - Panama City - Callaway
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
2.5 out of 5
5627 E Highway 22 State Route, Panama City, FL
Fully refundable
The price is ￥20,530 per night from Jul 14 to Jul 15
￥20,530
￥22,188 total
Jul 14 - Jul 15
includes taxes & fees
8.4/10 Very Good! (412 reviews)
"Love the property thiss is my 2nd time stayimg there and i love it"

Reviewed on Jun 19, 2025

Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
See all 2,135 properties in Grand Isle
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Grand Isle vacation package cost?
We make it simple to travel the world, with Grand Isle packages starting from just . You'll have the flexibility to bundle your preferred airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Grand Isle?
Booking a Grand Isle vacation package with Expedia is one of the easiest ways to save. We offer more than 550 air carriers and 1,000,000 properties throughout the world. With such a broad range to select from, you'll have no worries putting together your perfect adventure.
Where should I stay in Grand Isle?
If you're interested in visiting Mexico Beach, save yourself the stress of commuting and book a hotel nearby. It's one of the top attractions in this neighborhood.
What are the top hotels in Grand Isle?
Beautiful Fully Remodeled Home With Private Pool is one of Grand Isle's most sought-after properties. Secure a room here and you can snooze soundly knowing you're in capable hands.
How far in advance should I book my Grand Isle vacation?
It's always wise to book early. Air carriers generally advertise flight tickets around a year prior to departure, and this is an excellent opportunity to pick up some of the cheapest prices. Boss just told you to take some vacation time next month? No problem! Expedia are never short of fantastic bargains to send you off on the getaway of your dreams, at an affordable price.
What does an Expedia Grand Isle travel package include?
Flights, hotels and a reliable car for all your road trip adventures. Simply select your favorite bundle and gain access to great discounts. Once you've made your booking, add on some experiences and tours and watch your savings pile up. When it comes to crafting your Grand Isle vacation, you're in charge!
What should I know before booking a Grand Isle travel package?
A travel package can be tailored to your budget and is a great way to make your hard-earned dollars stretch further. How little or much you include is up to you. Rental cars, hotels and flights --- mix and match whatever combination works with your plans.
Can I choose my airline with a Grand Isle Expedia vacation package?
With a vacation package, you're always in charge. Whether you're eager to fly to Grand Isle in economy or first class, simply select from the available airline options. Expedia has access to more than 550 airline partners across the world.
If I'm not able to travel, can I cancel my Grand Isle vacation package?
Because we understand life can throw you a few curveballs, the answer is yes. For further information, head to our Customer Service Portal. But generally speaking, if you've booked your Grand Isle vacation package in the last 24 hours, you may be able to cancel or change it free of charge. Your airline, hotel or car rental company may impose a fee if you made your booking a while ago.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.