Find hotels near Palmdale Regional Medical Center, Palmdale from ￥11,525

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 25 - Dec 26
Tomorrow
Dec 26 - Dec 27
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Palmdale Regional Medical Center hotels

Outdoor pool
DoubleTree by Hilton Palmdale, CA

DoubleTree by Hilton Palmdale, CA

DoubleTree by Hilton Palmdale, CA
4.0 star property
1.1 km from Palmdale Regional Medical Center
9.2 out of 10, Wonderful, (770)
"Great Service and staff."
United States
leticia
The price is ￥12,608
￥14,145 total
includes taxes & fees
Jan 4 - Jan 5, 2026
DoubleTree by Hilton Palmdale, CA
Lobby
Element Palmdale

Element Palmdale

Element Palmdale
3.0 star property
1.5 km from Palmdale Regional Medical Center
9.2 out of 10, Wonderful, (632)
"Staff was really friendly and accommodating! "
United States
Jose L
The price is ￥14,845
￥16,656 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Element Palmdale
View from property
Fairfield Inn & Suites by Marriott Palmdale West

Fairfield Inn & Suites by Marriott Palmdale West

Fairfield Inn & Suites by Marriott Palmdale West
2.5 star property
3 km from Palmdale Regional Medical Center
9.2 out of 10, Wonderful, (490)
"The hotel was very nice and clean I appreciate it the friendly staff. "
United States
Alejandro
The price is ￥16,218
￥18,195 total
includes taxes & fees
Dec 26 - Dec 27
Fairfield Inn & Suites by Marriott Palmdale West
Sports facility
Home2 Suites by Hilton Palmdale, CA

Home2 Suites by Hilton Palmdale, CA

Home2 Suites by Hilton Palmdale, CA
3.0 star property
0.8 km from Palmdale Regional Medical Center
9.0 out of 10, Wonderful, (391)
"The breakfast was great!"
United States
Wendy
The price is ￥12,502
￥14,026 total
includes taxes & fees
Jan 23 - Jan 24, 2026
Home2 Suites by Hilton Palmdale, CA
Reception
Embassy Suites Palmdale

Embassy Suites Palmdale

Embassy Suites Palmdale
3.5 star property
1.6 km from Palmdale Regional Medical Center
9.0 out of 10, Wonderful, (1115)
"Great location"
United States
Juan
The price is ￥16,717
￥18,755 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Embassy Suites Palmdale
Interior
Holiday Inn Palmdale-Lancaster by IHG

Holiday Inn Palmdale-Lancaster by IHG

Holiday Inn Palmdale-Lancaster by IHG
3.0 star property
0.8 km from Palmdale Regional Medical Center
8.8 out of 10, Excellent, (1001)
"Nice place to stay at !!"
United States
GAUDENCIO
The price is ￥14,502
￥16,271 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Palmdale-Lancaster by IHG
Property amenity
Residence Inn Palmdale Lancaster

Residence Inn Palmdale Lancaster

Residence Inn Palmdale Lancaster
3.0 star property
2.3 km from Palmdale Regional Medical Center
9.0 out of 10, Wonderful, (385)
"Great staff, clean rooms, restaurants are very close by !"
United States
Greg
The price is ￥18,806
￥21,063 total
includes taxes & fees
Dec 30 - Dec 31
Residence Inn Palmdale Lancaster
Property amenity
Courtyard Palmdale

Courtyard Palmdale

Courtyard Palmdale
3.0 star property
2.3 km from Palmdale Regional Medical Center
8.8 out of 10, Excellent, (932)
"The hotel was very clean and the staff was courteous. "
United States
Kenley
The price is ￥15,637
￥17,513 total
includes taxes & fees
Dec 26 - Dec 27
Courtyard Palmdale
Free continental breakfast
Best Western Plus John Jay Inn & Suites

Best Western Plus John Jay Inn & Suites

Best Western Plus John Jay Inn & Suites
2.5 star property
0.5 km from Palmdale Regional Medical Center
8.6 out of 10, Excellent, (1000)
"Always a great place to stay. "
United States
Julio
The price is ￥15,299
￥17,134 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Best Western Plus John Jay Inn & Suites
Restaurant
Hilton Garden Inn Palmdale

Hilton Garden Inn Palmdale

Hilton Garden Inn Palmdale
3.0 star property
2.3 km from Palmdale Regional Medical Center
8.8 out of 10, Excellent, (1000)
"Room was clean, staff was great!!"
United States
Cecilia
The price is ￥16,093
￥18,024 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton Garden Inn Palmdale
Exterior
Staybridge Suites Palmdale by IHG

Staybridge Suites Palmdale by IHG

Staybridge Suites Palmdale by IHG
3.0 star property
0.8 km from Palmdale Regional Medical Center
8.4 out of 10, Very Good, (586)
"The staff is very friendly the room was cozy and the breakfast was delicious "
United States
Julio
The price is ￥16,218
￥18,195 total
includes taxes & fees
Dec 26 - Dec 27
Staybridge Suites Palmdale by IHG
Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Hampton Inn & Suites Palmdale

Hampton Inn & Suites Palmdale

Hampton Inn & Suites Palmdale
2.5 star property
2 km from Palmdale Regional Medical Center
8.4 out of 10, Very Good, (1001)
"Clean room and courteous staff. Complimentary breakfast is always delicious. "
United States
Tamera
The price is ￥11,887
￥13,629 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn & Suites Palmdale
Laptop workspace, blackout drapes, bed sheets
Woodspring Suites Palmdale - Lancaster

Woodspring Suites Palmdale - Lancaster

Woodspring Suites Palmdale - Lancaster
2.5 star property
3 km from Palmdale Regional Medical Center
8.4 out of 10, Very Good, (176)
"This is one of the best places to stay away from home."
United States
Terenia
The price is ￥11,540
￥12,948 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Woodspring Suites Palmdale - Lancaster
Outdoor pool
Palms Inn & Suites

