Grand Isle Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ￥109,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Grand Isle

Find the best Grand Isle areas and neighborhoods for the activities you enjoy most. Learn more about Grand Isle
An aerial view of a town with a mix of commercial and residential buildings, a large parking lot, and a body of water.

Downtown Port St. Joe

While visiting Downtown Port St. Joe, you might make a stop by sights like Constitution Convention Museum State Park and Centennial Building.

Find hotels in Downtown Port St. Joe

Grand Isle Hotel Deals

Driftwood Inn

Driftwood Inn

2 out of 5
2105 U.S. 98 Mexico Beach FL
Fully refundableReserve now, pay when you stay
The price is ￥40,950 per night from Jul 26 to Jul 27
￥40,950
￥45,865 total
Jul 26 - Jul 27
includes taxes & fees
9.6/10 Exceptional! (64 reviews)
"Bathroom not near bedroom. Uncomfortable mattress. Uncomfortable sofa. Coffee maker did not work. Great beach view. Clean room. Easy parking."

Reviewed on Jun 25, 2026

Driftwood Inn
Comfort Suites

Comfort Suites

2.5 out of 5
264 N Tyndall Pkwy Panama City FL
Fully refundable
The price is ￥17,018 per night from Jul 19 to Jul 20
￥17,018
￥18,392 total
Jul 19 - Jul 20
includes taxes & fees
8.6/10 Excellent! (766 reviews)
"Great stayed. But the chairs in the dining room definitely need to be change or reupholster...."

Reviewed on Jun 22, 2026

Comfort Suites
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

2.5 out of 5
5627 E Highway 22 State Route Panama City FL
Fully refundable
The price is ￥21,031 per night from Jul 26 to Jul 27
￥21,031
￥22,729 total
Jul 26 - Jul 27
includes taxes & fees
8.6/10 Excellent! (487 reviews)
"Great breakfast buffet 😋"

Reviewed on Jun 26, 2026

Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
See all 2,279 properties in Grand Isle
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Grand Isle vacation package cost?
We make it simple to travel the world, with Grand Isle packages starting from just . You'll have the flexibility to bundle your preferred airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Grand Isle?
Booking a Grand Isle vacation package with Expedia is one of the easiest ways to save. We offer more than 550 air carriers and 1,000,000 properties throughout the world. With such a broad range to select from, you'll have no worries putting together your perfect adventure.
Where should I stay in Grand Isle?
If you're interested in visiting Mexico Beach, save yourself the stress of commuting and book a hotel nearby. It's one of the top attractions in this neighborhood.
What are the top hotels in Grand Isle?
Beautiful Fully Remodeled Home With Private Pool is one of Grand Isle's most sought-after properties. Secure a room here and you can snooze soundly knowing you're in capable hands.
How far in advance should I book my Grand Isle vacation?
It's always wise to book early. Air carriers generally advertise flight tickets around a year prior to departure, and this is an excellent opportunity to pick up some of the cheapest prices. Boss just told you to take some vacation time next month? No problem! Expedia are never short of fantastic bargains to send you off on the getaway of your dreams, at an affordable price.
What does an Expedia Grand Isle travel package include?
Flights, hotels and a reliable car for all your road trip adventures. Simply select your favorite bundle and gain access to great discounts. Once you've made your booking, add on some experiences and tours and watch your savings pile up. When it comes to crafting your Grand Isle vacation, you're in charge!
What should I know before booking a Grand Isle travel package?
A travel package can be tailored to your budget and is a great way to make your hard-earned dollars stretch further. How little or much you include is up to you. Rental cars, hotels and flights — mix and match whatever combination works with your plans.
Can I choose my airline with a Grand Isle Expedia vacation package?
With a vacation package, you're always in charge. Whether you're eager to fly to Grand Isle in economy or first class, simply select from the available airline options. Expedia has access to more than 550 airline partners across the world.
If I'm not able to travel, can I cancel my Grand Isle vacation package?
Because we understand life can throw you a few curveballs, the answer is yes. For further information, head to our Customer Service Portal. But generally speaking, if you've booked your Grand Isle vacation package in the last 24 hours, you may be able to cancel or change it free of charge. Your airline, hotel or car rental company may impose a fee if you made your booking a while ago.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.