Palms Inn & Suites

Palms Inn & Suites
2.5 star property
0.8 km from Palmdale Regional Medical Center
6.8 out of 10, (1130)
"I really enjoyed my stay."
United States
Anna
Palms Inn & Suites
Lobby
Red Roof Inn Palmdale - Lancaster

Red Roof Inn Palmdale - Lancaster

Red Roof Inn Palmdale - Lancaster
2.0 star property
1.4 km from Palmdale Regional Medical Center
5.0 out of 10, (1000)
"Very nice at check in"
United States
Christina
The price is ￥10,290
￥11,525 total
includes taxes & fees
Dec 28 - Dec 29
Red Roof Inn Palmdale - Lancaster
Room, 1 King Bed | Desk, iron/ironing board, free WiFi, bed sheets
OYO Hotel Palmdale - Antelope Valley

OYO Hotel Palmdale - Antelope Valley

OYO Hotel Palmdale - Antelope Valley
2.0 star property
1.8 km from Palmdale Regional Medical Center
5.0 out of 10, (310)
"It was a good stay for a 24-hour period"
United States
Paul
The price is ￥9,905
￥12,185 total
includes taxes & fees
Jan 4 - Jan 5, 2026
OYO Hotel Palmdale - Antelope Valley
Property amenity
Fairfield Inn & Suites by Marriott Lancaster Palmdale

Fairfield Inn & Suites by Marriott Lancaster Palmdale

Fairfield Inn & Suites by Marriott Lancaster Palmdale
2.5 star property
11.1 km from Palmdale Regional Medical Center
9.4 out of 10, Exceptional, (671)
"Have stayed here for the 2nd time and it has been great! "
United States
Maria
The price is ￥16,686
￥18,471 total
includes taxes & fees
Dec 29 - Dec 30
Fairfield Inn & Suites by Marriott Lancaster Palmdale
Terrace/patio
TownePlace Suites by Marriott Lancaster, CA

TownePlace Suites by Marriott Lancaster, CA

TownePlace Suites by Marriott Lancaster, CA
3.0 star property
11.3 km from Palmdale Regional Medical Center
9.2 out of 10, Wonderful, (351)
"Wonderful hotel."
United States
david
The price is ￥19,508
￥21,594 total
includes taxes & fees
Dec 29 - Dec 30
TownePlace Suites by Marriott Lancaster, CA
Property amenity
Residence Inn by Marriott Lancaster Palmdale

Residence Inn by Marriott Lancaster Palmdale

Residence Inn by Marriott Lancaster Palmdale
3.0 star property
12.8 km from Palmdale Regional Medical Center
9.4 out of 10, Exceptional, (281)
"Clean room, great staff! "
United States
Janet
The price is ￥22,299
￥24,729 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Residence Inn by Marriott Lancaster Palmdale
Balcony King Room | Balcony view
Oxnard Inn Lancaster

Oxnard Inn Lancaster

Oxnard Inn Lancaster
3.0 star property
10.4 km from Palmdale Regional Medical Center
8.8 out of 10, Excellent, (1002)
"Always a nice and affordable stay."
United States
Amanda
The price is ￥14,604
￥16,137 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Oxnard Inn Lancaster
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Palmdale Regional Medical Center Hotel Reviews

Vagabond Inn Sylmar

Vagabond Inn Sylmar

10/10 Excellent
"Clean and quiet. Nice place for the price."
NANCY 1-night trip
Posted 1 day ago
Vagabond Inn Sylmar

Hotels near other Palmdale Regional Medical Center attractions

I <3 this place! I hope I can find w place like this back in WA!
Photo by Christine Buggs
Open Photo by Christine Buggs

Antelope Valley Mall

4.1/5 (133 reviews)
You can search for that perfect souvenir at Antelope Valley Mall during your trip to Palmdale. Check out the shops and top-notch restaurants in this family-friendly area.
See properties
Panoramic image looking east of Palmdale in Los Angeles county showing the California aqueduct in the foreground.

Lake Palmdale

4.1/5 (36 reviews)
Commune with nature and explore the great outdoors at Lake Palmdale during your travels in Palmdale. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
See properties

Frequently asked questions

What's the area like around Palmdale Regional Medical Center?
Palmdale Regional Medical Center is located in a welcoming area of Palmdale known for its array of dining options. If you're looking for a convenient place to stay, check out the 29 hotels and other accommodations you'll find within a mile.
What's the best place to stay near Palmdale Regional Medical Center?
Embassy Suites Palmdale is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a restaurant. It's located 1 mi (1.6 km) from Palmdale Regional Medical Center. Other good choices in the area include Triplodge of Santa Clarita and Hotel Burbank.
How many hotels will I find close to Palmdale Regional Medical Center?
Expedia has 29 hotels and other accommodations within a mile from Palmdale Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Palmdale Regional Medical Center, will I receive a refund?
Yes! The majority of hotel room reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to cancel it and be given a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best options available near Palmdale Regional Medical Center.
Where can I learn more about changing or cancelling my trip in the area near Palmdale Regional Medical Center?
To access more information about changing or cancelling your stay near Palmdale Regional Medical Center, go to https://www.expedia.com/service/.
What can I see and do near Palmdale Regional Medical Center?
You can enjoy live performances at Palmdale Playhouse and Palmdale Amphitheater. If you have some time to wander around the area, you might stop by Antelope Valley Country Club, Rancho Vista Golf Club, or Cinemark Antelope Valley Mall. If you want to see more of the surrounding area, you can plan a visit to Antelope Valley Mall and Palmdale City Hall.